The following is a comprehensive list of Yale Urology faculty’s contributions to the field, as represented in their published work/research for the 2nd quarter of this year. The listing is in ascending published date order and includes cite details and at least portions of each abstract/summary.
- Harold JA, Casilla-Lennon M, Kenney PA, Ratner ES. Vesical clear cell adenocarcinoma of Müllerian origin treated conservatively with partial cystectomy. BMJ Case Rep. 2022 Apr 5;15(4):e245015. doi: 10.1136/bcr-2021-245015. PMID: 35383096; PMCID: PMC8984011.
A 71-year-old woman presented with an intravesical bladder mass found to be a clear cell adenocarcinoma of Müllerian origin with positive PAX-8 staining after transurethral resection. Partial cystectomy along with total hysterectomy were performed, and final pathology revealed no residual tumour and extensive endometriosis. She declined adjuvant therapy and was dispositioned to surveillance.
- van der Heijden MS, Powles T, Petrylak D, de Wit R, Necchi A, Sternberg CN, Matsubara N, Nishiyama H, Castellano D, Hussain SA, Bamias A, Gakis G, Lee JL, Tagawa ST, Vaishampayan U, Aragon-Ching JB, Eigl BJ, Hozak RR, Rasmussen ER, Xia MS, Rhodes R, Wijayawardana S, Bell-McGuinn KM, Aggarwal A, Drakaki A. Predictive biomarkers for survival benefit with ramucirumab in urothelial cancer in the RANGE trial. Nat Commun. 2022 Apr 6;13(1):1878. doi: 10.1038/s41467-022-29441-y. PMID: 35388003; PMCID: PMC8987042.
The RANGE study (NCT02426125) evaluated ramucirumab (an anti-VEGFR2 monoclonal antibody) in patients with platinum-refractory advanced urothelial carcinoma (UC). Here, we use programmed cell death-ligand 1 (PD-L1) immunohistochemistry (IHC) and transcriptome analysis to evaluate the association of immune and angiogenesis pathways, and molecular subtypes, with overall survival (OS) in UC.
- Gardezi M, Choksi AU, Lokeshwar SD, Syed J, Honig SC. Distal erosion of an inflatable penile prosthetic as a complication of prone positioning in a COVID-19 respiratory supported patient. Int J Impot Res. 2022 Apr 7:1–2. doi: 10.1038/s41443-022-00571-7. Epub ahead of print. PMID: 35393534; PMCID: PMC8989101.
The literature regarding urologic complications from prolonged prone positioning in patients with COVID-19 ARDS is currently limited to a single case report describing Fournier’s gangrene in a proned patient with ARDS [5]. We describe the first reported instance of a patient with COVID-19 ARDS who developed penile glans necrosis and erosion of an inflatable penile prosthetic cylinder secondary to prolonged prone positioning.
- Masoom SN, Sundaram KM, Ghanouni P, Fütterer J, Oto A, Ayyagari R, Sprenkle P, Weinreb J, Arora S. Real-Time MRI-Guided Prostate Interventions. Cancers (Basel). 2022 Apr 7;14(8):1860. doi: 10.3390/cancers14081860. PMID: 35454773; PMCID: PMC9030365.
Prostate cancer (PCa) is the second most common cause of cancer death in males. Targeting MRI-visible lesions has led to an overall increase in the detection of clinically significant PCa compared to the prior practice of random ultrasound-guided biopsy of the prostate. Additionally, advances in MRI-guided minimally invasive focal treatments are providing new options for patients with PCa. This review summarizes the currently utilized real-time MRI-guided interventions for PCa diagnosis and treatment.
- Rickey, L. & Camenga, Deepa & Brady, S. & Williams, B. & Wyman, J. & Brault, Marie & Smith, A. & LaCoursiere, D. & James, A. & Lavender, M. & Low, Lisa. (2022). Women’s Knowledge of Bladder Health: What We Have Learned in the Prevention of Lower Urinary Tract Symptoms (PLUS) Research Consortium. Current Bladder Dysfunction Reports. 1-8. 10.1007/s11884-022-00655-6.
The goal of this manuscript is to review the current literature on bladder health education, summarize Prevention of Lower Urinary Tract Symptoms (PLUS) findings on environmental factors that influence knowledge and beliefs about toileting and bladder function, and describe how PLUS work will contribute to improved understanding of women’s bladder-related knowledge and inform prevention intervention strategies.
- Powles T, Park SH, Voog E, Caserta C, Valderrama BP, Gurney H, Kalofonos H, Radulovic S, Demey W, Ullén A, Loriot Y, Sridhar SS, Tsuchiya N, Kopyltsov E, Sternberg CN, Bellmunt J, Aragon-Ching JB, Petrylak DP, Laliberte RJ, Huang B, Costa N, Blake-Haskins JA, Grivas P. Plain language summary of results from the JAVELIN Bladder 100 study: avelumab maintenance treatment for advanced urothelial cancer. Future Oncol. 2022 Jun;18(19):2361-2371. doi: 10.2217/fon-2021-1631. Epub 2022 Apr 13. PMID: 35416053.
Researchers found that people treated with avelumab maintenance treatment plus best supportive care lived, on average, 7 months longer than people who received best supportive care alone. People treated with avelumab had more side effects than those not treated with avelumab, but most were not severe. Common side effects with avelumab included persistent tiredness, itchy skin, urinary tract infection, and diarrhea.
- Kong J, Lichtbroun B, Sterling J, Wang Y, Wang Q, Singer EA, Jang TL, Ghodoussipour S, Kim IY. Comparison of perioperative complications for extended vs standard pelvic lymph node dissection in patients undergoing radical prostatectomy for prostate cancer: a meta-analysis. Am J Clin Exp Urol. 2022 Apr 15;10(2):73-81. PMID: 35528467; PMCID: PMC9077149.
Conclusion: ePLND is associated with a significantly greater risk of perioperative complication compared to sPLND, but not when comparing these templates performed via a robotic approach. Additional studies comparing the complication rates of sPLND and ePLND when utilizing a robotic approach should be conducted.
- Petukhova-Greenstein A, Zeevi T, Yang J, Chai N, DiDomenico P, Deng Y, Ciarleglio M, Haider SP, Onyiuke I, Malpani R, Lin M, Kucukkaya AS, Gottwald LA, Gebauer B, Revzin M, Onofrey J, Staib L, Gunabushanam G, Taddei T, Chapiro J. MR Imaging Biomarkers for the Prediction of Outcome after Radiofrequency Ablation of Hepatocellular Carcinoma: Qualitative and Quantitative Assessments of the Liver Imaging Reporting and Data System and Radiomic Features. J Vasc Interv Radiol. 2022 Jul;33(7):814-824.e3. doi: 10.1016/j.jvir.2022.04.006. Epub 2022 Apr 20. PMID: 35460887; PMCID: PMC9335926.
Conclusions: Although multifocal HCC clearly indicates a more aggressive phenotype even in early-stage disease, the continuity of an enhancing capsule and a higher radiomic signature may add value as MR imaging biomarkers for poor PFS in HCC treated with RF ablation.
- Rajwa P, Pradere B, Gandaglia G, van den Bergh RCN, Tsaur I, Shim SR, Yanagisawa T, Laukhtina E, Mori K, Mostafaei H, Quhal F, Bryniarski P, Compérat E, Roubaud G, Massard C, Merseburger AS, Leapman MS, Spratt DE, Saad F, Joniau S, D'Amico AV, Briganti A, Shariat SF, Ploussard G; European Association of Urology Young Academic Urologists Prostate Cancer Working Party. Intensification of Systemic Therapy in Addition to Definitive Local Treatment in Nonmetastatic Unfavourable Prostate Cancer: A Systematic Review and Meta-analysis. Eur Urol. 2022 Jul;82(1):82-96. doi: 10.1016/j.eururo.2022.03.031. Epub 2022 Apr 22. PMID: 35465985.
Patient Summary: Our findings highlight that selected patients with high-risk nonmetastatic prostate cancer benefit from intensification of systemic therapy beyond hormonal treatment.
- Spees LP, Dinan MA, Jackson BE, Baggett CD, Wilson LE, Greiner MA, Kaye DR, Zhang T, George DJ, Scales CD, Pritchard JE, Leapman M, Gross CP, Wheeler SB. Patient- And Provider-Level Predictors of Survival Among Patients With Metastatic Renal Cell Carcinoma Initiating Oral Anticancer Agents. Clin Genitourin Cancer. 2022 Apr 25:S1558-7673(22)00084-2. doi: 10.1016/j.clgc.2022.04.010. Epub ahead of print. PMID: 35595633.
Purpose: In an era of rapid expansion of FDA approvals for oral anticancer agents (OAAs), it is important to understand the factors associated with survival among real-world populations, which include groups not well-represented in pivotal clinical trials of OAAs, such as the elderly, racial minorities, and medically complex patients. Our objective was to evaluate patient- and provider-level characteristics' associations with mortality among a multi-payer cohort of metastatic renal cell carcinoma (mRCC) patients who initiated OAAs.
- Boroda J, Zelkovic, P, Fang A, Gitlin, J, Franco I. Flow rates and flow indexes in pediatric patients after hypospadias urethroplasty: uroflow parameters in 458 repaired hypospadiac and 1,081 normal flows. Journal of Urology. 2022 May; 207(5S). doi: 10.1097/ju.0000000000002530.03.
Uroflowmetry is a noninvasive method used to assess for possible obstruction after hypospadias surgery. While numerous publications on this topic are available, few compare flows to age matched normals or to pediatric nomograms and most have small numbers of cases. Our aim is to establish normal flow values in patients after repair of varying degrees of hypospadias and to identify if there are reliable differences between those with complications and those without.
- Nair H, Montgomery T, Siev M, Murphy E, Simmons K, Motamedinia P, Dahl N, Singh D. Examining risks of composition conversion in recurrent stone formers. Journal of Urology. 2022 May;207(5S). doi:10.1097/JU.0000000000002621.06.
Most kidney stones are composed of calcium oxalate (CO), calcium phosphate (CP), uric acid (UA), or a mix. Age, gender, and urine pH are known to be associated with stone type, but factors related to conversion of one stone type to another have not been established. We examined the association between demographics and medical history of recurrent stone formers (RSFs) with conversion between CO, CP, and UA compositions.
- Grivas, Petros & Bellmunt, Joaquim & Park, Se Hoon & Voog, Eric & Caserta, Claudia & Pérez-Valderrama, Begoña & Gurney, Howard & Loriot, Yohann & Sridhar, Srikala & Tsuchiya, Norihiko & Sternberg, Cora & Aragon-Ching, Jeanny & Petrylak, Daniel & Blake-Haskins, John & Laliberte, Robert & Wang, Jing & Costa, Nuno & Powles, Thomas. (2022). Avelumab first-line maintenance for advanced urothelial carcinoma: long-term follow-up results from the javelin bladder 100 trial. Journal of Urology. 207. 10.1097/JU.0000000000002536.02.
Conclusions: Long-term follow-up from the JAVELIN Bladder 100 trial continues to show prolonged OS with avelumab+BSC vs BSC alone. These results further support the standard-of-care role for avelumab as 1L maintenance in pts with advanced UC that has not progressed with 1L platinum-containing chemotherapy.
- Armstrong AJ, Azad AA, Iguchi T, Szmulewitz RZ, Petrylak DP, Holzbeierlein J, Villers A, Alcaraz A, Alekseev B, Shore ND, Gomez-Veiga F, Rosbrook B, Zohren F, Yamada S, Haas GP, Stenzl A. Improved Survival With Enzalutamide in Patients With Metastatic Hormone-Sensitive Prostate Cancer. J Clin Oncol. 2022 May 20;40(15):1616-1622. doi: 10.1200/JCO.22.00193. Epub 2022 Apr 14. PMID: 35420921; PMCID: PMC9113211.
In primary analysis, enzalutamide plus androgen deprivation therapy (ADT) improved radiographic progression-free survival (rPFS) in patients with metastatic hormone-sensitive prostate cancer (mHSPC); however, overall survival data were immature. In the phase III, double-blind, global ARCHES trial (ClinicalTrials.gov identifier: NCT02677896), 1,150 patients with mHSPC were randomly assigned 1:1 to enzalutamide (160 mg once daily) plus ADT or placebo plus ADT, stratified by disease volume and prior docetaxel use.
- Fang A, Shumaker L, Martin K, Onah O, Jackson J, Khajir G, Gan R, Soodana-Prakash N, Patel H, Vourganti S, Filson C, Sprenkle P, Sonn G, Punnen S, Gupta G, Rais-Bahrami S. Multi-institutional analysis of clinical and imaging risk factors for detecting clinically significant prostate cancer in men with pi-rads 3 lesions. J. Urol. 2022 May 1;207(5S). doi: 10.1097/ju.0000000000002637.01.
While, it is standard to biopsy Prostate Imaging Reporting and Data System (PIRADS) 3 lesions, most do not contain clinically significant prostate cancer (CSPCa, Grade Group ≥2). We aim to identify clinical and magnetic resonance imaging (MRI) risk factors that predict CSPCa in men with PIRADS 3 lesions.
- Leapman M, Long J, Wang R, Sprenkle P, Ma X, Gross C. Four kallikrein panel testing among medicare beneficiaries undergoing prostate cancer screening. J. Urol. 2022 May 1;207(5S). doi: 10.1097/ju.0000000000002628.11.
Prostate-specific antigen (PSA) isoforms, including a panel of four kallikrein markers, improve the prediction of high-grade prostate cancer in clinical studies and may potentially mitigate biopsy after prostate cancer screening. We evaluated determinants of real-world use of a commercially available four kallikrein marker panel (4Kscore®), and subsequent use of prostate biopsy among tested patients.
- Khajir G, Kumar D, Rahman S, Leapman M, Levi A, Humphrey P, Sprenkle P. Discriminative significance of prostate biopsy decipher score to predict adverse pathology and pathological discordance at radical prostatectomy. J. Urol. 2022 May 1; 207(5S). doi: 10.1097/ju.0000000000002611.09.
The predictive value of Decipher test in Grade Group (GG) 3-5, pT3b-T4, or lymph node involvement at radical prostatectomy (RP) is well established. However, little is known about its prognostic significance in other pathological surrogates for metastatic potential, including extraprostatic extension (EPE) and surgical margin, as well as pathologic concordance between biopsy and RP. Therefore, we sought to determine if Decipher score was associated with the presence of those pathological features at RP and biopsy-RP pathological discordance.
- Khajir G, Press B, Sprenkle P, Washington S, Cooperberg M, Leapman M. Distribution of national comprehensive cancer network risk classifications using magnetic resonance imaging-ultrasound fusion versus systemic 12 core biopsies. J. Urol. 2022 May 1; 207(5S). doi: 10.1097/ju.0000000000002602.04.
A very small proportion of patients undergoing MRI-ultrasound fusion biopsy will be classified as “very-low risk” by the NCCN definition, and the majority of patients managed appropriately with active surveillance do not meet these criteria. These findings imply a need to broaden support for active surveillance outside of “very-low risk” criteria to promote greater uptake.
- Rahman, Syed & Syed, Jamil & Lokeshwar, Soum & Press, Benjamin & Monaghan, Thomas & Leapman, Michael. (2022). Overall survival among elderly patients with localized upper tract urothelial carcinoma receiving observation versus definitive treatment. Journal of Urology. 207. 10.1097/JU.0000000000002600.14.
Treatment decisions regarding elderly patients with upper tract urothelial carcinoma (UTUC) can be challenging given competing risks associated with age and comorbidities. Herein we assess survival outcomes among patients 80+ years diagnosed with clinically localized UTUC managed with definitive surgery versus expectant management.
- Leapman M, Thiel C, Gordon I, Nolte A, Perecman A, Overcash M, Sherman J. Environmental impact of transrectal ultrasound guided prostate biopsy. Journal of Urology. 207. 10.1097/ju.0000000000002573.14.
Healthcare is a major contributor to global pollution. Reducing the over-use of clinical care is one solution to lowering environmental emissions and improving care value. We aimed to estimate the environmental impact of transrectal ultrasound (TRUS) prostate biopsy, a procedure that is commonly performed in excess of recommended guidelines based on patient age or life-expectancy.
- Leapman MS, Dinan M, Pasha S, Long J, Washington SL 3rd, Ma X, Gross CP. Mediators of Racial Disparity in the Use of Prostate Magnetic Resonance Imaging Among Patients With Prostate Cancer. JAMA Oncol. 2022 May 1;8(5):687-696. doi: 10.1001/jamaoncol.2021.8116. PMID: 35238879; PMCID: PMC8895315.
Importance: Racial disparity in the use of prostate magnetic resonance imaging (MRI) presents obstacles to closing gaps in prostate cancer diagnosis, treatment, and outcome. Objective: To identify clinical, sociodemographic, and structural processes underlying racial disparity in the use of prostate MRI among men with a new diagnosis of prostate cancer.
- Lee G, Lee E, Leopold Z, Kim S, Leapman MS, Kim IY. Association between adverse surgical pathology and overall survival among patients with low-risk prostate cancer. Journal of Urology. 207. 10.1097/ju.0000000000002518.07.
The possibility of adverse surgical pathology among patients with low-risk prostate cancer is often used as a surrogate to determine the suitability of active surveillance (AS) versus definitive local treatment. We aimed to understand the association between adverse pathology and overall survival (OS) among ostensible candidates for AS who were treated with radical prostatectomy.
- Vemulakonda VM, Janzen N, Hittelman AB, Deakyne Davies S, Sevick C, Richardson AC, Schissel J, Dash D, Hintz R, Grider R, Adams P, Buck M, King J, Ewing E, Beltran G, Corbett S, Chiang G. Feasibility of establishing a multi-center research database using the electronic health record: The PURSUIT network. J Pediatr Urol. 2022 May 13:S1477-5131(22)00197-8. doi: 10.1016/j.jpurol.2022.05.004. Epub ahead of print. PMID: 35644792.
Discussion: This is the first study in urology to demonstrate that use of structured data elements can support multi-center research. Limitations include: inclusion of only academic sites with the Epic EHR and lack of data on utilization and sustainability at sites without a prior history of structured template use. Conclusions: Multi-center research collaboration using EHR-based data collection tools is feasible with generally high accuracy compared to manual chart review. Additionally, sites with a long history of template adoption have high levels of provider utilization.
- Nie J, Breyer BN, Leapman MS. AUTHOR REPLY. Urology. 2022 Jun;164:117. doi: 10.1016/j.urology.2022.01.060. PMID: 35710166.
… We would like to emphasize that the findings in the present study do not imply that private equity acquisition has led to lower access for patients with Medicaid. A more plausible explanation is that private equity firms target higher revenue practices which also have more restrictive Medicaid policies. Our work also highlights the challenges that still exist in increasing healthcare access for the large number of Americans who are now insured through Medicaid.
- Sadeghi S, Plets M, Lara PLN, Tangen C, Bangs R, Lerner SP, Flaig TW, Petrylak DP, Thompson I. A phase III randomized trial of eribulin (E) with or without gemcitabine versus standard of care (SOC) for metastic urothelial carcinoma (UC) refractory to or ineligible for PD/PDL1 antibody (Ab) [abstract]. In: 2022 ASCO Annual Meeting; 2022 Jun 3-7; Chicago, IL.
A phase I/II CTEP study of eribulin (E) for metastic UC (mUC) established the activity of E in UC with objective response rate (ORR) of 37.5% and a median progression free survival (PFS) of 4.1 months (mo) and median overall survival (OS) of 9.5 mo (N = 150). A phase II CTEP study of gemcitabine-eribulin (GE) in cisplatin ineligible mUC showed an ORR of 50%, median OS of 11.9 mo and median PFS of 5.3 mo (N = 24).
- Petrylak DP, Flaig TW, Mar N, Gourdin TS, Srinivas S, Rosenberg JE, Guseva M, Yu Y, Narayanan S, Hoimes CJ. Study EV-103 Cohort H: Antitumor activity of neoadjuvant treatment with enfortumab vedotin monotherapy in patients with muscle-invasive bladder cancer who are cisplatin-ineligible [abstract]. In: 2022 ASCO Annual Meeting; 2022 Jun 3-7; Chicago, IL.
Neoadjuvant chemotherapy prior to radical cystectomy and pelvic lymph node dissection (RC+PLND) has been shown to prolong overall survival for patients who are cisplatin (cis) eligible. The standard of care for cis-ineligible pts undergoing surgery does not include neoadjuvant therapy. Therefore, safe and effective neoadjuvant therapies are an unmet need for cis-ineligible pts with muscle invasive bladder cancer (MIBC). Enfortumab vedotin (EV) is an antibody-drug conjugate directed to Nectin-4, which is highly expressed in urothelial cancer, and has been shown to benefit previously treated locally advanced or metastatic urothelial cancer pts in phase 2 and 3 trials, including cis-ineligible pts.
- Rosenberg JE, Powles T, Sonpavde GP, Loriot Y, Duran I, Lee J-L, Matsubara N, Vulsteke C, Castellano DE, Mamtani R, Wu C, Matsangou M, Campbell MS, Petrylak DP. Long-term outcomes in EV-301: 24-month findings from the phase 3 trial of enfortumab vedotin versus chemotherapy in patients with previously treated advanced urothelial carcinoma [abstract]. In: 2022 ASCO Annual Meeting; 2022 Jun 3-7; Chicago, IL.
Background: Enfortumab vedotin (EV), an antibody-drug conjugate directed against Nectin-4, demonstrated longer overall survival (OS) and progression-free survival (PFS) in the confirmatory phase 3, randomized, open-label EV-301 trial at the prespecified interim analysis. The longer-term clinical profile of EV is unknown. Data from 12 additional months of follow-up in EV-301 are presented.
- Lu Y-T, Plets M, Morrison G, Cunha AT, Cen SY, Rhie SK, Siegmund K, Daneshmand S, Quinn Di, Meeks JJ, Lerner SP, Petrylak DP, McConkey DJ, Flaig TW, Thompson IM, Godkorn A. Cell-free DNA methylation as a predictive biomarker of response to neoadjuvant chemotherapy for patients with muscle-invasive bladder cancer [abstract]. In: 2022 ASCO Annual Meeting; 2022 Jun 3-7; Chicago, IL.
Background: Neoadjuvant chemotherapy is the standard of care in muscle-invasive bladder cancer patients. However, treatment is intense, the overall benefit is small, and there is no established marker to identify patients who benefit most. The aim of the study is to characterize cell-free DNA (cfDNA) methylation from patients receiving neoadjuvant chemotherapy in SWOG S1314, a prospective cooperative group trial, and to correlate the methylation signatures with pathologic response.
- Dizon DS, Szczepanek CM, Petrylak DP, Sparks DB, Tangen C, Lara PLN, Thompson IM, Blanke CD. National impact of the COVID-19 pandemic on clinical trial staff attrition: Results of the SWOG Cancer Research Network Survey of Oncology Research Professionals [abstract]. In: 2022 ASCO Annual Meeting; 2022 Jun 3-7; Chicago, IL.
Background: Severe shortages in clinical trial staffing across the United States and internationally has been anecdotally noted, but data are lacking. To better assess the scope and impact of staffing shortages, SWOG conducted a Cooperative Group-wide survey of Oncology Research Professionals (ORP).
- Nie J, Hsiang W, Lokeshwar SD, McMahon G, Demkowicz PC, Kenney PA, Breyer BN, Leapman MS. Association Between Private Equity Acquisition of Urology Practices and Physician Medicare Payments. Urology. 2022 Jun 6. doi: 10.1016/j.urology.2022.03.045.
Given rapid changes within certain healthcare markets, we sought to understand whether PE acquisition of urology practices has been associated with increases in volume and change of focus towards higher revenue services in the Medicare population.
- Ghiraldi E, Nguyen J, Buck M, Nair H, Israel G, Singh D. Using Peritumor and Intratumor Vascularity on Preoperative Imaging to Predict Fuhrman Grade Histology of Renal Tumors. J Endourol. 2022 Jun 7. doi: 10.1089/end.2022.0069. Epub ahead of print. PMID: 35670255.
Objective: To investigate if peri-tumor and/or intra-tumor vasculature is associated with high grade tumor histology for renal cell carcinoma. Methods A retrospective review at a tertiary care facility was performed of patients who underwent radical nephrectomy or partial nephrectomy for a renal tumor between January 2015 to December 2020. Data of tumor characteristics was collected from final pathology reports. A single radiologist specializing in genitourinary imaging reviewed all pre-operative cross-sectional imaging for peri-tumor vessels and intra-tumor vessels. Single and multivariable logistic regression was utilized to identify variables associated with high grade tumor histology.
- Marks VA, Hsiang WR, Umer W, Haleem A, Kim D, Kunstman JW, Leapman MS, Schuster KM. Access to telehealth services for colorectal cancer patients in the United States during the COVID-19 pandemic. Am J Surg. 2022 Jun 8:S0002-9610(22)00399-3. doi: 10.1016/j.amjsurg.2022.06.005. Epub ahead of print. PMID: 35701240; PMCID: PMC9176198.
Conclusions: We identified access disparities and predictive factors for telehealth availability for colorectal cancer care during the COVID-19 pandemic. These factors should be considered when constructing telehealth policies.
- Choksi AU, Khan AI, Lokeshwar SD, Segal D, Weiss RM, Martin DT. Functionalized nanoparticles targeting biomarkers for prostate cancer imaging and therapy. Am J Clin Exp Urol. 2022 Jun 15;10(3):142-153. PMID: 35874285; PMCID: PMC9301064.
The initial generation of nanoparticles relied on an enhanced permeability and retention effect, associated with an increased penetrability of tumor related blood vessels. With increasing knowledge of biomarkers and molecular targets, active targeting of circulating tumor cells by nanoparticles provides an exciting area for application. The selective targeting of prostate cancer cells using a nanotechnology-based mechanism has the potential to optimize the delivery of therapeutic payloads directly to prostate cancer cells while minimizing systemic toxicities … In this review, we present the molecular biomarkers that have been targeted by ligands conjugated to the surface of nanoparticles for prostate cancer imaging and therapy.
- Shore ND, Renzulli J, Fleshner NE, Hollowell CMP, Vourganti S, Silberstein J, Siddiqui R, Hairston J, Elsouda D, Russell D, Cooperberg MR, Tomlins SA. Enzalutamide Monotherapy vs Active Surveillance in Patients With Low-risk or Intermediate-risk Localized Prostate Cancer: The ENACT Randomized Clinical Trial. JAMA Oncol. 2022 Aug 1;8(8):1128-1136. doi: 10.1001/jamaoncol.2022.1641. Erratum in: JAMA Oncol. 2022 Aug 1;8(8):1225. PMID: 35708696; PMCID: PMC9204619.
Importance: There are few published studies prospectively assessing pharmacological interventions that may delay prostate cancer progression in patients undergoing active surveillance (AS). Objective: To compare the efficacy and safety of enzalutamide monotherapy plus AS vs AS alone in patients with low-risk or intermediate-risk prostate cancer.
- Hanchuk S, Casilla-Lennon M, Zheng S, Kim DD, Press B, Nguyen JV, Grimshaw A, Leapman MS, Rickey LM, Cavallo JA. The Medical Community's Evolving Focus on Physician and Surgeon Pregnancy: Thematic Trends From a Scoping Review. Acad Med. 2022 Jul 1;97(7):1071-1078. doi: 10.1097/ACM.0000000000004629. Epub 2022 Jun 23. PMID: 35171119; PMCID: PMC9247020.
Purpose: The authors aimed to chronicle the evolution of the medical community's study of physician and surgeon pregnancy by investigating thematic trends in the literature in the context of pertinent sociopolitical events.
- Kim IE Jr, Kim DD, Kim S, Ma S, Jang TL, Singer EA, Ghodoussipour S, Kim IY. Changes in prostate cancer survival among insured patients in relation to USPSTF screening recommendations. BMC Urol. 2022 Jun 25;22(1):91. doi: 10.1186/s12894-022-01045-0. PMID: 35752822; PMCID: PMC9233816.
Conclusions: Although the underlying reasons are not clear, the USPSTF's 2012 PSA screening recommendation may have hindered insured patients from being regularly screened for prostate cancer and selectively led to worse outcomes for insured patients without affecting the survival of uninsured patients.
- Laditi F, Nie J, Jones T, Leapman MS. Variation and Disparity in the Use of Prostate Cancer Risk Stratification Tools in the United States. European Urology Focus, 2022, ISSN 2405-4569. doi: 10.1016/j.euf.2022.06.003. (https://www.sciencedirect.com/science/article/pii/S2405456922001316).
In this review, we found that use of prostate magnetic resonance imaging (MRI) scans and genetic testing differed by region, and race, with less prostate MRI use among Black versus White patients. These findings can help raise awareness about gaps in access to new prostate cancer tools.
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