2000
Alterations in G-proteins and beta-adrenergic responsive adenylyl cyclase in rat urinary bladder during aging.
Derweesh I, Wheeler M, Weiss R. Alterations in G-proteins and beta-adrenergic responsive adenylyl cyclase in rat urinary bladder during aging. Journal Of Pharmacology And Experimental Therapeutics 2000, 294: 969-74. PMID: 10945848.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine Diphosphate RiboseAdenylate Cyclase ToxinAdenylyl CyclasesAdrenergic beta-AgonistsAgingAnimalsBlotting, WesternCarbazolesColforsinCyclic AMPCyclic AMP-Dependent Protein KinasesEnzyme InhibitorsGTP-Binding ProteinsIndolesIsoproterenolMuscle, SmoothPertussis ToxinPyrrolesRatsReceptors, Adrenergic, betaUrinary BladderVirulence Factors, BordetellaConceptsPertussis toxin-catalyzed ADP-ribosylationToxin-catalyzed ADP-ribosylationRat bladderPertussis toxin-sensitive G proteinToxin-sensitive G proteinResponses of bladdersRat urinary bladderAdenylyl cyclaseTreatment of bladderBeta-adrenergic stimulationADP-ribosylationG proteinsAdenylyl cyclase activityResponsive adenylyl cyclaseAge-dependent declineWestern blot analysisG-protein contentUrinary bladderPertussis toxinBladderIsoproterenol stimulationRelaxation responseCyclase activityFunctional activityBlot analysis
1995
Age-dependent Alterations in beta-adrenergic Responsiveness of Rat Detrusor Smooth Muscle
Nishimoto T, Latifpour J, Wheeler M, Yoshida M, Weiss R. Age-dependent Alterations in beta-adrenergic Responsiveness of Rat Detrusor Smooth Muscle. Journal Of Urology 1995, 153: 1701-1705. PMID: 7715014, DOI: 10.1016/s0022-5347(01)67508-6.Peer-Reviewed Original ResearchConceptsElectrical field stimulationMaximum relaxant responseBeta-adrenergic receptorsMuscle stripsRelaxant responsesRelaxant effectTonic contractionMaximal KCl-induced contractionRat detrusor smooth muscleAge groupsMale Fischer 344 ratsDetrusor muscle stripsEFS-induced contractionsKCl-induced contractionBeta-adrenergic responsivenessDetrusor smooth muscleFischer 344 ratsBeta-adrenergic stimulationAge-dependent alterationsAge-related decreaseCyclic AMP productionDibutyryl cyclic AMPRat detrusorPhasic contractionsBladder detrusor
1991
Differential Regulation of Bladder β-Adrenergic and Muscarinic Cholinergic Receptors in Experimental Diabetes
Latifpour J, Nishimoto T, Marian M, Yoshida M, Weiss R. Differential Regulation of Bladder β-Adrenergic and Muscarinic Cholinergic Receptors in Experimental Diabetes. Diabetes 1991, 40: 1150-1156. PMID: 1657672, DOI: 10.2337/diab.40.9.1150.Peer-Reviewed Original ResearchConceptsBeta-adrenergic receptorsSucrose-fed ratsBladder domeDetrusor stripsDiabetic ratsHigher serum glucose levelsLower serum insulin levelsLarger contractile responsesMuscarinic receptor upregulationHigher urine outputCarbachol-induced contractionDiabetes-induced alterationsMuscarinic cholinergic receptorsSerum insulin levelsSTZ-induced diabetesSerum glucose levelsIsoproterenol-induced relaxationAge-matched controlsLower body weightSucrose-fed animalsBladder hypertrophyContractile responseDiabetic bladderUrine outputRelaxed KClDifferential regulation of bladder beta-adrenergic and muscarinic cholinergic receptors in experimental diabetes
Latifpour J, Nishimoto T, Marian M, Yoshida M, Weiss R. Differential regulation of bladder beta-adrenergic and muscarinic cholinergic receptors in experimental diabetes. Diabetes 1991, 40: 1150-1156. DOI: 10.2337/diabetes.40.9.1150.Peer-Reviewed Original ResearchBeta adrenergic receptor alterations in diabetic rat prostate: Effects of insulin and dietary myoinositol
Gousse A, Yoshida M, Weiss R, Latifpour J. Beta adrenergic receptor alterations in diabetic rat prostate: Effects of insulin and dietary myoinositol. The Prostate 1991, 19: 121-131. PMID: 1681523, DOI: 10.1002/pros.2990190205.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic beta-AntagonistsAnimalsBlood GlucoseBody WeightDiabetes Mellitus, ExperimentalDihydroalprenololDose-Response Relationship, DrugDrinkingInositolInsulinIsoproterenolMaleOrgan SizePropanolaminesPropranololProstateRadioligand AssayRatsRats, Inbred StrainsReceptors, Adrenergic, betaStreptozocinUrinationConceptsBeta-adrenergic receptorsAdrenergic receptorsInsulin levelsRadioligand receptor binding techniquesSelective beta-adrenergic antagonistsHigh blood glucose levelsLower serum insulin levelsAdrenergic receptor alterationsInduction of diabetesInsulin-treated diabeticsSerum insulin levelsBeta-adrenergic receptor alterationsAutonomic nervous systemBlood glucose levelsBeta-adrenergic antagonistsDiabetic rat prostateGroups of ratsReceptor binding techniquesEffect of insulinMale reproductive systemHigh water intakeDietary myoinositolDiabetes mellitusUrine outputDiabetic rats
1990
Changes in lipid composition and isoproterenol- and ethanol-stimulated adenylate cyclase activity in aging Fischer rat bladders.
Wheeler M, Pontari M, Nishimoto T, Weiss R. Changes in lipid composition and isoproterenol- and ethanol-stimulated adenylate cyclase activity in aging Fischer rat bladders. Journal Of Pharmacology And Experimental Therapeutics 1990, 254: 277-83. PMID: 2366184.Peer-Reviewed Original Research
1987
Ureteral Urine Transport: Changes in Bolus Volume, Peristaltic Frequency, Intraluminal Pressure and Volume of Flow Resulting from Autonomic Drugs
Morita T, Wada I, Saeki H, Tsuchida S, Weiss R. Ureteral Urine Transport: Changes in Bolus Volume, Peristaltic Frequency, Intraluminal Pressure and Volume of Flow Resulting from Autonomic Drugs. Journal Of Urology 1987, 137: 132-135. PMID: 3795356, DOI: 10.1016/s0022-5347(17)43904-8.Peer-Reviewed Original ResearchConceptsUreteral peristaltic frequencyPeristaltic frequencyContractile pressureBolus volumeIntraluminal pressureAutonomic nervous systemAutonomic agonistsAutonomic drugsNervous systemBaseline pressureExperimental modelSmall decreaseUrine transportBaselineResultant decreaseBolus formationFlow volumeElevationFluid transportNorepinephrineAcetylcholineDecreaseUreterAgonistsIsoproterenol
1986
Age dependence of adenylate cyclase in guinea pig ureter homogenate.
Wheeler M, Housman A, Cho Y, Weiss R. Age dependence of adenylate cyclase in guinea pig ureter homogenate. Journal Of Pharmacology And Experimental Therapeutics 1986, 239: 99-103. PMID: 3761201.Peer-Reviewed Original ResearchEffects of Noradrenaline, Isoproterenol and Acetylcholine on Ureteral Resistance
Morita T, Wheeler M, Weiss R. Effects of Noradrenaline, Isoproterenol and Acetylcholine on Ureteral Resistance. Journal Of Urology 1986, 135: 1296-1298. PMID: 3712589, DOI: 10.1016/s0022-5347(17)46078-2.Peer-Reviewed Original ResearchCharacterization of Functional Beta-Adrenoceptor Subtypes in Rabbit Urinary Bladder Smooth Muscle
MORITA T, KONDO S, TSUCHIDA S, WEISS R. Characterization of Functional Beta-Adrenoceptor Subtypes in Rabbit Urinary Bladder Smooth Muscle. The Tohoku Journal Of Experimental Medicine 1986, 149: 389. PMID: 3022421, DOI: 10.1620/tjem.149.389.Peer-Reviewed Original ResearchConceptsTrigonal muscleRelaxant responsesM isoproterenolRabbit urinary bladder smooth muscleUrinary bladder smooth muscleSignificant relaxant responseSpontaneous contractile forceUrinary bladder domeBeta-adrenoceptor subtypesBeta-adrenoceptor agonistsBeta-adrenoceptor stimulationMaximum relaxant responseBladder smooth muscleM butoxamineM metoprololSelective betaBladder domeMuscle stripsM propranololSpecific betaDetrusorSmooth muscleMale rabbitsIsoproterenolContractile forceウサギ膀胱平滑筋切片の張力に対する isoproterenol の作用
征男 宮, Morita T, Weiss R. ウサギ膀胱平滑筋切片の張力に対する isoproterenol の作用. The Japanese Journal Of Urology 1986, 77: 495-500. PMID: 3735875, DOI: 10.5980/jpnjurol1928.77.3_495.Peer-Reviewed Original Research
1985
Effect of Isoproterenol on Contractile Force of Isolated Rabbit Renal Pelvic Smooth Muscle
MORITA T, MIYAGAWA I, WHEELER M, WEISS R. Effect of Isoproterenol on Contractile Force of Isolated Rabbit Renal Pelvic Smooth Muscle. The Tohoku Journal Of Experimental Medicine 1985, 147: 153. PMID: 4082174, DOI: 10.1620/tjem.147.153.Peer-Reviewed Original Research摘出ウサギ腎盂平滑筋切片における自発収縮発生と自発収縮張力に及ぼす isoproterenol の作用
隆 森, 征男 宮, Wheeler M, Weiss R. 摘出ウサギ腎盂平滑筋切片における自発収縮発生と自発収縮張力に及ぼす isoproterenol の作用. The Japanese Journal Of Urology 1985, 76: 1381-1385. PMID: 4087631, DOI: 10.5980/jpnjurol1928.76.9_1381.Peer-Reviewed Original Research