2018
DNA methylation-based age prediction and telomere length in white blood cells and cumulus cells of infertile women with normal or poor response to ovarian stimulation
Morin SJ, Tao X, Marin D, Zhan Y, Landis J, Bedard J, Scott RT, Seli E. DNA methylation-based age prediction and telomere length in white blood cells and cumulus cells of infertile women with normal or poor response to ovarian stimulation. Aging 2018, 10: 3761-3773. PMID: 30530921, PMCID: PMC6326671, DOI: 10.18632/aging.101670.Peer-Reviewed Original ResearchConceptsChronologic agePremature reproductive agingReproductive-age womenWhite blood cellsOvarian stimulationInfertile womenOvarian responsePatient ageInfertile patientsAge womenPoor responseFollicular somatic cellsReproductive agingFertility treatmentCumulus cellsBlood cellsTelomere lengthAgeWomenPatientsStimulationWBCFemale ageRiskReproductive senescence
2015
Embryonic Poly(A)-Binding Protein (EPAB) Is Required for Granulosa Cell EGF Signaling and Cumulus Expansion in Female Mice
Yang CR, Lowther KM, Lalioti MD, Seli E. Embryonic Poly(A)-Binding Protein (EPAB) Is Required for Granulosa Cell EGF Signaling and Cumulus Expansion in Female Mice. Endocrinology 2015, 157: 405-416. PMID: 26492470, PMCID: PMC4701890, DOI: 10.1210/en.2015-1135.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBone Morphogenetic Protein 15Cell ProliferationCells, CulturedCoculture TechniquesCumulus CellsEpidermal Growth FactorErbB ReceptorsFemaleGranulosa CellsGrowth Differentiation Factor 9Luteinizing HormoneMAP Kinase Signaling SystemMice, KnockoutOocytesPhosphorylationPoly(A)-Binding ProteinsProtein Processing, Post-TranslationalReceptors, LHSignal TransductionConceptsEpidermal growth factorZygotic genome activationP90 ribosomal S6 kinaseBone morphogenetic protein 15Cumulus cellsRibosomal S6 kinaseImpaired oocyte maturationCumulus expansionGrowth differentiation factor 9Genome activationDifferentiation factor 9S6 kinaseEarly embryosTranslational activationEGF signalingEGF receptorFemale micePhosphorylated MEK1/2EGF treatmentBinding proteinFactor 9Cells exhibitOocyte maturationProteinProtein 15
2010
Identification and in Vitro Characterization of Follicle Stimulating Hormone (FSH) Receptor Variants Associated with Abnormal Ovarian Response to FSH
Gerasimova T, Thanasoula MN, Zattas D, Seli E, Sakkas D, Lalioti MD. Identification and in Vitro Characterization of Follicle Stimulating Hormone (FSH) Receptor Variants Associated with Abnormal Ovarian Response to FSH. The Journal Of Clinical Endocrinology & Metabolism 2010, 95: 529-536. PMID: 20061434, PMCID: PMC2840851, DOI: 10.1210/jc.2009-1304.Peer-Reviewed Original ResearchConceptsOvarian responseFSH receptorFSHR mRNAAbnormal ovarian responseOvarian stimulation protocolsForms of infertilityOocytes of womenExtracellular ligand-binding portionHormone receptor variantsOvarian hyperstimulationOvarian stimulationFSHR variantsPoor responseInfertility treatmentT cellsStimulation protocolFollicle growthFSHFertility clinicsCAMP activationCumulus cellsReceptor variantsGenetic causeRT-PCRWomen