2023
Sex and prior exposure jointly shape innate immune responses to a live herpesvirus vaccine
Cheung F, Apps R, Dropulic L, Kotliarov Y, Chen J, Jordan T, Langweiler M, Candia J, Biancotto A, Han K, Rachmaninoff N, Pietz H, Wang K, Tsang J, Cohen J. Sex and prior exposure jointly shape innate immune responses to a live herpesvirus vaccine. ELife 2023, 12: e80652. PMID: 36648132, PMCID: PMC9844983, DOI: 10.7554/elife.80652.Peer-Reviewed Original ResearchConceptsEarly innate responseVaccine recipientsPrior exposureInnate responseType I interferon signatureInfectious diseasesSeronegative vaccine recipientsType I IFN responseEarly antiviral responseNational InstituteInnate immune responseSystems immunology approachI IFN responseAdaptive immune phenotypesIntramural Research ProgramInterferon signatureAntibody titersVaccine trialsImmune phenotypeVirus vaccineNaive womenImmune responseSanofi PasteurDay 1Herpesvirus vaccine
2013
The National Institutes of Health Center for Human Immunology, Autoimmunity, and Inflammation: history and progress
Dickler H, McCoy J, Nussenblatt R, Perl S, Schwartzberg P, Tsang J, Wang E, Young N. The National Institutes of Health Center for Human Immunology, Autoimmunity, and Inflammation: history and progress. Annals Of The New York Academy Of Sciences 2013, 1285: 133-147. PMID: 23692568, DOI: 10.1111/nyas.12101.Peer-Reviewed Original ResearchConceptsHuman immunologyDepth clinical phenotypingCommon pathogenic pathwayNew therapeutic modalitiesHuman immune systemDisease progressionImmune cellsHealth centersClinical phenotypingTherapeutic modalitiesPathogenic pathwaysImmune systemNew interventionsMultiplex technologyPotential targetNational InstituteAutoimmunityInflammationEpigenetic modulationDiseaseImmunologyIntramural programsInterventionGene expressionDepth assessment