2011
Ribavirin Treatment Effects on Breast Cancers Overexpressing eIF4E, a Biomarker with Prognostic Specificity for Luminal B-Type Breast Cancer
Pettersson F, Yau C, Dobocan MC, Culjkovic-Kraljacic B, Retrouvay H, Puckett R, Flores LM, Krop IE, Rousseau C, Cocolakis E, Borden KL, Benz CC, Miller WH. Ribavirin Treatment Effects on Breast Cancers Overexpressing eIF4E, a Biomarker with Prognostic Specificity for Luminal B-Type Breast Cancer. Clinical Cancer Research 2011, 17: 2874-2884. PMID: 21415224, PMCID: PMC3086959, DOI: 10.1158/1078-0432.ccr-10-2334.Peer-Reviewed Original ResearchMeSH KeywordsAntimetabolites, AntineoplasticBiomarkers, TumorBreast NeoplasmsCarcinomaCell Line, TumorCells, CulturedEukaryotic Initiation Factor-4EFemaleGene Expression Regulation, NeoplasticGene Knockdown TechniquesHumansMammary Glands, HumanOrgan SpecificityPrognosisRibavirinRNA, Small InterferingUp-RegulationConceptsDistant metastasis-free survivalBreast cancer cell linesBreast cancerCancer cell linesLuminal B type breast cancerNode-negative breast cancerIntrinsic breast cancer subtypesPoor outcome groupMetastasis-free survivalLuminal B casesSpecific molecular subtypesCell proliferationBreast cancer subtypesCell linesBreast cancer cellsSpecific molecular profilePrognostic specificityMetastatic diseasePrognostic valuePrimary tumorCancer therapeutic strategiesOutcome groupSkin biopsiesMolecular subtypesPatient tumors
2005
A Putative Role for Psoriasin in Breast Tumor Progression
Krop I, März A, Carlsson H, Li X, Bloushtain-Qimron N, Hu M, Gelman R, Sabel MS, Schnitt S, Ramaswamy S, Kleer CG, Enerbäck C, Polyak K. A Putative Role for Psoriasin in Breast Tumor Progression. Cancer Research 2005, 65: 11326-11334. PMID: 16357139, DOI: 10.1158/0008-5472.can-05-1523.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisBiomarkers, TumorBreast NeoplasmsCalcium-Binding ProteinsCarcinoma, Intraductal, NoninfiltratingCollagenasesDisease ProgressionDown-RegulationFemaleHumansMatrix Metalloproteinase 13MiceMice, NudeNeovascularization, PathologicReceptors, EstrogenRNA, MessengerRNA, Small InterferingS100 Calcium Binding Protein A7S100 ProteinsTumor Cells, CulturedVascular Endothelial Growth Factor AConceptsReactive oxygen speciesInvasive breast carcinomaBreast tumor progressionVascular endothelial growth factorTumor progressionMitochondrial reactive oxygen speciesPsoriasin expressionStable short hairpin RNAShort hairpin RNAAnti-invasive functionPutative functionsHuman IBC cell linesEstrogen receptor-negative tumorsHuman invasive breast carcinomasHairpin RNAHigh psoriasin expressionIBC cell linesWorse clinical outcomesCell migrationPoor prognostic factorReceptor-negative tumorsPutative roleInhibits tumor growthMatrix metalloproteinase-13Cell proliferation