1995
Age-dependent Alterations in beta-adrenergic Responsiveness of Rat Detrusor Smooth Muscle
Nishimoto T, Latifpour J, Wheeler M, Yoshida M, Weiss R. Age-dependent Alterations in beta-adrenergic Responsiveness of Rat Detrusor Smooth Muscle. Journal Of Urology 1995, 153: 1701-1705. PMID: 7715014, DOI: 10.1016/s0022-5347(01)67508-6.Peer-Reviewed Original ResearchConceptsElectrical field stimulationMaximum relaxant responseBeta-adrenergic receptorsMuscle stripsRelaxant responsesRelaxant effectTonic contractionMaximal KCl-induced contractionRat detrusor smooth muscleAge groupsMale Fischer 344 ratsDetrusor muscle stripsEFS-induced contractionsKCl-induced contractionBeta-adrenergic responsivenessDetrusor smooth muscleFischer 344 ratsBeta-adrenergic stimulationAge-dependent alterationsAge-related decreaseCyclic AMP productionDibutyryl cyclic AMPRat detrusorPhasic contractionsBladder detrusorAge-dependent Alterations in beta-adrenergic Responsiveness of Rat Detrusor Smooth Muscle
Nishimoto T, Latifpour J, Wheeler M, Yoshida M, Weiss R. Age-dependent Alterations in beta-adrenergic Responsiveness of Rat Detrusor Smooth Muscle. Journal Of Urology 1995, 153: 1701-1705.. DOI: 10.1097/00005392-199505000-00105.Peer-Reviewed Original ResearchElectrical field stimulationMaximum relaxant responseBeta-adrenergic receptorsMuscle stripsRelaxant responsesRelaxant effectTonic contractionMaximal KCl-induced contractionRat detrusor smooth muscleAge groupsCholera toxinMale Fischer 344 ratsDetrusor muscle stripsEFS-induced contractionsKCl-induced contractionBeta-adrenergic responsivenessDetrusor smooth muscleFischer 344 ratsBeta-adrenergic stimulationAge-dependent alterationsAge-related decreaseCyclic AMP productionDibutyryl cyclic AMPRat detrusorPhasic contractions
1991
Differential Regulation of Bladder β-Adrenergic and Muscarinic Cholinergic Receptors in Experimental Diabetes
Latifpour J, Nishimoto T, Marian M, Yoshida M, Weiss R. Differential Regulation of Bladder β-Adrenergic and Muscarinic Cholinergic Receptors in Experimental Diabetes. Diabetes 1991, 40: 1150-1156. PMID: 1657672, DOI: 10.2337/diab.40.9.1150.Peer-Reviewed Original ResearchConceptsBeta-adrenergic receptorsSucrose-fed ratsBladder domeDetrusor stripsDiabetic ratsHigher serum glucose levelsLower serum insulin levelsLarger contractile responsesMuscarinic receptor upregulationHigher urine outputCarbachol-induced contractionDiabetes-induced alterationsMuscarinic cholinergic receptorsSerum insulin levelsSTZ-induced diabetesSerum glucose levelsIsoproterenol-induced relaxationAge-matched controlsLower body weightSucrose-fed animalsBladder hypertrophyContractile responseDiabetic bladderUrine outputRelaxed KClBeta adrenergic receptor alterations in diabetic rat prostate: Effects of insulin and dietary myoinositol
Gousse A, Yoshida M, Weiss R, Latifpour J. Beta adrenergic receptor alterations in diabetic rat prostate: Effects of insulin and dietary myoinositol. The Prostate 1991, 19: 121-131. PMID: 1681523, DOI: 10.1002/pros.2990190205.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic beta-AntagonistsAnimalsBlood GlucoseBody WeightDiabetes Mellitus, ExperimentalDihydroalprenololDose-Response Relationship, DrugDrinkingInositolInsulinIsoproterenolMaleOrgan SizePropanolaminesPropranololProstateRadioligand AssayRatsRats, Inbred StrainsReceptors, Adrenergic, betaStreptozocinUrinationConceptsBeta-adrenergic receptorsAdrenergic receptorsInsulin levelsRadioligand receptor binding techniquesSelective beta-adrenergic antagonistsHigh blood glucose levelsLower serum insulin levelsAdrenergic receptor alterationsInduction of diabetesInsulin-treated diabeticsSerum insulin levelsBeta-adrenergic receptor alterationsAutonomic nervous systemBlood glucose levelsBeta-adrenergic antagonistsDiabetic rat prostateGroups of ratsReceptor binding techniquesEffect of insulinMale reproductive systemHigh water intakeDietary myoinositolDiabetes mellitusUrine outputDiabetic rats
1990
Autonomic receptors in urinary tract: sex and age differences.
Latifpour J, Kondo S, O'Hollaren B, Morita T, Weiss R. Autonomic receptors in urinary tract: sex and age differences. Journal Of Pharmacology And Experimental Therapeutics 1990, 253: 661-7. PMID: 2338651.Peer-Reviewed Original ResearchConceptsAlpha-2 adrenergic receptorsBladder domeBladder baseBeta-adrenergic receptorsAdrenergic receptorsCholinergic receptorsMuscarinic receptorsUrinary tractAlpha-2 adrenergic receptor densityLower urinary tract smooth muscleUrinary tract smooth muscleRabbit bladder baseAlpha 2A subtypeMuscarinic cholinergic receptorsAdrenergic receptor densityLower urinary tractSelective adrenergic agonistsAdult rat cortexNeonatal rat lungBeta-2 adrenergic receptorsAutonomic receptorsAge-related differencesRat cortexAdrenergic agonistsMale urethra
1989
The Characterization of Beta-Adrenergic Receptor Subtypes of the Upper and Lower Renal Pelvis in Rabbits
Kondo S, Latifpour J, Morita T, Weiss R. The Characterization of Beta-Adrenergic Receptor Subtypes of the Upper and Lower Renal Pelvis in Rabbits. Journal Of Urology 1989, 142: 1099-1101. PMID: 2571737, DOI: 10.1016/s0022-5347(17)39004-3.Peer-Reviewed Original ResearchConceptsBeta-adrenergic receptorsBeta 2 subtypeRenal pelvisRabbit renal pelvisLower pelvisSelective antagonistBeta-2 selective antagonistBeta-adrenergic receptor subtypesUpper renal pelvisBeta 2 receptorsRadioligand binding techniquesBeta-1 selective antagonistReceptor subtypesBeta receptorsPelvisBeta 1ReceptorsSubtypesICIBinding techniquesSaturation studiesSignificant differencesSites BmaxAntagonistGreater proportion
1986
Relaxant Effect of Forskolin in Rabbit Detrusor Smooth Muscle: Role of Cyclic AMP
Morita T, Wheeler M, Weiss R. Relaxant Effect of Forskolin in Rabbit Detrusor Smooth Muscle: Role of Cyclic AMP. Journal Of Urology 1986, 135: 1293-1295. PMID: 3012124, DOI: 10.1016/s0022-5347(17)46077-0.Peer-Reviewed Original ResearchConceptsDetrusor muscleRelaxant effectRabbit detrusor muscle stripsDetrusor muscle relaxationDetrusor muscle stripsRabbit detrusor muscleConcentration-dependent relaxationDetrusor smooth muscleRabbit detrusor smooth muscleBeta-adrenergic antagonistsBeta-adrenergic receptorsCyclic AMPCyclic AMP levelsAdenylate cyclase inhibitorRabbit detrusorMuscle stripsMuscle relaxationSmooth muscleCyclase inhibitorPhosphodiesterase inhibitorRelaxation responseAMP levelsAdenylate cyclaseDependent relaxationForskolin
1978
Ureteral function
Weiss R. Ureteral function. Urology 1978, 12: 114-133. PMID: 211688, DOI: 10.1016/0090-4295(78)90321-7.Peer-Reviewed Original ResearchConceptsUreteral functionBeta-adrenergic receptor mechanismVesico-ureteral refluxElectrical activitySmooth muscle relaxationUreteral peristaltic activityBeta-adrenergic receptorsUrinary collecting systemExcitation-contraction couplingAge-dependent factorsUreteral contractionsUreteral lengthUreteral activityIntracellular storage sitesMuscle relaxationReceptor mechanismsPeristaltic activityAction potentialsUreterPacemaker siteProximal portionCollecting systemContractile proteinsCell membraneContractile process