2006
Interleukin 5 Plays an Essential Role in Elicitation of Contact Sensitivity through Dual Effects on Eosinophils and B-1 Cells
Itakura A, Kikuchi Y, Kouro T, Ikutani M, Takaki S, Askenase PW, Takatsu K. Interleukin 5 Plays an Essential Role in Elicitation of Contact Sensitivity through Dual Effects on Eosinophils and B-1 Cells. International Archives Of Allergy And Immunology 2006, 140: 8-16. PMID: 16772721, DOI: 10.1159/000092705.Peer-Reviewed Original ResearchConceptsElicitation of CSIgM-producing cellsContact sensitivityEosinophil peroxidase activityEosinophil infiltrationIL-5Antigen-specific immunoglobulin M antibodyCS-effector T cellsEnzyme-linked immunospot assayLocal tissueEffector T cellsRole of interleukinImmunoglobulin M antibodiesIL-5 receptorImmunized ILImmunospot assayContact sensitizationM antibodiesMononuclear cellsDeficient micePolymorphonuclear cellsT cellsImmune responseCell activationInterleukin-5
1996
Delayed-type hypersensitivity in mast cell-deficient mice: dependence on platelets for expression of contact sensitivity.
Geba GP, Ptak W, Anderson GM, Paliwal V, Ratzlaff RE, Levin J, Askenase PW. Delayed-type hypersensitivity in mast cell-deficient mice: dependence on platelets for expression of contact sensitivity. The Journal Of Immunology 1996, 157: 557-65. PMID: 8752902, DOI: 10.4049/jimmunol.157.2.557.Peer-Reviewed Original ResearchConceptsMast cell-deficient miceCell-deficient miceDelayed-type hypersensitivityContact sensitivityPlatelet depletionMast cellsCS responsesT cell-mediated immune responsesMast cell-deficient strainsDelayed-type hypersensitivity responseT cell-mediated responsesCell-mediated immune responsesTissue levelsCutaneous sensitivity responsesVasoactive amine serotoninCell-mediated responsesLocal mast cellsMast cell numbersNormal mast cell numbersHypersensitivity responseCutaneous responseImmunologic evidenceBeige miceImmune responseAmine serotonin