Mitochondria as therapeutic targets in assisted reproduction
Yildirim R, Seli E. Mitochondria as therapeutic targets in assisted reproduction. Human Reproduction 2024, 39: 2147-2159. PMID: 39066614, DOI: 10.1093/humrep/deae170.Peer-Reviewed Original ResearchMitochondrial replacement therapyClinical trialsAssisted reproductionImprove oocyte qualityTherapeutic targetAssisted reproductive outcomesImprove assisted reproductive outcomesMitochondrial quality control mechanismsDevelopmental competenceOocyte qualityReplacement therapyProgrammed cell deathQuality control mechanismsPharmacological agentsTargeting mitochondrial functionCalcium homeostasisReproductive outcomesInhibitor rapamycinMammalian targetMaternal spindle transferAntioxidant coenzyme Q10Mitochondrial populationEmbryo developmentCoenzyme Q10Cell death