2020
Cutaneous Involvement by Mantle Cell Lymphoma: Expanding the Spectrum of Histopathologic Findings in a Series of 9 Cases.
Panse G, Cowper S, Ko CJ, Subtil A. Cutaneous Involvement by Mantle Cell Lymphoma: Expanding the Spectrum of Histopathologic Findings in a Series of 9 Cases. American Journal Of Dermatopathology 2020, 42: 848-853. PMID: 32675465, DOI: 10.1097/dad.0000000000001742.Peer-Reviewed Case Reports and Technical NotesConceptsMantle cell lymphomaCutaneous involvementCell lymphomaSystemic mantle cell lymphomaAggressive B-cell neoplasmSingle institutional seriesSame biopsy specimenSite of involvementMarginal zone lymphomaB-cell neoplasmsImmunoglobulin M expressionSurface IgM expressionInstitutional seriesSecond malignanciesSystemic involvementClinicopathologic featuresCutaneous lesionsSitu hybridization studiesBiopsy specimenHistopathologic findingsMetastatic melanomaFirst manifestationDirect immunofluorescenceHematolymphoid neoplasmsTissue manifestationsHigh-throughput quantitative histology in systemic sclerosis skin disease using computer vision
Correia C, Mawe S, Lofgren S, Marangoni RG, Lee J, Saber R, Aren K, Cheng M, Teaw S, Hoffmann A, Goldberg I, Cowper SE, Khatri P, Hinchcliff M, Mahoney JM. High-throughput quantitative histology in systemic sclerosis skin disease using computer vision. Arthritis Research & Therapy 2020, 22: 48. PMID: 32171325, PMCID: PMC7071594, DOI: 10.1186/s13075-020-2127-0.Peer-Reviewed Original ResearchConceptsSystemic sclerosisFibrosis scoreQuantitative image featuresBiopsy scorePrimary cohortOutcome measuresSecondary cohortDiagnostic scoreSkin severity scoreSSc clinical trialsRodnan skin scoreLogistic regression modelsControl biopsiesRegression modelsSkin scoreSeverity scoreClinical hallmarkClinical trialsForearm biopsiesSSc skinBiopsy sectionsIndependent cohortPatient basisSSc biopsiesCollagen deposition
2019
Lobular neutrophilic panniculitis associated with DNA methyltransferase inhibitors in the treatment of myeloid disease
Coleman E, Panse G, Cowper S, Prebet T, Gore S, Leventhal J. Lobular neutrophilic panniculitis associated with DNA methyltransferase inhibitors in the treatment of myeloid disease. Journal Of Cutaneous Pathology 2019, 46: 930-934. PMID: 31254406, DOI: 10.1111/cup.13537.Peer-Reviewed Original ResearchConceptsLobular neutrophilic panniculitisNeutrophilic panniculitisDNA methyltransferase inhibitorNeutrophilic eccrine hidradenitisInjection site reactionsAcute myelogenous leukemiaMethyltransferase inhibitorNeutrophilic dermatosisSweet's syndromeMaculopapular eruptionCutaneous toxicityHistopathologic characteristicsSite reactionsNext-generation agentsDifferential diagnosisMyelogenous leukemiaTreatment considerationsMyeloid diseasesPanniculitisTreatmentInhibitorsFirst reportGangrenosumHidradenitisEcchymosis
2018
Detection of Borrelia in Ixodes scapularis ticks by silver stain, immunohistochemical and direct immunofluorescent methods
Galan A, Kupernik P, Cowper SE. Detection of Borrelia in Ixodes scapularis ticks by silver stain, immunohistochemical and direct immunofluorescent methods. Journal Of Cutaneous Pathology 2018, 45: 473-477. PMID: 29569269, DOI: 10.1111/cup.13143.Peer-Reviewed Original ResearchConceptsDirect immunofluorescent methodLyme diseaseImmunofluorescent methodSilver stainScapularis ticksPercentage of positivityRate of infectionCommon tick-borne diseasesIdentification of spirochetesDetection of BorreliaIxodes scapularis ticksClinical presentationRoutine biopsyClinical managementSkin biopsiesI. scapularis ticksConnecticut Agricultural Experiment StationTick-borne diseasesTick attachmentTimely identificationBiopsyDiseaseBorreliaSpirochetesStain
2017
A 71‐year‐old man with a hemorrhagic vesicular eruption
Hamilton CE, King BA, Cowper SE, Hochster H, Leventhal JS. A 71‐year‐old man with a hemorrhagic vesicular eruption. International Journal Of Dermatology 2017, 57: 147-148. PMID: 29057466, DOI: 10.1111/ijd.13793.Peer-Reviewed Case Reports and Technical NotesWell‐differentiated neuroendocrine tumors in skin: Terminology and diagnostic utility of cytokeratin 5/6 and p63
Panse G, Cowper SE, Leffell DJ, Pulitzer M, Ko CJ. Well‐differentiated neuroendocrine tumors in skin: Terminology and diagnostic utility of cytokeratin 5/6 and p63. Journal Of Cutaneous Pathology 2017, 44: 557-562. PMID: 28417484, DOI: 10.1111/cup.12952.Peer-Reviewed Original ResearchConceptsCutaneous adnexal neoplasmsAdnexal neoplasmsNeuroendocrine tumorsAdnexal tumorsBenign skin adnexal tumorCutaneous adnexal tumorsAggressive metastatic diseaseLow-grade tumorsSkin adnexal tumorsMajority of casesMetastatic diseaseMetastatic adenocarcinomaCarcinoid tumorsCytokeratin 5/6Diagnostic challengeDifferential diagnosisImmunohistochemical stainsCK5/6Diagnostic utilityPrimary siteTumorsNeoplasmsFirst signWDNETsP63
2014
Advancing pharmacovigilance through academic–legal collaboration: the case of gadolinium-based contrast agents and nephrogenic systemic fibrosis—a research on adverse drug events and reports (RADAR) report
Edwards BJ, Laumann AE, Nardone B, Miller FH, Restaino J, Raisch DW, McKoy JM, Hammel JA, Bhatt K, Bauer K, Samaras AT, Fisher MJ, Bull C, Saddleton E, Belknap SM, Thomsen HS, Kanal E, Cowper SE, Abu Alfa AK, West DP. Advancing pharmacovigilance through academic–legal collaboration: the case of gadolinium-based contrast agents and nephrogenic systemic fibrosis—a research on adverse drug events and reports (RADAR) report. British Journal Of Radiology 2014, 87: 20140307. PMID: 25230161, PMCID: PMC4170864, DOI: 10.1259/bjr.20140307.Peer-Reviewed Original ResearchConceptsGadolinium-based contrast agentsAdverse drug eventsDrug eventsMedicines AgencyGadopentetate dimeglumineDrug Administration Adverse Event Reporting SystemAdverse Event Reporting SystemDanish Medicines AgencyNephrogenic systemic fibrosisEvent Reporting SystemEuropean Medicines AgencyNSF casesHistopathological dataContrast agentsSystemic fibrosisDrug AdministrationLegal data setsUnconfounded casesGadobenate dimeglumineMean numberDimeglumineReporting systemPharmacovigilance researchSafety informationPharmacovigilanceDiagnosing nephrogenic systemic fibrosis in the post‐FDA restriction era
Thomson LK, Thomson PC, Kingsmore DB, Blessing K, Daly CD, Cowper SE, Roditi GH. Diagnosing nephrogenic systemic fibrosis in the post‐FDA restriction era. Journal Of Magnetic Resonance Imaging 2014, 41: 1268-1271. PMID: 24903851, DOI: 10.1002/jmri.24664.Peer-Reviewed Original Research
2013
Pediatric nephrogenic systemic fibrosis is rarely reported: a RADAR report
Nardone B, Saddleton E, Laumann AE, Edwards BJ, Raisch DW, McKoy JM, Belknap SM, Bull C, Haryani A, Cowper SE, Abu-Alfa AK, Miller FH, Godinez-Puig V, Dharnidharka VR, West DP. Pediatric nephrogenic systemic fibrosis is rarely reported: a RADAR report. Pediatric Radiology 2013, 44: 173-180. PMID: 24057195, PMCID: PMC3946726, DOI: 10.1007/s00247-013-2795-x.Peer-Reviewed Original ResearchConceptsNephrogenic systemic fibrosisSystemic fibrosisGadolinium-based contrast agentsDrug Administration Adverse Event Reporting SystemAdverse Event Reporting SystemEvent Reporting SystemRenal functionPediatric casesResearch RegistryContrast agentsFibrosisDuplicate reportingU.S. FoodSystematic searchReported numberRegistryChildrenReporting systemFAERSExposureReportAgentsMethodsWeCasesCase experience of 308-nm excimer laser therapy compatibility with PUVA and oral bexarotene for the treatment of cutaneous lesions in mycosis fungoides.
Huang J, Cowper S, Moss J, Girardi M. Case experience of 308-nm excimer laser therapy compatibility with PUVA and oral bexarotene for the treatment of cutaneous lesions in mycosis fungoides. Journal Of Drugs In Dermatology 2013, 12: 487-9. PMID: 23652902.Peer-Reviewed Case Reports and Technical NotesConceptsExcimer laser therapyOral bexaroteneLaser therapyMycosis fungoides lesionsMinimal side effectsMF plaquesLocal erythemaMycosis fungoidesTreatment regimenCutaneous lesionsMF lesionsHistologic resolutionSide effectsTherapyBexaroteneLesionsUltraviolet ARegimenPUVAPatientsTreatmentPlaquesCase experienceFungoidesErythema
2012
Linking Drugs to Obscure Illnesses: Lessons from Pure Red Cell Aplasia, Nephrogenic Systemic Fibrosis, and Reye’s Syndrome. A Report From the Southern Network on Adverse Reactions (SONAR)
Bennett CL, Starko KM, Thomsen HS, Cowper S, Sartor O, Macdougall IC, Qureshi ZP, Bookstaver PB, Miller AD, Norris LB, Xirasagar S, Trenery A, Lopez I, Kahn A, Murday A, Luminari S, Cournoyer D, Locatelli F, Ray P, Mattison DR. Linking Drugs to Obscure Illnesses: Lessons from Pure Red Cell Aplasia, Nephrogenic Systemic Fibrosis, and Reye’s Syndrome. A Report From the Southern Network on Adverse Reactions (SONAR). Journal Of General Internal Medicine 2012, 27: 1697-1703. PMID: 22692632, PMCID: PMC3509314, DOI: 10.1007/s11606-012-2098-1.ChaptersConceptsPure red cell aplasiaNephrogenic systemic fibrosisChronic kidney disease patientsSerious adverse drug reactionsKidney disease patientsRed cell aplasiaReye's syndromeNSF casesCell aplasiaDisease patientsSystemic fibrosisAdministration of aspirinDanish Medicines AgencyAdverse drug reactionsYears of identificationCKD patientsCounter medicationsDrug reactionsAdverse reactionsGadodiamide administrationObscure illnessPediatric useMedicines AgencyPatientsSyndrome
2011
Mycosis fungoides exhibiting features of a dermatofibroma: a case report and review of the literature
Morcos SM, Girardi M, Subtil A, Wilson LD, Cowper SE. Mycosis fungoides exhibiting features of a dermatofibroma: a case report and review of the literature. Journal Of Cutaneous Pathology 2011, 39: 40-46. PMID: 22059953, DOI: 10.1111/j.1600-0560.2011.01804.x.Peer-Reviewed Case Reports and Technical NotesConceptsMycosis fungoidesLesions of MFStage IA mycosis fungoidesUnusual clinical presentationLarge cell transformationClinical cluesClinical presentationDermal lymphocytesPatient populationFibrohistiocytic proliferationCase reportClinical managementAtypical lesionsRight forearmSuspicious tumorsBenign lesionsLesionsFungoidesDermatofibromaPatientsPrognosisLymphocytesTumorsIntraepidermalPlaques
2010
Squamoid Eccrine Ductal Carcinoma: A Case Report and Review of the Literature
Terushkin E, Leffell DJ, Futoryan T, Cowper S, Lazova R. Squamoid Eccrine Ductal Carcinoma: A Case Report and Review of the Literature. American Journal Of Dermatopathology 2010, 32: 287-292. PMID: 20010402, DOI: 10.1097/dad.0b013e3181b623c4.Peer-Reviewed Case Reports and Technical NotesConceptsDuctal carcinomaShave biopsyEccrine ductal carcinomaInitial shave biopsySuperficial shave biopsiesMohs micrographic surgeryRare adnexal tumorTreatment guidelinesCase reportDiagnostic challengeMicrographic surgeryBiologic behaviorComplete excisionAdnexal tumorsImmunohistochemical approachBiopsyCarcinomaRare variantsTumorsDiagnostic purposesPatientsSurgeryNeoplasmsExcisionCancer
2009
Gadolinium‐containing magnetic resonance image contrast agent promotes fibrocyte differentiation
Vakil V, Sung JJ, Piecychna M, Crawford JR, Kuo P, Abu‐Alfa A, Cowper SE, Bucala R, Gomer RH. Gadolinium‐containing magnetic resonance image contrast agent promotes fibrocyte differentiation. Journal Of Magnetic Resonance Imaging 2009, 30: 1284-1288. PMID: 19937928, PMCID: PMC2787835, DOI: 10.1002/jmri.21800.Peer-Reviewed Original ResearchConceptsPeripheral blood mononuclear cellsNephrogenic systemic fibrosisSerum amyloid PFibrocyte differentiationDifferentiation of monocytesNSF patientsBlood mononuclear cellsHemodialysis patientsInterleukin-12Mononuclear cellsPurified monocytesFibroblast-like cellsFibrotic lesionsHealthy controlsSystemic fibrosisAmyloid PContrast agentsPatientsMonocytesDifferentiation inhibitorWiley-LissFibrocytesOmniscanDifferentiation protocolsCellsFibrosis of the Hand Secondary to Jet Propellant Exposure: A New Clinical Syndrome
Spock CR, Masood Q, Cowper SE, Narayan D. Fibrosis of the Hand Secondary to Jet Propellant Exposure: A New Clinical Syndrome. Plastic & Reconstructive Surgery 2009, 124: 266e-267e. PMID: 20009810, DOI: 10.1097/prs.0b013e3181b98e91.Peer-Reviewed Case Reports and Technical Notes
2007
Metastatic cutaneous carcinoid tumor mimicking an adnexal poroid neoplasm
Puri PK, Galan A, Glusac EJ, Cowper SE. Metastatic cutaneous carcinoid tumor mimicking an adnexal poroid neoplasm. Journal Of Cutaneous Pathology 2007, 35: 54-57. PMID: 18095995, DOI: 10.1111/j.1600-0560.2007.00755.x.Peer-Reviewed Case Reports and Technical NotesConceptsMetastatic carcinoid tumorsCarcinoid tumorsPoroid neoplasmsCutaneous neoplasmsPigmented basal cell carcinomaPrimary cutaneous neoplasmAdditional clinical informationBasal cell carcinomaMetastatic carcinomaCell carcinomaComplete excisionShave biopsyImmunohistochemical stainsClinical informationUnusual caseApocrine poromaNeoplasmsTumorsMale menCarcinomaFirst caseBiopsyPoromaExcisionDiagnosisNephrogenic systemic fibrosis: a case series suggesting gadolinium as a possible aetiological factor
Moreno‐Romero J, Segura S, Mascaró JM, Cowper SE, Julià M, Poch E, Botey A, Herrero C. Nephrogenic systemic fibrosis: a case series suggesting gadolinium as a possible aetiological factor. British Journal Of Dermatology 2007, 157: 783-787. PMID: 17627792, DOI: 10.1111/j.1365-2133.2007.08067.x.Peer-Reviewed Original ResearchConceptsNephrogenic systemic fibrosisDevelopment of NSFRenal insufficiency patientsOnset of symptomsNephrogenic fibrosing dermopathyPossible aetiological factorsMagnetic resonance angiographyRenal diseaseCase seriesAetiological factorsSystemic fibrosisResonance angiographyFibrotic conditionsPatientsParamagnetic contrast agentHistory of useDiseaseContrast agentsAngiographyFibrosisDermopathyEtiologyGadoliniumSymptomsNephrogenic Systemic Fibrosis: A Population Study Examining the Relationship of Disease Development to Gadolinium Exposure
Deo A, Fogel M, Cowper SE. Nephrogenic Systemic Fibrosis: A Population Study Examining the Relationship of Disease Development to Gadolinium Exposure. Clinical Journal Of The American Society Of Nephrology 2007, 2: 264-267. PMID: 17699423, DOI: 10.2215/cjn.03921106.Peer-Reviewed Original ResearchConceptsNephrogenic systemic fibrosisGadolinium-containing contrast agentsGadolinium exposureIncidence of NSFSevere renal failurePopulation of patientsMajor risk factorOccurrence of NSFDevastating complicationESRD populationRenal failureSignificant morbidityRadiologic studiesRisk factorsSystemic fibrosisPopulation studiesESRDPatientsDisease developmentRecent reportsExposureContrast agentsRiskMorbidityComplicationsGadolinium is quantifiable within the tissue of patients with nephrogenic systemic fibrosis
High WA, Ayers RA, Cowper SE. Gadolinium is quantifiable within the tissue of patients with nephrogenic systemic fibrosis. Journal Of The American Academy Of Dermatology 2007, 56: 710-712. PMID: 17289213, DOI: 10.1016/j.jaad.2007.01.022.Peer-Reviewed Original Research
2005
Cellular digital fibromas: distinctive CD34‐positive lesions that may mimic dermatofibrosarcoma protuberans
McNiff JM, Subtil A, Cowper SE, Lazova R, Glusac EJ. Cellular digital fibromas: distinctive CD34‐positive lesions that may mimic dermatofibrosarcoma protuberans. Journal Of Cutaneous Pathology 2005, 32: 413-418. PMID: 15953374, DOI: 10.1111/j.0303-6987.2005.00358.x.Peer-Reviewed Original Research