2021
Trends in Hepatocellular Carcinoma Incidence and Risk Among Persons With HIV in the US and Canada, 1996-2015
Sun J, Althoff KN, Jing Y, Horberg MA, Buchacz K, Gill MJ, Justice AC, Rabkin CS, Goedert JJ, Sigel K, Cachay E, Park L, Lim JK, Kim HN, Re V, Moore R, Sterling T, Peters MG, Achenbach CJ, Silverberg M, Thorne JE, Mayor AM, Crane HM, Kitahata MM, Klein M, Kirk GD. Trends in Hepatocellular Carcinoma Incidence and Risk Among Persons With HIV in the US and Canada, 1996-2015. JAMA Network Open 2021, 4: e2037512. PMID: 33595662, PMCID: PMC7890526, DOI: 10.1001/jamanetworkopen.2020.37512.Peer-Reviewed Original ResearchConceptsHCC incidence ratesHigher HCC riskHepatitis C virusHepatitis B virusModern cART eraCD4 cell countIncidence rateCART eraHCC riskHepatocellular carcinomaCohort studyTriple infectionNorth American AIDS Cohort CollaborationCell countAvailable CD4 cell countHigher HIV RNA levelsLow CD4 cell countsCombination antiretroviral therapy eraDiagnosis of HCCAnti-HCV seropositivityAntiretroviral therapy eraHBV-HCV coinfectionRecent HIV RNAHIV RNA levelsHBV e antigen
2020
Brief Report: Accuracy of FIB-4 for Cirrhosis in People Living With HIV and Hepatocellular Carcinoma.
Torgersen J, Kallan MJ, Carbonari DM, Park LS, Mehta RL, D'Addeo K, Tate JP, Lim JK, Goetz MB, Rodriguez-Barradas MC, Bräu N, Brown ST, Taddei TH, Justice AC, Lo Re V. Brief Report: Accuracy of FIB-4 for Cirrhosis in People Living With HIV and Hepatocellular Carcinoma. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2020, 85: 530-534. PMID: 33185999, PMCID: PMC8353543, DOI: 10.1097/qai.0000000000002510.Peer-Reviewed Original ResearchConceptsSetting of HCCFIB-4Receiver-operating characteristic curveHepatocellular carcinomaHCC diagnosisPredictive valueVeterans Aging Cohort StudyEvidence of cirrhosisSetting of HIVAbsence of cirrhosisFIB-4 scoreFibrosis-4 indexIncident hepatocellular carcinomaMedical record reviewPrevalence of cirrhosisAging Cohort StudyCross-sectional studyCharacteristic curveNegative predictive valuePositive predictive valueCirrhosis statusCohort studyMechanisms of carcinogenesisRecord reviewPlatelet countDifferences in Pathology, Staging, and Treatment between HIV+ and Uninfected Patients with Microscopically Confirmed Hepatocellular Carcinoma
Torgersen J, Taddei TH, Park LS, Carbonari DM, Kallan MJ, Richards K, Zhang X, Jhala D, Bräu N, Homer R, D'Addeo K, Mehta R, Skanderson M, Kidwai-Khan F, Justice AC, Re V. Differences in Pathology, Staging, and Treatment between HIV+ and Uninfected Patients with Microscopically Confirmed Hepatocellular Carcinoma. Cancer Epidemiology Biomarkers & Prevention 2020, 29: 71-78. PMID: 31575557, PMCID: PMC6980754, DOI: 10.1158/1055-9965.epi-19-0503.Peer-Reviewed Original ResearchMeSH KeywordsAblation TechniquesCarcinoma, HepatocellularFemaleHepatectomyHIV InfectionsHospitals, VeteransHumansImmunologic SurveillanceKaplan-Meier EstimateLiverLiver CirrhosisLiver NeoplasmsLiver TransplantationMaleMiddle AgedNeoplasm StagingRetrospective StudiesRisk FactorsTreatment OutcomeUnited StatesConceptsBarcelona Clinic Liver Cancer stageHIV statusHepatocellular carcinomaUninfected patientsHIV infectionTumor characteristicsUninfected personsPathology reportsVeterans Aging Cohort StudyLiver tissue samplingCohort of HIVMultivariable Cox regressionAdvanced hepatic fibrosisAging Cohort StudyLiver Cancer stageRisk of deathBackground hepatic parenchymaCohort studyHazard ratioLymphovascular invasionBCLC stageImproved survivalCox regressionHistologic featuresHepatic fibrosis
2019
HIV RNA, CD4+ Percentage, and Risk of Hepatocellular Carcinoma by Cirrhosis Status
Torgersen J, Kallan MJ, Carbonari DM, Park LS, Mehta RL, D’Addeo K, Tate JP, Lim JK, Goetz MB, Rodriguez-Barradas MC, Gibert CL, Bräu N, Brown ST, Roy JA, Taddei TH, Justice AC, Re V. HIV RNA, CD4+ Percentage, and Risk of Hepatocellular Carcinoma by Cirrhosis Status. Journal Of The National Cancer Institute 2019, 112: 747-755. PMID: 31687755, PMCID: PMC7357318, DOI: 10.1093/jnci/djz214.Peer-Reviewed Original ResearchConceptsRisk of HCCHigher HIV RNAHCC risk factorsHIV RNAHIV viremiaHepatocellular carcinomaBaseline cirrhosisCirrhosis statusCohort studyRisk factorsCell percentageVeterans Aging Cohort StudyDevelopment of HCCCurrent HIV RNADetectable HIV viremiaHepatitis C coinfectionAging Cohort StudyDiagnosis of cirrhosisLonger durationDetectable HIVLow CD4C coinfectionCurrent CD4Hazard ratioCancer Registry
2014
Hepatic decompensation in antiretroviral-treated patients co-infected with HIV and hepatitis C virus compared with hepatitis C virus-monoinfected patients: a cohort study.
Lo Re V, Kallan MJ, Tate JP, Localio AR, Lim JK, Goetz MB, Klein MB, Rimland D, Rodriguez-Barradas MC, Butt AA, Gibert CL, Brown ST, Park L, Dubrow R, Reddy KR, Kostman JR, Strom BL, Justice AC. Hepatic decompensation in antiretroviral-treated patients co-infected with HIV and hepatitis C virus compared with hepatitis C virus-monoinfected patients: a cohort study. Annals Of Internal Medicine 2014, 160: 369-79. PMID: 24723077, PMCID: PMC4254786, DOI: 10.7326/m13-1829.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnti-Retroviral AgentsAscitesBacterial InfectionsCarcinoma, HepatocellularCoinfectionEsophageal and Gastric VaricesFemaleGastrointestinal HemorrhageHepatitis C, ChronicHIVHIV InfectionsHumansIncidenceLiver NeoplasmsMaleMedication AdherenceMiddle AgedPeritonitisRetrospective StudiesRNA, ViralTreatment OutcomeViral LoadConceptsCo-infected patientsHepatitis C virusHepatic decompensationAntiretroviral-treated patientsCohort studyNonblack raceC virusHepatitis C virus-monoinfected patientsChronic hepatitis C virusHigh rateAntiretroviral therapy eraDetectable HCV RNAIncident hepatic decompensationBaseline hemoglobin levelRetrospective cohort studySpontaneous bacterial peritonitisAdvanced hepatic fibrosisAdvanced liver fibrosisVeterans Health AdministrationDiagnosis of ascitesRate of decompensationTherapy eraHIV RNAVariceal hemorrhageHCV RNA
2011
FIB-4 Index Is Associated with Hepatocellular Carcinoma Risk in HIV-Infected Patients
Park LS, Tate JP, Justice AC, Re V, Lim JK, Bräu N, Brown ST, Butt AA, Gibert C, Goetz MB, Rimland D, Rodriguez-Barradas MC, Dubrow R. FIB-4 Index Is Associated with Hepatocellular Carcinoma Risk in HIV-Infected Patients. Cancer Epidemiology Biomarkers & Prevention 2011, 20: 2512-2517. PMID: 22028407, PMCID: PMC3237927, DOI: 10.1158/1055-9965.epi-11-0582.Peer-Reviewed Original ResearchConceptsHigh FIB-4C virus infectionFIB-4Hepatocellular carcinomaVirus infectionRisk factorsHigh riskVeterans Affairs Central Cancer RegistryAlcohol abuse/dependencyHIV-1 RNA levelsHepatitis B virus infectionHepatitis C virus infectionVeterans Aging Cohort StudyDevelopment of HCCLow FIB-4Multivariate-adjusted HRNoninvasive laboratory testsAntiretroviral therapy useFIB-4 indexB virus infectionIndependent risk factorHCC risk factorsAging Cohort StudyIncident HCC casesCentral Cancer Registry
2006
Hepatocellular Carcinoma and Non-Hodgkin's Lymphoma: The Roles of HIV, Hepatitis C Infection, and Alcohol Abuse
McGinnis KA, Fultz SL, Skanderson M, Conigliaro J, Bryant K, Justice AC. Hepatocellular Carcinoma and Non-Hodgkin's Lymphoma: The Roles of HIV, Hepatitis C Infection, and Alcohol Abuse. Journal Of Clinical Oncology 2006, 24: 5005-5009. PMID: 17075119, DOI: 10.1200/jco.2006.05.7984.Peer-Reviewed Original ResearchConceptsAlcohol abuse/dependenceHIV-negative veteransAbuse/dependenceHIV-positive veteransIncident rate ratiosHepatocellular carcinomaGreater riskVeterans Affairs Healthcare SystemFirst HIV diagnosisHepatitis C infectionPresence of HCVRole of HIVNinth Revision codesNon-Hodgkin lymphomaRelationship of HIVHeavy alcohol useHigher relative incidencePoisson regression modelsC infectionHCV infectionHepatitis CHIV diagnosisHIV statusHodgkin's lymphomaRevision codes
2003
Testing, Referral, and Treatment Patterns for Hepatitis C Virus Coinfection in a Cohort of Veterans with Human Immunodeficiency Virus Infection
Fultz SL, Justice AC, Butt AA, Rabeneck L, Weissman S, Rodriguez-Barradas M, Team V. Testing, Referral, and Treatment Patterns for Hepatitis C Virus Coinfection in a Cohort of Veterans with Human Immunodeficiency Virus Infection. Clinical Infectious Diseases 2003, 36: 1039-1046. PMID: 12684917, DOI: 10.1086/374049.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAlcohol DrinkingAntiviral AgentsCarcinoma, HepatocellularFemaleHepacivirusHepatitis CHIVHIV InfectionsHumansMaleMiddle AgedConceptsAlcohol consumptionHepatitis CHuman immunodeficiency virus-positive patientsHepatitis C virus coinfectionHuman immunodeficiency virus (HIV) infectionImmunodeficiency virus-positive patientsC virus coinfectionUnderwent liver biopsyHepatitis C therapyImmunodeficiency virus infectionVirus-positive patientsHepatitis C treatmentTreatment of patientsCohort of veteransVeterans Affairs electronic medical recordsHepatitis C virusCurrent alcohol consumptionHealth care providersElectronic medical recordsC therapyCohort studyLiver biopsyTreatment patternsVirus coinfectionPsychiatric comorbidity