2009
Nuclear networking fashions pre-messenger RNA and primary microRNA transcripts for function
Pawlicki JM, Steitz JA. Nuclear networking fashions pre-messenger RNA and primary microRNA transcripts for function. Trends In Cell Biology 2009, 20: 52-61. PMID: 20004579, PMCID: PMC2821161, DOI: 10.1016/j.tcb.2009.10.004.Peer-Reviewed Original ResearchConceptsMature messenger RNAGene expressionRNA polymerase II transcriptsProtein-coding genesPolymerase II transcriptsRNA polymerase IIMessenger RNAPre-messenger RNARNA processing reactionsCotranscriptional eventsPolymerase IIProcessing eventsProcessing reactionsExtensive molecular interactionsEarly stepsTranscriptsRNAExquisite couplingMolecular interactionsMicroRNAsExpressionNuclear networkCrucial roleFinal fateSplicing
1988
snRNP mediators of 3′ end processing: functional fossils?
Mowry K, Steitz J. snRNP mediators of 3′ end processing: functional fossils? Trends In Biochemical Sciences 1988, 13: 447-451. PMID: 2908086, DOI: 10.1016/0968-0004(88)90220-4.Peer-Reviewed Original ResearchConceptsGene expression apparatusMRNA 3' end formationHistone mRNA 3' end formationEukaryotic messenger RNAsRNA processing reactionsRNA recognitionEnd formationRNA moleculesEnd processingProcessing reactionsBase pairsEarly evolutionMessenger RNASnRNPsCurrent understandingMajor playersPolyadenylationSplicingRNAFossilsSequenceMaturationMediators