2023
Inflammatory and interferon gene expression signatures in patients with mitochondrial disease
Warren E, Gordon-Lipkin E, Cheung F, Chen J, Mukherjee A, Apps R, Tsang J, Jetmore J, Schlein M, Kruk S, Lei Y, West A, McGuire P. Inflammatory and interferon gene expression signatures in patients with mitochondrial disease. Journal Of Translational Medicine 2023, 21: 331. PMID: 37208779, PMCID: PMC10199642, DOI: 10.1186/s12967-023-04180-w.Peer-Reviewed Original ResearchConceptsMTD patientsHealthy controlsMitochondrial dysfunctionAntiviral responseInterferon gene expression signatureChronic inflammatory disordersType I interferonCommon gene signaturePeripheral inflammationGene expression signaturesImmune dysregulationChronic inflammationMetabolic decompensationInflammatory disordersInterleukin-1βSymptom progressionT cellsInflammatory signalingMouse modelI interferonMitochondrial diseasePatientsTranslational evidenceMELAS patientsDysfunction
2019
Resident Macrophages Cloak Tissue Microlesions to Prevent Neutrophil-Driven Inflammatory Damage
Uderhardt S, Martins A, Tsang J, Lämmermann T, Germain R. Resident Macrophages Cloak Tissue Microlesions to Prevent Neutrophil-Driven Inflammatory Damage. Cell 2019, 177: 541-555.e17. PMID: 30955887, PMCID: PMC6474841, DOI: 10.1016/j.cell.2019.02.028.Peer-Reviewed Original ResearchConceptsTissue-resident macrophagesTissue homeostasisDiverse tissuesCell deathOrgan architectureIndividual cellsNeutrophil swarmsResident macrophagesDense swarmsLocal cell injuryIntravital imagingLocal disruptionParenchymal cell deathDynamic intravital imagingInescapable consequenceCell damageCell injuryHomeostasisMacrophagesCascadeInflammatory damageDamageCellsAccumulationDisruption
2016
Distinct NF-κB and MAPK Activation Thresholds Uncouple Steady-State Microbe Sensing from Anti-pathogen Inflammatory Responses
Gottschalk R, Martins A, Angermann B, Dutta B, Ng C, Uderhardt S, Tsang J, Fraser I, Meier-Schellersheim M, Germain R. Distinct NF-κB and MAPK Activation Thresholds Uncouple Steady-State Microbe Sensing from Anti-pathogen Inflammatory Responses. Cell Systems 2016, 2: 378-390. PMID: 27237739, PMCID: PMC4919147, DOI: 10.1016/j.cels.2016.04.016.Peer-Reviewed Original ResearchConceptsNF-κBMAPK activationInflammatory mediator productionSet of genesInnate immune response systemNF-κB signalingInnate immune systemSwitch-like mannerMacrophage functional responsesImmune response systemInflammatory mediatorsTLR4 ligandMediator productionInflammatory responseMicrobial stimuliInnate responseImmune systemMAPK signalingMacrophage primingLigand sensitivityHuman macrophagesInverse correlationInvasive pathogensSingle receptorGenes
2013
The National Institutes of Health Center for Human Immunology, Autoimmunity, and Inflammation: history and progress
Dickler H, McCoy J, Nussenblatt R, Perl S, Schwartzberg P, Tsang J, Wang E, Young N. The National Institutes of Health Center for Human Immunology, Autoimmunity, and Inflammation: history and progress. Annals Of The New York Academy Of Sciences 2013, 1285: 133-147. PMID: 23692568, DOI: 10.1111/nyas.12101.Peer-Reviewed Original ResearchConceptsHuman immunologyDepth clinical phenotypingCommon pathogenic pathwayNew therapeutic modalitiesHuman immune systemDisease progressionImmune cellsHealth centersClinical phenotypingTherapeutic modalitiesPathogenic pathwaysImmune systemNew interventionsMultiplex technologyPotential targetNational InstituteAutoimmunityInflammationEpigenetic modulationDiseaseImmunologyIntramural programsInterventionGene expressionDepth assessment