2013
Evolution of the human gastrokine locus and confounding factors regarding the pseudogenicity of GKN3
Geahlen JH, Lapid C, Thorell K, Nikolskiy I, Huh WJ, Oates EL, Lennerz JK, Tian X, Weis VG, Khurana SS, Lundin SB, Templeton AR, Mills JC. Evolution of the human gastrokine locus and confounding factors regarding the pseudogenicity of GKN3. Physiological Genomics 2013, 45: 667-683. PMID: 23715263, PMCID: PMC3742967, DOI: 10.1152/physiolgenomics.00169.2012.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCarrier ProteinsComputational BiologyDNA PrimersEvolution, MolecularFluorescent Antibody TechniqueGastric MucosaGenetic LociGenetics, PopulationGenotypeHaplotypesHumansLikelihood FunctionsMacaca mulattaMembrane ProteinsMiceMice, Inbred C57BLMicroarray AnalysisMicroscopy, ConfocalModels, GeneticMutationPhylogenyPolymorphism, Single NucleotidePseudogenesRacial GroupsSelection, GeneticSpecies SpecificitySus scrofaConceptsSelective sweepsHuman genetic locusGenome evolutionGenomic neighborsSplice donor siteDirectional selectionHuman genomeGenetic lociBp downstreamEuropean genesGKN3Gastric mucous neck cellsStop codon mutationThird memberHuman populationGenesCodon mutationLociGKN2Haplotype analysisMucous neck cellsMutationsAfrican populationsNeck cellsGKN1
2011
Tamoxifen Induces Rapid, Reversible Atrophy, and Metaplasia in Mouse Stomach
Huh WJ, Khurana SS, Geahlen JH, Kohli K, Waller RA, Mills JC. Tamoxifen Induces Rapid, Reversible Atrophy, and Metaplasia in Mouse Stomach. Gastroenterology 2011, 142: 21-24.e7. PMID: 22001866, PMCID: PMC3708546, DOI: 10.1053/j.gastro.2011.09.050.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, OralAnimalsAtrophyChief Cells, GastricFemaleGene Expression RegulationInjections, IntraperitonealIntegrasesLac OperonMaleMetaplasiaMiceMice, Inbred BALB CMice, Inbred C57BLMice, TransgenicParietal Cells, GastricSelective Estrogen Receptor ModulatorsSpecies SpecificityTamoxifenTime FactorsConceptsSelective estrogen receptor modulatorsParietal cellsBody weight doseEstrogen receptor modulatorsTamoxifen side effectsAcid secretion inhibitionZymogenic chief cellsReversible atrophyWeight doseGastric toxicityIntraperitoneal administrationReceptor modulatorsNormal miceSide effectsSecretion inhibitionGastric parietal cellsChief cellsMouse stomachTamoxifenMetaplasiaMultiple strainsToxicityCellsPatientsAtrophy