Featured Publications
Systematic Analysis of Cell-to-Cell Expression Variation of T Lymphocytes in a Human Cohort Identifies Aging and Genetic Associations
Lu Y, Biancotto A, Cheung F, Remmers E, Shah N, McCoy J, Tsang J. Systematic Analysis of Cell-to-Cell Expression Variation of T Lymphocytes in a Human Cohort Identifies Aging and Genetic Associations. Immunity 2016, 45: 1162-1175. PMID: 27851916, PMCID: PMC6532399, DOI: 10.1016/j.immuni.2016.10.025.Peer-Reviewed Original ResearchConceptsExpression variationDisease-associated genetic polymorphismsSingle-cell dataPrimary cell populationsCell populationsOrganismal levelFunctional associationDisease susceptibilityGenetic associationFlow cytometry dataCytometry dataGenetic polymorphismsHuman cohortsFlow cytometryCellsHigh-dimensional flow cytometryCell subpopulationsImportant rolePrevalent featureProteinPhenotypeSystematic analysisMultiple baseline measurementsPolymorphismPopulation
2018
Immune regulation by glucocorticoids can be linked to cell-lineage-specific transcriptional responses
Franco L, Gadkari M, Howe K, Sun J, Kumar P, Kardava L, Biancotto A, Hu Z, Fraser I, Moir S, Germain R, Tsang J. Immune regulation by glucocorticoids can be linked to cell-lineage-specific transcriptional responses. The Journal Of Immunology 2018, 200: 48.7-48.7. DOI: 10.4049/jimmunol.200.supp.48.7.Peer-Reviewed Original ResearchTranscriptional responseReceptor signalingSpecific transcriptional responsesGenome-wide approachesTotal RNA sequencingSmall RNA sequencingB-cell receptor signalingCell receptor signalingExpression of genesDependent transcriptional responsesPrimary cell populationsB cellsTranscriptional regulationIndividual genesRNA sequencingToll-like receptor signalingNegative regulatorKey moleculesB cell activationHuman B cellsSingle intravenous doseProtein levelsAnti-inflammatory drugsImmune pathwaysCell populations