2006
Interleukin 5 Plays an Essential Role in Elicitation of Contact Sensitivity through Dual Effects on Eosinophils and B-1 Cells
Itakura A, Kikuchi Y, Kouro T, Ikutani M, Takaki S, Askenase PW, Takatsu K. Interleukin 5 Plays an Essential Role in Elicitation of Contact Sensitivity through Dual Effects on Eosinophils and B-1 Cells. International Archives Of Allergy And Immunology 2006, 140: 8-16. PMID: 16772721, DOI: 10.1159/000092705.Peer-Reviewed Original ResearchConceptsElicitation of CSIgM-producing cellsContact sensitivityEosinophil peroxidase activityEosinophil infiltrationIL-5Antigen-specific immunoglobulin M antibodyCS-effector T cellsEnzyme-linked immunospot assayLocal tissueEffector T cellsRole of interleukinImmunoglobulin M antibodiesIL-5 receptorImmunized ILImmunospot assayContact sensitizationM antibodiesMononuclear cellsDeficient micePolymorphonuclear cellsT cellsImmune responseCell activationInterleukin-5
1999
C-C chemokines in allergen-induced late-phase cutaneous responses in atopic subjects: association of eotaxin with early 6-hour eosinophils, and of eotaxin-2 and monocyte chemoattractant protein-4 with the later 24-hour tissue eosinophilia, and relationship to basophils and other C-C chemokines (monocyte chemoattractant protein-3 and RANTES).
Ying S, Robinson D, Meng Q, Barata L, McEuen A, Buckley M, Walls A, Askenase P, Kay A. C-C chemokines in allergen-induced late-phase cutaneous responses in atopic subjects: association of eotaxin with early 6-hour eosinophils, and of eotaxin-2 and monocyte chemoattractant protein-4 with the later 24-hour tissue eosinophilia, and relationship to basophils and other C-C chemokines (monocyte chemoattractant protein-3 and RANTES). The Journal Of Immunology 1999, 163: 3976-84. PMID: 10491000, DOI: 10.4049/jimmunol.163.7.3976.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAllergensBasophilsCell MovementChemokine CCL11Chemokine CCL24Chemokine CCL5Chemokine CCL7Chemokines, CCCytokinesDermatitis, AtopicEosinophiliaEosinophilsHumansImmunophenotypingMiddle AgedMonocyte Chemoattractant ProteinsReceptors, CCR3Receptors, ChemokineRNA, MessengerTime FactorsConceptsMonocyte chemoattractant protein-3C-C chemokinesEotaxin-2MCP-4T cellsAtopic subjectsLate-phase cutaneous responseCD4+ T cellsEotaxin receptor CCR3Human atopic subjectsMonocyte chemoattractant protein-4CD3+ cellsCD68+ macrophagesEG2+ eosinophilsExpression of eotaxinCCR3+ cellsMCP-4 mRNAElastase+ neutrophilsLate eosinophiliaAllergic tissue reactionsEotaxin proteinCD3+Allergen-inducedRelationship of expressionEotaxin mRNA