2001
Deficient long‐term synaptic depression in the rostral cerebellum correlated with impaired motor learning in phospholipase C β4 mutant mice
Miyata M, Kim H, Hashimoto K, Lee T, Cho S, Jiang H, Wu Y, Jun K, Wu D, Kano M, Shin H. Deficient long‐term synaptic depression in the rostral cerebellum correlated with impaired motor learning in phospholipase C β4 mutant mice. European Journal Of Neuroscience 2001, 13: 1945-1954. PMID: 11403688, DOI: 10.1046/j.0953-816x.2001.01570.x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAtaxiaBlinkingCalcium SignalingCerebellumConditioning, PsychologicalIsoenzymesLearningLong-Term PotentiationMiceMice, KnockoutMotor ActivityMutationNerve FibersNeural InhibitionPhospholipase C betaPurkinje CellsReceptors, Metabotropic GlutamateReference ValuesSynapsesSynaptic TransmissionType C PhospholipasesConceptsLong-term depressionRostral cerebellumMutant micePurkinje cellsMetabotropic glutamate receptor subtype 1Parallel fiber-Purkinje cell synapseParallel fiber-Purkinje cell synapsesLong-term synaptic depressionFiber-Purkinje cell synapseFiber-Purkinje cell synapsesMotor learningReceptor subtype 1Voltage-gated Ca2Wild-type miceParallel fiber stimulationEyeblink responseMost Purkinje cellsUnconditioned stimulusImpaired motorCell synapsesCaudal cerebellumSynaptic depressionCell synapseFiber stimulationSubtype 1
2000
Climbing fiber synapse elimination during postnatal cerebellar development requires signal transduction involving Gαq and phospholipase Cβ4
Hashimoto K, Watanabe M, Kurihara H, Offermanns S, Jiang H, Wu Y, Jun K, Shin H, Inoue Y, Wu D, Simon M, Kano M. Climbing fiber synapse elimination during postnatal cerebellar development requires signal transduction involving Gαq and phospholipase Cβ4. Progress In Brain Research 2000, 124: 31-48. PMID: 10943115, DOI: 10.1016/s0079-6123(00)24006-5.Peer-Reviewed Original ResearchAge FactorsAnimalsAtaxiaCell SizeCerebellumExcitatory Postsynaptic PotentialsGene Expression Regulation, DevelopmentalGene Expression Regulation, EnzymologicGTP-Binding Protein alpha Subunits, Gq-G11GTP-Binding ProteinsIsoenzymesMiceMice, Neurologic MutantsMicroscopy, ElectronNerve FibersOrgan Culture TechniquesPhospholipase C betaPurkinje CellsRNA, MessengerSignal TransductionSynapsesType C Phospholipases