2024
Immune modulation in transplant medicine: a comprehensive review of cell therapy applications and future directions
Knoedler L, Dean J, Diatta F, Thompson N, Knoedler S, Rhys R, Sherwani K, Ettl T, Mayer S, Falkner F, Kilian K, Panayi A, Iske J, Safi A, Tullius S, Haykal S, Pomahac B, Kauke-Navarro M. Immune modulation in transplant medicine: a comprehensive review of cell therapy applications and future directions. Frontiers In Immunology 2024, 15: 1372862. PMID: 38650942, PMCID: PMC11033354, DOI: 10.3389/fimmu.2024.1372862.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell- and Tissue-Based TherapyGraft RejectionHumansImmunomodulationOrgan TransplantationConceptsRegulatory myeloid cellsSolid organ transplantationVascularized composite allotransplantationMesenchymal stromal cellsT cellsTransplant patientsCellular therapyChimeric antigen receptor T cellsTransplant surgerySide effectsIncreased risk of malignancyProgression to chronic rejectionAcute rejection ratesPerioperative treatment strategiesRegulatory T cellsPromote immune toleranceRisk of malignancySystemic side effectsRelated side effectsCell typesImprove transplant survivalCAR-TCell therapy applicationsImmunosuppressive regimensChronic rejection
2023
Novel Strategies in Transplantation: Genetic Engineering and Vascularized Composite Allotransplantation
Kauke-Navarro M, Noel O, Knoedler L, Knoedler S, Panayi A, Stoegner V, Huelsboemer L, Pomahac B. Novel Strategies in Transplantation: Genetic Engineering and Vascularized Composite Allotransplantation. Journal Of Surgical Research 2023, 291: 176-186. PMID: 37429217, DOI: 10.1016/j.jss.2023.04.028.Peer-Reviewed Original ResearchMeSH KeywordsGenetic EngineeringGraft RejectionHumansImmunosuppressive AgentsOrgan TransplantationTransplantation, HomologousVascularized Composite AllotransplantationConceptsImmunosuppressive regimensAllograft rejectionComposite allotransplantationDonor-derived immune cellsDonor-derived T lymphocytesRecipient-derived T cellsPotent immunosuppressive regimensToxic immunosuppressive regimensSolid organ transplantationAntigen-presenting cellsSystemic side effectsVascularized Composite AllotransplantationCD40 knockoutChronic rejectionRejection episodesSystemic immunosuppressionMost patientsImmunomodulatory strategiesTolerance inductionImmune cellsOrgan transplantationT cellsT lymphocytesSide effectsClinical success
2018
Innovations in reconstructive microsurgery: Reconstructive transplantation
Kollar B, Tasigiorgos S, Dorante M, Carty M, Talbot S, Pomahac B. Innovations in reconstructive microsurgery: Reconstructive transplantation. Journal Of Surgical Oncology 2018, 118: 800-806. PMID: 30098294, DOI: 10.1002/jso.25147.Peer-Reviewed Original ResearchMeSH KeywordsForecastingGraft RejectionGraft SurvivalHumansImmunosuppressive AgentsMicrosurgeryOrgan TransplantationConceptsReconstructive transplantationViable reconstructive optionPediatric transplantsUpper extremityLower extremitiesAbdominal wallReconstructive optionsAdditional proceduresReconstructive microsurgeryTransplantationFace transplantTransplantPresent review articleExtremitiesReview articlePatientsUterusNeck
2017
The promise of organ and tissue preservation to transform medicine
Giwa S, Lewis J, Alvarez L, Langer R, Roth A, Church G, Markmann J, Sachs D, Chandraker A, Wertheim J, Rothblatt M, Boyden E, Eidbo E, Lee W, Pomahac B, Brandacher G, Weinstock D, Elliott G, Nelson D, Acker J, Uygun K, Schmalz B, Weegman B, Tocchio A, Fahy G, Storey K, Rubinsky B, Bischof J, Elliott J, Woodruff T, Morris G, Demirci U, Brockbank K, Woods E, Ben R, Baust J, Gao D, Fuller B, Rabin Y, Kravitz D, Taylor M, Toner M. The promise of organ and tissue preservation to transform medicine. Nature Biotechnology 2017, 35: 530-542. PMID: 28591112, PMCID: PMC5724041, DOI: 10.1038/nbt.3889.Peer-Reviewed Original ResearchOutcomes of Solid Organ Transplants After Simultaneous Solid Organ and Vascularized Composite Allograft Procurements
Aycart M, Alhefzi M, Sharma G, Krezdorn N, Bueno E, Talbot S, Carty M, Tullius S, Pomahac B. Outcomes of Solid Organ Transplants After Simultaneous Solid Organ and Vascularized Composite Allograft Procurements. Transplantation 2017, 101: 1381-1386. PMID: 27140518, PMCID: PMC6347371, DOI: 10.1097/tp.0000000000001262.Peer-Reviewed Original ResearchMeSH KeywordsAdultComposite Tissue AllograftsFacial TransplantationFemaleGraft SurvivalHumansMaleMiddle AgedOperative TimeOrgan TransplantationPostoperative ComplicationsRegistriesRetrospective StudiesRisk AssessmentRisk FactorsTime FactorsTissue and Organ HarvestingTissue DonorsTreatment OutcomeUnited StatesYoung AdultConceptsGraft survival ratesSolid organsSurvival rateLiver recipientsTransplant recipientsAllograft procurementSolid organ allograftsSolid organ transplantsBrain-dead donorsLong-term outcomesShort-term resultsHeart recipientsIntraoperative parametersDonor surgeryOperative durationOrgan allograftsPostoperative outcomesScientific RegistryTransplantation outcomesPopulation of subjectsCase reportOperative characteristicsUnknown causeNationwide analysisOrgan transplants