2021
Noninvasive prenatal testing in women undergoing in vitro fertilization with preimplantation genetic testing
Klimczak AM, Seli E, Scott RT. Noninvasive prenatal testing in women undergoing in vitro fertilization with preimplantation genetic testing. Current Opinion In Obstetrics & Gynecology 2021, 33: 184-187. PMID: 33797422, DOI: 10.1097/gco.0000000000000707.Peer-Reviewed Original ResearchConceptsPreimplantation genetic testingGenetic testingNoninvasive prenatal testing resultsPositive test resultsPrenatal screening toolPositive predictive valuePrenatal testing resultsPregnant womenEuploid embryosPredictive valueNoninvasive prenatal testingScreening toolWomenRecent evidenceIVFPrenatal testingPGTPregnancyPrevalencePrenatalTesting
2020
Interpretation of noninvasive prenatal testing results following in vitro fertilization and preimplantation genetic testing for aneuploidy
Klimczak AM, Reig A, Neal SA, Seli E, Scott RT. Interpretation of noninvasive prenatal testing results following in vitro fertilization and preimplantation genetic testing for aneuploidy. American Journal Of Obstetrics & Gynecology MFM 2020, 2: 100232. PMID: 33345935, DOI: 10.1016/j.ajogmf.2020.100232.Peer-Reviewed Original ResearchConceptsPositive noninvasive prenatal testingPositive predictive valuePreimplantation genetic testingNoninvasive prenatal testing resultsEuploid embryosPredictive valueGeneral populationGenetic testingNoninvasive prenatal testingPrenatal testing resultsDiagnostic testingUniversity-affiliated fertility centrePrenatal testingRetrospective cohort studyLow-risk populationSingle euploid embryoPostnatal diagnostic testingCohort studyNormal babiesFertility centerPatient cohortPrenatal diagnostic testingRisk populationsLower riskPatientsA multicenter, prospective, blinded, nonselection study evaluating the predictive value of an aneuploid diagnosis using a targeted next-generation sequencing–based preimplantation genetic testing for aneuploidy assay and impact of biopsy
Tiegs AW, Tao X, Zhan Y, Whitehead C, Kim J, Hanson B, Osman E, Kim TJ, Patounakis G, Gutmann J, Castelbaum A, Seli E, Jalas C, Scott RT. A multicenter, prospective, blinded, nonselection study evaluating the predictive value of an aneuploid diagnosis using a targeted next-generation sequencing–based preimplantation genetic testing for aneuploidy assay and impact of biopsy. Fertility And Sterility 2020, 115: 627-637. PMID: 32863013, DOI: 10.1016/j.fertnstert.2020.07.052.Peer-Reviewed Original ResearchConceptsPreimplantation genetic testingSustained implantationPredictive valueGenetic testingClinical outcomesTrophectoderm biopsyAge-matched control groupImpact of biopsyPGT-A resultsAntral follicle countRecurrent pregnancy lossBody mass indexDetectable adverse impactAneuploid resultsSecondary outcomesFertilization cyclesFollicle countPrimary outcomeMass indexUsable blastocystsBlastocyst transferFertility centerPregnancy lossClinical error ratesStudy groupKey metrics and processes for validating embryo diagnostics
Jalas C, Seli E, Scott RT. Key metrics and processes for validating embryo diagnostics. Fertility And Sterility 2020, 114: 16-23. PMID: 32505382, DOI: 10.1016/j.fertnstert.2020.04.053.Peer-Reviewed Original Research