2020
Tumor response and endogenous immune reactivity after administration of HER2 CAR T cells in a child with metastatic rhabdomyosarcoma
Hegde M, Joseph SK, Pashankar F, DeRenzo C, Sanber K, Navai S, Byrd TT, Hicks J, Xu ML, Gerken C, Kalra M, Robertson C, Zhang H, Shree A, Mehta B, Dakhova O, Salsman VS, Grilley B, Gee A, Dotti G, Heslop HE, Brenner MK, Wels WS, Gottschalk S, Ahmed N. Tumor response and endogenous immune reactivity after administration of HER2 CAR T cells in a child with metastatic rhabdomyosarcoma. Nature Communications 2020, 11: 3549. PMID: 32669548, PMCID: PMC7363864, DOI: 10.1038/s41467-020-17175-8.Peer-Reviewed Original ResearchConceptsHER2-CAR T cellsCAR T cellsT-cell infusionCAR T-cell infusionT cellsMetastatic rhabdomyosarcomaOngoing phase I trialPhase I trialT cell receptorSecond remissionI trialSerum autoantibodiesImmune reactivityDetectable diseaseTumor responseBone marrowResponse consolidationInfusionRhabdomyosarcomaImmunodominant clonesLymphodepletionRemissionPathway proteinsDiseaseMonths
2006
Intact T cell responses in ataxia telangiectasia
Pashankar F, Singhal V, Akabogu I, Gatti RA, Goldman FD. Intact T cell responses in ataxia telangiectasia. Clinical Immunology 2006, 120: 156-162. PMID: 16762595, DOI: 10.1016/j.clim.2006.04.568.Peer-Reviewed Original ResearchConceptsAtaxia telangiectasiaSingle-cell levelQuantitative real-time PCRReal-time PCRT patientsRecessive multisystem disorderOpportunistic infectionsCell functionT cellsAutosomal recessive multisystem disorderCell levelIntact T-cell responsesCD8 T cell subsetsSignificant immune abnormalitiesLevels of Th1T cell responsesT cell subsetsVariable immune deficiencyT cell functionFlow cytometryAnti-CD3 stimulationStimulated T cellsQuantitative defectsCellsImmune abnormalities