2001
The major murine systemic lupus erythematosus susceptibility locus, Sle1, is a cluster of functionally related genes
Morel L, Blenman K, Croker B, Wakeland E. The major murine systemic lupus erythematosus susceptibility locus, Sle1, is a cluster of functionally related genes. Proceedings Of The National Academy Of Sciences Of The United States Of America 2001, 98: 1787-1792. PMID: 11172029, PMCID: PMC29335, DOI: 10.1073/pnas.98.4.1787.Peer-Reviewed Original ResearchConceptsSusceptibility lociComplex trait lociCluster of genesFine-mapping analysisSystemic lupus erythematosus susceptibility lociTrait lociGenomic intervalsEpistatic interactionsModifier lociChromosomal regionsGenetic complexityAdditional lociLociCongenic analysisSusceptibility genesGenesCongenic intervalChromatinCellular characteristicsCell functionMapping analysisMultiple human studiesRelated functionsAutoimmune phenotypeSle1
2000
Genetic reconstitution of systemic lupus erythematosus immunopathology with polycongenic murine strains
Morel L, Croker B, Blenman K, Mohan C, Huang G, Gilkeson G, Wakeland E. Genetic reconstitution of systemic lupus erythematosus immunopathology with polycongenic murine strains. Proceedings Of The National Academy Of Sciences Of The United States Of America 2000, 97: 6670-6675. PMID: 10841565, PMCID: PMC18697, DOI: 10.1073/pnas.97.12.6670.Peer-Reviewed Original ResearchConceptsLoss of toleranceSystemic autoimmunityLupus-prone NZM2410 mouseFull disease expressionSevere systemic autoimmunitySystemic lupus erythematosusLupus-prone strainsLupus susceptibility genesFatal glomerulonephritisFatal lupusSevere glomerulonephritisLupus erythematosusKidney failureT cellsMurine strainsC57BL/6 backgroundB cellsAutoimmune phenotypeDisease pathogenesisNZM2410 miceTherapeutic interventionsFatal diseaseDisease expressionCongenic dissectionNuclear antigen