2017
Leveraging functional annotations in genetic risk prediction for human complex diseases
Hu Y, Lu Q, Powles R, Yao X, Yang C, Fang F, Xu X, Zhao H. Leveraging functional annotations in genetic risk prediction for human complex diseases. PLOS Computational Biology 2017, 13: e1005589. PMID: 28594818, PMCID: PMC5481142, DOI: 10.1371/journal.pcbi.1005589.Peer-Reviewed Original ResearchMeSH KeywordsChromosome MappingData Interpretation, StatisticalData MiningDatabases, GeneticEpigenomicsGenetic Association StudiesGenetic Predisposition to DiseaseGenetic VariationGenome, HumanHumansLinkage DisequilibriumPolymorphism, Single NucleotideProportional Hazards ModelsQuantitative Trait LociRisk AssessmentConceptsGenome-wide association studiesFunctional annotationGenetic risk predictionDisease-associated genetic variantsLinkage disequilibriumIdentification of thousandsWide association studyHuman complex diseasesComplex diseasesGWAS summary statisticsHuman genetics researchAssociation studiesAnnoPredGenotype dataGenetic researchGenetic variantsRelevant variantsAnnotationDisequilibriumMost diseasesDiverse typesSummary statisticsVariantsBayesian frameworkPrecision medicine
2015
A Statistical Framework to Predict Functional Non-Coding Regions in the Human Genome Through Integrated Analysis of Annotation Data
Lu Q, Hu Y, Sun J, Cheng Y, Cheung KH, Zhao H. A Statistical Framework to Predict Functional Non-Coding Regions in the Human Genome Through Integrated Analysis of Annotation Data. Scientific Reports 2015, 5: 10576. PMID: 26015273, PMCID: PMC4444969, DOI: 10.1038/srep10576.Peer-Reviewed Original ResearchConceptsHuman genomeFunctional regionsStatistical frameworkAnnotation dataFunctional annotation dataWhole-genome annotationNon-coding regionsGenomic conservationHigh-throughput experimentsENCODE projectExperimental annotationsGenomeUnsupervised statistical learningFunctional potentialHuman geneticsStatistical learningComputational predictionsIntegrated analysisAnnotationAnnotation methodDiverse typesPowerful toolGeneticsMajor goalWeb server