2024
To Face Transplant or Not Face Transplant? Evaluating the Limitations of ChatGPT's Consideration of Ethical Themes
Boroumand S, Gu E, Huelsboemer L, Stögner V, Parikh N, Kauke-Navarro M, Pomahac B. To Face Transplant or Not Face Transplant? Evaluating the Limitations of ChatGPT's Consideration of Ethical Themes. Annals Of Plastic Surgery 2024, 93: 527-529. PMID: 39331750, DOI: 10.1097/sap.0000000000004072.Peer-Reviewed Original ResearchFrom standard therapies to monoclonal antibodies and immune checkpoint inhibitors – an update for reconstructive surgeons on common oncological cases
Knoedler L, Huelsboemer L, Hollmann K, Alfertshofer M, Herfeld K, Hosseini H, Boroumand S, Stoegner V, Safi A, Perl M, Knoedler S, Pomahac B, Kauke-Navarro M. From standard therapies to monoclonal antibodies and immune checkpoint inhibitors – an update for reconstructive surgeons on common oncological cases. Frontiers In Immunology 2024, 15: 1276306. PMID: 38715609, PMCID: PMC11074450, DOI: 10.3389/fimmu.2024.1276306.Peer-Reviewed Original ResearchConceptsImmune checkpoint inhibitorsHead and neck cancerBreast cancerMonoclonal antibodiesCheckpoint inhibitorsSkin cancerReconstructive surgeryNon-surgical treatment strategiesProlonged progression-free survivalSuboptimal treatment plansProgression-free survivalNon-surgical therapySurgical tumor resectionImpaired patient outcomeStandardized treatment algorithmSurgical therapy planningAnti-cancer strategyUnresectable tumorsConventional chemotherapyRemission rateTumor resectionCurative therapyTargeted therapyNeck cancerOncology casesCellular therapeutics and immunotherapies in wound healing – on the pulse of time?
Huelsboemer L, Knoedler L, Kochen A, Yu C, Hosseini H, Hollmann K, Choi A, Stögner V, Knoedler S, Hsia H, Pomahac B, Kauke-Navarro M. Cellular therapeutics and immunotherapies in wound healing – on the pulse of time? Military Medical Research 2024, 11: 23. PMID: 38637905, PMCID: PMC11025282, DOI: 10.1186/s40779-024-00528-5.Peer-Reviewed Original ResearchConceptsStandard of careChronic wound healing disordersLocal wound irrigationWound healingChronic inflammatory microenvironmentFree flap techniqueWound healing disordersChronic woundsGenetic risk profilesPhysiological wound healingAdequate blood supplySurgical debridementFlap techniqueCellular therapyCurrent therapiesHealing disordersInflammatory microenvironmentWound irrigationNon-healing woundsCellular therapeuticsGeneral anesthesiaFormation of biofilmsWound debridementSkin graftsImmunotherapyImmune modulation in transplant medicine: a comprehensive review of cell therapy applications and future directions
Knoedler L, Dean J, Diatta F, Thompson N, Knoedler S, Rhys R, Sherwani K, Ettl T, Mayer S, Falkner F, Kilian K, Panayi A, Iske J, Safi A, Tullius S, Haykal S, Pomahac B, Kauke-Navarro M. Immune modulation in transplant medicine: a comprehensive review of cell therapy applications and future directions. Frontiers In Immunology 2024, 15: 1372862. PMID: 38650942, PMCID: PMC11033354, DOI: 10.3389/fimmu.2024.1372862.Peer-Reviewed Original ResearchConceptsRegulatory myeloid cellsSolid organ transplantationVascularized composite allotransplantationMesenchymal stromal cellsT cellsTransplant patientsCellular therapyChimeric antigen receptor T cellsTransplant surgerySide effectsIncreased risk of malignancyProgression to chronic rejectionAcute rejection ratesPerioperative treatment strategiesRegulatory T cellsPromote immune toleranceRisk of malignancySystemic side effectsRelated side effectsCell typesImprove transplant survivalCAR-TCell therapy applicationsImmunosuppressive regimensChronic rejection
2023
Surgical management of breast fat necrosis: Multi-institutional data analysis of early outcomes and risk factors for complications
Knoedler S, Knoedler L, Patel H, Diatta F, Camacho J, Sofo G, Perozzo F, Evans B, Mookerjee V, Ayyala H, Pomahac B, Kauke-Navarro M. Surgical management of breast fat necrosis: Multi-institutional data analysis of early outcomes and risk factors for complications. Journal Of Plastic Reconstructive & Aesthetic Surgery 2023, 88: 292-295. PMID: 38029475, DOI: 10.1016/j.bjps.2023.11.015.Peer-Reviewed Original ResearchConceptsBreast fat necrosisChronic heart failureRisk factorsAdverse eventsHeart failureFemale patientsSurgical managementFat necrosisNational Surgical Quality Improvement ProgramSurgical Quality Improvement ProgramHigher wound classPostoperative adverse eventsNon-cancerous conditionsOutcomes of interestQuality Improvement ProgramMajority of casesPerioperative algorithmWound classComplication occurrenceComplication ratePostoperative outcomesSurgical complicationsMedical complicationsSurgical treatmentMultivariable analysisRegulatory T cells in skin regeneration and wound healing
Knoedler S, Knoedler L, Kauke-Navarro M, Rinkevich Y, Hundeshagen G, Harhaus L, Kneser U, Pomahac B, Orgill D, Panayi A. Regulatory T cells in skin regeneration and wound healing. Military Medical Research 2023, 10: 49. PMID: 37867188, PMCID: PMC10591349, DOI: 10.1186/s40779-023-00484-6.Peer-Reviewed Original ResearchConceptsRegulatory T cellsT cellsRole of TregsIntegumentary systemNew treatment modalitiesTissue-resident cellsSubsequent wound healing processCutaneous wound healingExcessive inflammationImmune homeostasisTreatment modalitiesImmune cellsSkin adnexaWound healing processImmune responseTregsHealing processWound repairWound healingHealingEpidermal integrityCellsCollateral damageAdnexaInflammationVascularized Composite Allograft Versus Prosthetic for Reconstruction After Facial and Hand Trauma
Noel O, Dumbrava M, Daoud D, Kammien A, Kauke-Navarro M, Pomahac B, Colen D. Vascularized Composite Allograft Versus Prosthetic for Reconstruction After Facial and Hand Trauma. Annals Of Plastic Surgery 2023, 92: 100-105. PMID: 37962243, DOI: 10.1097/sap.0000000000003731.Peer-Reviewed Original ResearchConceptsHand traumaHand/upper extremityLong-term outcomesUpper extremity traumaDifferent reconstructive optionsUse of prosthesesExtremity traumaBenefit profileUpper extremityReconstructive optionsComposite allotransplantationFace traumaHand reconstructionTraumaClinical realityPrimary optionProsthesisPatientsVCA18 years of face transplantation: Adverse outcomes and challenges
Longo B, Pomahac B, Giacalone M, Cardillo M, Cervelli V. 18 years of face transplantation: Adverse outcomes and challenges. Journal Of Plastic Reconstructive & Aesthetic Surgery 2023, 87: 187-199. PMID: 37879143, DOI: 10.1016/j.bjps.2023.09.043.Peer-Reviewed Original ResearchConceptsAllograft lossAdverse outcomesFace transplantationMedian timeStandard of careGoogle Scholar databasesFace transplant teamHeterogeneity of casesAllograft removalChronic rejectionInfectious complicationsIrreversible rejectionMajor complicationsTransplant centersTransplant casesTransplant teamPatient deathPRISMA guidelinesComplicationsSystematic reviewTransplantationScholar databasesSingle center approachSignificant riskPeer-reviewed literatureInternational consensus recommendations on face transplantation: A 2-step Delphi study
Longo B, Alberti F, Pomahac B, Pribaz J, Meningaud J, Lengelé B, Özkan Ö, Özkan Ö, Barret J, Lassus P, Blondeel P, Roche N, Gurunian R, Infante-Cossio P, Lindford A, Brandacher G, Giovanoli P, Plock J, Gorantla V, Herrington E, Saleh D, Natalwala I, Cardillo M, Jowsey-Gregoire S, La Padula S, Manas D, Benedict J, Nuccitelli G, Bosc R, Morello R, Farías-Yapur A, Giacalone M, Hall S, D’Orsi G, Cervelli V. International consensus recommendations on face transplantation: A 2-step Delphi study. American Journal Of Transplantation 2023, 24: 104-114. PMID: 37666457, PMCID: PMC10881406, DOI: 10.1016/j.ajt.2023.08.023.Peer-Reviewed Original ResearchFibroblasts – the cellular choreographers of wound healing
Knoedler S, Broichhausen S, Guo R, Dai R, Knoedler L, Kauke-Navarro M, Diatta F, Pomahac B, Machens H, Jiang D, Rinkevich Y. Fibroblasts – the cellular choreographers of wound healing. Frontiers In Immunology 2023, 14: 1233800. PMID: 37646029, PMCID: PMC10461395, DOI: 10.3389/fimmu.2023.1233800.Peer-Reviewed Original ResearchConceptsFibroblast diversityInnate immune cellsNovel treatment modalitiesWound healing functionsFascial connective tissueRole of fibroblastsTreatment modalitiesImmune cellsWound repairScar tissueDiversityFibroblastsConnective tissueHealing processWound healingComprehensive understandingMachineryTissueHealing functionCascadeNovel Strategies in Transplantation: Genetic Engineering and Vascularized Composite Allotransplantation
Kauke-Navarro M, Noel O, Knoedler L, Knoedler S, Panayi A, Stoegner V, Huelsboemer L, Pomahac B. Novel Strategies in Transplantation: Genetic Engineering and Vascularized Composite Allotransplantation. Journal Of Surgical Research 2023, 291: 176-186. PMID: 37429217, DOI: 10.1016/j.jss.2023.04.028.Peer-Reviewed Original ResearchConceptsImmunosuppressive regimensAllograft rejectionComposite allotransplantationDonor-derived immune cellsDonor-derived T lymphocytesRecipient-derived T cellsPotent immunosuppressive regimensToxic immunosuppressive regimensSolid organ transplantationAntigen-presenting cellsSystemic side effectsVascularized Composite AllotransplantationCD40 knockoutChronic rejectionRejection episodesSystemic immunosuppressionMost patientsImmunomodulatory strategiesTolerance inductionImmune cellsOrgan transplantationT cellsT lymphocytesSide effectsClinical successRates of National Institutes of Health Funding for Surgeon-Scientists, 1995-2020
Nguyen M, Gonzalez L, Newman A, Cannon A, Zarebski S, Chaudhry S, Pomahac B, Boatright D, Dardik A. Rates of National Institutes of Health Funding for Surgeon-Scientists, 1995-2020. JAMA Surgery 2023, 158: 756-764. PMID: 37195709, PMCID: PMC10193263, DOI: 10.1001/jamasurg.2023.1571.Peer-Reviewed Original ResearchConceptsHealth fundingNational InstituteNIH fundingCross-sectional studyDepartment of SurgeryGlobal disease burdenNumber of NIHNIH RePORTER databaseDisease burdenSurgical diseaseSurgical departmentPatient careResearch project grantsClinical settingSurgical subspecialtiesPhD scientistsSurgeryNIH grantsSubstantial disparitiesBoard certificationNIH investigatorsNIHClinical demandInvestigatorsProject grantsThe surgical patient of yesterday, today, and tomorrow—a time-trend analysis based on a cohort of 8.7 million surgical patients
Knoedler S, Matar D, Friedrich S, Knoedler L, Haug V, Hundeshagen G, Kauke-Navarro M, Kneser U, Pomahac B, Orgill D, Panayi A. The surgical patient of yesterday, today, and tomorrow—a time-trend analysis based on a cohort of 8.7 million surgical patients. International Journal Of Surgery 2023, 109: 2631-2640. PMID: 37788019, PMCID: PMC10498871, DOI: 10.1097/js9.0000000000000511.Peer-Reviewed Original ResearchConceptsSurgical patientsMedian ageMedian BMISurgeons National Surgical Quality Improvement Program databaseNational Surgical Quality Improvement Program databaseQuality Improvement Program databaseACS-NSQIP databaseImprovement Program databaseObesity class IProportion of patientsCohort of patientsPrevalence of diabetesType 2 diabetesGlobal healthcare deliveryFuture surgical careField of surgeryTime trend analysisPatient ageSurgical cohortDiabetes prevalenceProgram databaseSurgical careAmerican CollegeGeneral populationPatientsCellular activation pathways and interaction networks in vascularized composite allotransplantation
Knoedler L, Knoedler S, Panayi A, Lee C, Sadigh S, Huelsboemer L, Stoegner V, Schroeter A, Kern B, Mookerjee V, Lian C, Tullius S, Murphy G, Pomahac B, Kauke-Navarro M. Cellular activation pathways and interaction networks in vascularized composite allotransplantation. Frontiers In Immunology 2023, 14: 1179355. PMID: 37266446, PMCID: PMC10230044, DOI: 10.3389/fimmu.2023.1179355.Peer-Reviewed Original ResearchConceptsVascularized Composite AllotransplantationComposite allotransplantationRecipient-derived lymphocytesTreatment of patientsCellular activation pathwaysMultidrug immunosuppressionVCA graftsVCA patientsVCA rejectionGraft rejectionDevastating injuriesClinical managementNovel therapiesReconstructive surgeryLimb lossRejection responseFacial disfigurementAllotransplantationPatientsGraftActivation pathwayTissue cellsDifferent cell typesTissue typesCell typesCorrelation between facial vascularized composite allotransplantation rejection and laboratory markers: Insights from a retrospective study of eight patients
Kauke-Navarro M, Knoedler S, Panayi A, Knoedler L, Haller B, Parikh N, Huelsboemer L, Stoegner V, Kiefer J, Eisenhardt S, Azzi J, Pomahac B. Correlation between facial vascularized composite allotransplantation rejection and laboratory markers: Insights from a retrospective study of eight patients. Journal Of Plastic Reconstructive & Aesthetic Surgery 2023, 83: 155-164. PMID: 37276734, DOI: 10.1016/j.bjps.2023.04.050.Peer-Reviewed Original ResearchGender Disparity in National Institutes of Health Funding Among Surgeon-Scientists From 1995 to 2020
Nguyen M, Gonzalez L, Chaudhry S, Ahuja N, Pomahac B, Newman A, Cannon A, Zarebski S, Dardik A, Boatright D. Gender Disparity in National Institutes of Health Funding Among Surgeon-Scientists From 1995 to 2020. JAMA Network Open 2023, 6: e233630. PMID: 36939702, PMCID: PMC10028489, DOI: 10.1001/jamanetworkopen.2023.3630.Peer-Reviewed Original ResearchConceptsCross-sectional studyNIH fundingNational InstitutePatient-centered researchNIH RePORTER databaseWarrants further investigationPrincipal investigatorSurgical diseaseGlobal burdenMAIN OUTCOMEResearch project grantsSurgeonsWomenHealth fundingAcademic surgeonsMenNIH grantsDiseaseFurther investigationLow-dose interleukin-2 promotes immune regulation in face transplantation: A pilot study
Murakami N, Borges T, Win T, Abarzua P, Tasigiorgos S, Kollar B, Barrera V, Ho Sui S, Teague J, Bueno E, Clark R, Lian C, Murphy G, Pomahac B, Riella L. Low-dose interleukin-2 promotes immune regulation in face transplantation: A pilot study. American Journal Of Transplantation 2023, 23: 549-558. PMID: 36740193, PMCID: PMC10318113, DOI: 10.1016/j.ajt.2023.01.016.Peer-Reviewed Original ResearchConceptsLow-dose IL-2 therapyIL-2 therapySkin allograftsFace transplant recipientsTransplant recipientsIL-2Immune regulationLow-dose interleukin-2 (IL-2) therapyHigher acute rejection ratesLow-dose IL-2Face transplantationAcute rejection ratesCytotoxicity-associated genesDose interleukin-2Greater suppressive functionInterleukin-2 therapyAutoimmune hemolytic anemiaRegulatory T cellsNarrow therapeutic windowLife-changing procedureImmunological monitoringTim-3Peripheral bloodImmune modulationHemolytic anemiaFacial Expression after Face Transplant: An International Face Transplant Cohort Comparison
Dorante M, Wang A, Kollar B, Perry B, Ertosun M, Lindford A, Kiukas E, Özkan Ö, Özkan Ö, Lassus P, Pomahac B. Facial Expression after Face Transplant: An International Face Transplant Cohort Comparison. Plastic & Reconstructive Surgery 2023, 152: 315e-325e. PMID: 36727808, DOI: 10.1097/prs.0000000000010242.Peer-Reviewed Original ResearchConceptsFT patientsHealthy controlsMotor function restorationMotor functionFace transplantFunction restorationAge-matched healthy controlsCLINICAL QUESTION/LEVELInterpositional nerve graftFull face transplantRespective healthy controlsMotor outcomeNerve coaptationFemale patientsNerve graftsPatientsPercentage restorationCohort comparisonFacial proceduresBilateral testsTransplantScore valuesFacial movements
2022
Perioperative Outcomes and Risk Profile of 4730 Cosmetic Breast Surgery Cases in Academic Institutions: An ACS-NSQIP Analysis
Knoedler S, Kauke-Navarro M, Haug V, Broer P, Pomahac B, Knoedler L, Panayi A. Perioperative Outcomes and Risk Profile of 4730 Cosmetic Breast Surgery Cases in Academic Institutions: An ACS-NSQIP Analysis. Aesthetic Surgery Journal 2022, 43: 433-451. PMID: 36472232, DOI: 10.1093/asj/sjac320.Peer-Reviewed Original ResearchConceptsChronic obstructive pulmonary diseaseCosmetic breast surgeryObstructive pulmonary diseaseRisk factorsSurgical complicationsPulmonary diseaseSurgeons National Surgical Quality Improvement Program databaseNational Surgical Quality Improvement Program databaseMulti-institutional national databaseMultiple proceduresQuality Improvement Program databaseImprovement Program databaseIndependent risk factorCongestive heart failurePositive safety profileObesity class 1ACS-NSQIP AnalysisAnesthesiology scoreBreast surgery casesPerioperative outcomesPerioperative protocolPostoperative outcomesClinical patternHeart failureFemale patientsPatient-Reported Outcomes After Reduction Mammoplasty Using BREAST-Q: A Systematic Review and Meta-Analysis
Wang A, Panayi A, Fischer S, Diehm Y, Tapking C, Hundeshagen G, Kneser U, Mastroianni M, Pomahac B, Haug V. Patient-Reported Outcomes After Reduction Mammoplasty Using BREAST-Q: A Systematic Review and Meta-Analysis. Aesthetic Surgery Journal 2022, 43: np231-np241. PMID: 36411260, DOI: 10.1093/asj/sjac293.Peer-Reviewed Original Research