2016
Circulating Tumor Cell Phenotype Predicts Recurrence and Survival in Pancreatic Adenocarcinoma
Poruk KE, Valero V, Saunders T, Blackford AL, Griffin JF, Poling J, Hruban RH, Anders RA, Herman J, Zheng L, Rasheed ZA, Laheru DA, Ahuja N, Weiss MJ, Cameron JL, Goggins M, Iacobuzio-Donahue CA, Wood LD, Wolfgang CL. Circulating Tumor Cell Phenotype Predicts Recurrence and Survival in Pancreatic Adenocarcinoma. Annals Of Surgery 2016, 264: 1073-1081. PMID: 26756760, PMCID: PMC4936958, DOI: 10.1097/sla.0000000000001600.Peer-Reviewed Original ResearchConceptsCytokeratin-positive CTCsPancreatic adenocarcinomaMesenchymal markersVimentin-positive CTCsEpithelial tumor cells (ISET) methodFourth leading causeBetter treatment stratificationPortal blood samplesSignificant independent predictorsPotential prognostic biomarkerBiology of metastasisDetection of CTCsSurgical resectionIndependent predictorsPrognostic factorsMedian timeMultivariable analysisPDAC patientsPrognostic utilityCancer deathPatient prognosisLeading causeTreatment stratificationCancer recurrencePoor survival
2012
Young Patients Undergoing Resection of Pancreatic Cancer Fare Better than their Older Counterparts
He J, Edil BH, Cameron JL, Schulick RD, Hruban RH, Herman JM, Zheng L, Iacobuzio-Donahue C, Ahuja N, Pawlik TM, Wolfgang CL. Young Patients Undergoing Resection of Pancreatic Cancer Fare Better than their Older Counterparts. Journal Of Gastrointestinal Surgery 2012, 17: 339-344. PMID: 23184271, PMCID: PMC3600849, DOI: 10.1007/s11605-012-2066-4.Peer-Reviewed Original ResearchConceptsCharlson-Age Comorbidity IndexOlder age groupsDate of surgeryYounger patientsOlder patientsAge groupsMedian agePDAC patientsPancreatic ductal adenocarcinoma patientsPatients Undergoing ResectionMedian overall survivalResectable pancreatic cancerLymph node positivityYoung patient cohortDuctal adenocarcinoma patientsYounger age groupsCurative resectionUndergoing resectionAbdominal painDistal pancreatectomyR0 resectionTotal pancreatectomyUnderwent pancreaticoduodenectomyElderly patientsNode positivity