Cancer Signaling Networks Recent Publications
2024
- Rapid and sustained improvements in itch and quality of life with upadacitinib plus topical corticosteroids in adults and adolescents with atopic dermatitis: 52-week outcomes from the phase 3 AD Up study.Magnolo N, Cameron MC, Shahriari M, Geng B, Calimlim BM, Teixeira H, Hu X, Yang Y, Liu Y, Zhang S, Sancho Sanchez C, Altman K, Langley RG. J Dermatolog Treat. 2024 Dec; 2024 May 2. PMID: 38697950.
- The development of hair follicles and nail.Lee SH, Platt S, Lim CH, Ito M, Myung P. Dev Biol. 2024 Sep; 2024 May 15. PMID: 38759942.
- Deficits in brain glucose transport among younger adults with obesity.Gunawan F, Matson BC, Coppoli A, Jiang L, Ding Y, Perry R, Sanchez-Rangel E, DeAguiar RB, Behar KL, Rothman DL, Mason GF, Hwang JJ. Obesity (Silver Spring). 2024 Jul; 2024 May 19. PMID: 38764181.
- Mitofusin 2 plays a critical role in maintaining the functional integrity of the neuromuscular-skeletal axis.Zhu M, Zeiss C, Hamrick MW, Weinstein RS, Sun BH, Brotto M, Liu X, Siu E, Huttner A, Tommasini S, Simpson C, Insogna K. Bone. 2024 Jul; 2024 Mar 27. PMID: 38552893.
- TGF-β1 Drives Integrin-Dependent Pericyte Migration and Microvascular Destabilization in Fibrotic Disease.Pellowe AS, Wu MJ, Kang TY, Chung TD, Ledesma-Mendoza A, Herzog E, Levchenko A, Odell I, Varga J, Gonzalez AL. Am J Pathol. 2024 Jul; 2024 Mar 26. PMID: 38548268.
- Spatially resolved epigenome sequencing via Tn5 transposition and deterministic DNA barcoding in tissue.Farzad N, Enninful A, Bao S, Zhang D, Deng Y, Fan R. Nat Protoc. 2024 Jun 28; 2024 Jun 28. PMID: 38943021.
- Neutrophils insert elastase into hepatocytes to regulate calcium signaling in alcohol-associated hepatitis.Ogino N, Leite MF, Guerra MT, Kruglov E, Asashima H, Hafler DA, Ito T, Pereira JP, Peiffer BJ, Sun Z, Ehrlich BE, Nathanson MH. J Clin Invest. 2024 Jun 25; 2024 Jun 25. PMID: 38916955.
- Impact of Abl2/Arg deficiency on anxiety and depressive behaviors in mice.Yao X, Chen R, Chen H, Koleske A, Xiao X. Behav Brain Res. 2024 Jun 25; 2024 Apr 30. PMID: 38697301.
- Deciphering spatial domains from spatial multi-omics with SpatialGlue.Long Y, Ang KS, Sethi R, Liao S, Heng Y, van Olst L, Ye S, Zhong C, Xu H, Zhang D, Kwok I, Husna N, Jian M, Ng LG, Chen A, Gascoigne NRJ, Gate D, Fan R, Xu X, Chen J. Nat Methods. 2024 Jun 21; 2024 Jun 21. PMID: 38907114.
- Association of T-cell subtypes with macrophage-specific arterial infiltration in PWH.Schnittman SR, Talathi R, Wilks MQ, Hedgire S, Lu MT, Fourman LT, Alagpulinsa DA, Stockman SL, White KS, Wallis ZK, Autissier P, Stanley TL, Lee H, Honigberg MC, El-Fakhri G, Williams KC, Zanni MV, Grinspoon SK, Toribio M. AIDS. 2024 Jun 21; 2024 Jun 21. PMID: 38905489.
- Structural insights into the role and targeting of EGFRvIII.Bagchi A, Stayrook SE, Xenaki KT, Starbird CA, Doulkeridou S, El Khoulati R, Roovers RC, Schmitz KR, van Bergen En Henegouwen PMP, Ferguson KM. Structure. 2024 Jun 19; 2024 Jun 19. PMID: 38908376.
- Latrophilin-2 mediates fluid shear stress mechanotransduction at endothelial junctions.Tanaka K, Chen M, Prendergast A, Zhuang Z, Nasiri A, Joshi D, Hintzen J, Chung M, Kumar A, Mani A, Koleske A, Crawford J, Nicoli S, Schwartz MA. EMBO J. 2024 Jun 17; 2024 Jun 17. PMID: 38886581.
- Overexpression of Malat1 drives metastasis through inflammatory reprogramming of the tumor microenvironment.Martinez-Terroba E, Plasek-Hegde LM, Chiotakakos I, Li V, de Miguel FJ, Robles-Oteiza C, Tyagi A, Politi K, Zamudio JR, Dimitrova N. Sci Immunol. 2024 Jun 14; 2024 Jun 14. PMID: 38875320.
- Synergistic interaction between pay-it-forward incentives and recreational drug use on hepatitis B virus and hepatitis C virus testing among men who have sex with men in China.Ai W, Xie Y, Lu H, Ai T, Wu D, Zhang Y, Marley G, Ong J, Tucker JD, Tang W. Sex Transm Infect. 2024 Jun 11; 2024 Jun 11. PMID: 38862237.
- Heterogeneous gene expression during early arteriovenous fistula remodeling suggests that downregulation of metabolism predicts adaptive venous remodeling.Ohashi Y, Protack CD, Aoyagi Y, Gonzalez L, Thaxton C, Zhang W, Kano M, Bai H, Yatsula B, Alves R, Hoshina K, Schneider EB, Long X, Perry RJ, Dardik A. Sci Rep. 2024 Jun 10; 2024 Jun 10. PMID: 38858395.
- High-throughput transcriptome profiling indicates ribosomal RNAs to be associated with resistance to immunotherapy in non-small cell lung cancer (NSCLC).Moutafi MK, Bates KM, Aung TN, Milian RG, Xirou V, Vathiotis IA, Gavrielatou N, Angelakis A, Schalper KA, Salichos L, Rimm DL. J Immunother Cancer. 2024 Jun 10; 2024 Jun 10. PMID: 38857914.
- Modulation of FGF pathway signaling and vascular differentiation using designed oligomeric assemblies.Edman NI, Phal A, Redler RL, Schlichthaerle T, Srivatsan SR, Ehnes DD, Etemadi A, An SJ, Favor A, Li Z, Praetorius F, Gordon M, Vincent T, Marchiano S, Blakely L, Lin C, Yang W, Coventry B, Hicks DR, Cao L, Bethel N, Heine P, Murray A, Gerben S, Carter L, Miranda M, Negahdari B, Lee S, Trapnell C, Zheng Y, Murry CE, Schweppe DK, Freedman BS, Stewart L, Ekiert DC, Schlessinger J, Shendure J, Bhabha G, Ruohola-Baker H, Baker D. Cell. 2024 Jun 7; 2024 Jun 7. PMID: 38861993.
- Considerations for viral co-infection studies in human populations.Chin T, Foxman EF, Watkins TA, Lipsitch M. mBio. 2024 Jun 7; 2024 Jun 7. PMID: 38847531.
- A DNA-based molecular clamp for probing protein interactions and structure under force.Chung M, Zhou K, Powell J, Lin C, Schwartz MA. bioRxiv. 2024 Jun 6; 2024 Jun 6. PMID: 38895381.
- Spatially informed gene signatures for response to immunotherapy in melanoma.Aung TN, Warrell J, Martinez-Morilla S, Gavrielatou N, Vathiotis I, Yaghoobi V, Kluger HM, Gerstein M, Rimm DL. Clin Cancer Res. 2024 Jun 5; 2024 Jun 5. PMID: 38837895.
- Development of a Longitudinal Prostate Cancer Transcriptomic and Clinical Data Linkage.Leapman MS, Ho J, Liu Y, Filson CP, Zhao X, Hakansson A, Proudfoot JA, Davicioni E, Martin DT, An Y, Seibert TM, Lin DW, Spratt DE, Cooperberg MR, Ross AE, Sprenkle PC. JAMA Netw Open. 2024 Jun 3; 2024 Jun 3. PMID: 38874922.
- SenNet recommendations for detecting senescent cells in different tissues.Suryadevara V, Hudgins AD, Rajesh A, Pappalardo A, Karpova A, Dey AK, Hertzel A, Agudelo A, Rocha A, Soygur B, Schilling B, Carver CM, Aguayo-Mazzucato C, Baker DJ, Bernlohr DA, Jurk D, Mangarova DB, Quardokus EM, Enninga EAL, Schmidt EL, Chen F, Duncan FE, Cambuli F, Kaur G, Kuchel GA, Lee G, Daldrup-Link HE, Martini H, Phatnani H, Al-Naggar IM, Rahman I, Nie J, Passos JF, Silverstein JC, Campisi J, Wang J, Iwasaki K, Barbosa K, Metis K, Nernekli K, Niedernhofer LJ, Ding L, Wang L, Adams LC, Ruiyang L, Doolittle ML, Teneche MG, Schafer MJ, Xu M, Hajipour M, Boroumand M, Basisty N, Sloan N, Slavov N, Kuksenko O, Robson P, Gomez PT, Vasilikos P, Adams PD, Carapeto P, Zhu Q, Ramasamy R, Perez-Lorenzo R, Fan R, Dong R, Montgomery RR, Shaikh S, Vickovic S, Yin S, Kang S, Suvakov S, Khosla S, Garovic VD, Menon V, Xu Y, Song Y, Suh Y, Dou Z, Neretti N. Nat Rev Mol Cell Biol. 2024 Jun 3; 2024 Jun 3. PMID: 38831121.
- Development of (225)Ac-doped biocompatible nanoparticles for targeted alpha therapy.Toro-González M, Akingbesote N, Bible A, Pal D, Sanders B, Ivanov AS, Jansone-Popova S, Popovs I, Benny P, Perry R, Davern S. J Nanobiotechnology. 2024 Jun 2; 2024 Jun 2. PMID: 38825717.
- Glucose Regulation of β-Cell KATP Channels: It Is Time for a New Model!Merrins MJ, Kibbey RG. Diabetes. 2024 Jun 1. PMID: 38768366.
- Oncogenic Kras induces spatiotemporally specific tissue deformation through converting pulsatile into sustained ERK activation.Xin T, Gallini S, Wei H, Gonzalez DG, Matte-Martone C, Machida H, Fujiwara H, Pasolli HA, Suozzi KC, Gonzalez LE, Regot S, Greco V. Nat Cell Biol. 2024 Jun; 2024 Apr 30. PMID: 38689013.
- Presynaptic density determined by SV2A PET is closely associated with postsynaptic metabotropic glutamate receptor 5 availability and independent of amyloid pathology in early cognitive impairment.Wang J, Huang Q, He K, Li J, Guo T, Yang Y, Lin Z, Li S, Vanderlinden G, Huang Y, Van Laere K, Guan Y, Guo Q, Ni R, Li B, Xie F. Alzheimers Dement. 2024 Jun; 2024 Apr 18. PMID: 38634334.
- Providing 0.1 Full-Time Equivalent (FTE) Support to Fellowship Core Faculty Improves Faculty Involvement in Fellowship Education and Recruitment.Butt A, Christian J, Kress A, Lu BY, Hurwitz ME, Goldberg SB, Podoltsev NA, Gilkes L, Lee AI. J Cancer Educ. 2024 Jun; 2024 Mar 2. PMID: 38430454.
- Health-related Quality of Life in Patients with Previously Treated Advanced Urothelial Carcinoma from EV-301: A Phase 3 Trial of Enfortumab Vedotin Versus Chemotherapy.Rosenberg JE, Mamtani R, Sonpavde GP, Loriot Y, Duran I, Lee JL, Matsubara N, Vulsteke C, Castellano D, Sridhar SS, Pappot H, Gurney H, Bedke J, van der Heijden MS, Galli L, Keam B, Masumori N, Meran J, O'Donnell PH, Park SH, Grande E, Sengeløv L, Uemura H, Skaltsa K, Campbell M, Matsangou M, Wu C, Hepp Z, McKay C, Powles T, Petrylak DP. Eur Urol. 2024 Jun; 2024 Feb 28. PMID: 38418343.
- Author Correction: Epidemiology, treatment and outcomes of primary renal sarcomas in adult patients.Uhlig J, Uhlig A, Deshpande H, Ströbel P, Trojan L, Lotz J, Hurwitz M, Hafez O, Humphrey P, Grünwald V, Kim HS. Sci Rep. 2024 May 24; 2024 May 24. PMID: 38789511.
- The Evolution of Mouse Models of Cancer: Past, Present, and Future.Abate-Shen C, Politi K. Cold Spring Harb Perspect Med. 2024 May 21; 2024 May 21. PMID: 38772706.
- Viral Interference During Influenza A-SARS-CoV-2 Coinfection of the Human Airway Epithelium and Reversal by Oseltamivir.Cheemarla NR, Watkins TA, Mihaylova VT, Foxman EF. J Infect Dis. 2024 May 15. PMID: 37722683.
- Protein phosphatase 6 activates NF-κB to confer sensitivity to MAPK pathway inhibitors in KRAS- and BRAF-mutant cancer cells.Zhang H, Read A, Cataisson C, Yang HH, Lee WC, Turk BE, Yuspa SH, Luo J. Sci Signal. 2024 May 14; 2024 May 14. PMID: 38743809.
- In the Eyes of the Beholder-New Mertk Knockout Mouse and Re-Evaluation of Phagocytosis versus Anti-Inflammatory Functions of MERTK.Ghosh S, Finnemann SC, Vollrath D, Rothlin CV. Int J Mol Sci. 2024 May 13; 2024 May 13. PMID: 38791338.
- Network-based elucidation of colon cancer drug resistance mechanisms by phosphoproteomic time-series analysis.Rosenberger G, Li W, Turunen M, He J, Subramaniam PS, Pampou S, Griffin AT, Karan C, Kerwin P, Murray D, Honig B, Liu Y, Califano A. Nat Commun. 2024 May 9; 2024 May 9. PMID: 38724493.
- Fibroblast expression of transmembrane protein smoothened governs microenvironment characteristics after acute kidney injury.Gui Y, Fu H, Palanza Z, Tao J, Lin YH, Min W, Qiao Y, Bonin C, Hargis G, Wang Y, Yang P, Kreutzer DL, Wang Y, Liu Y, Yu Y, Liu Y, Zhou D. J Clin Invest. 2024 May 7; 2024 May 7. PMID: 38713523.
- Renalase Levels are Decreased in Maternal Blood and Placental Tissues in Pregnancies Associated with Preterm Preeclampsia.Soliman Y, Eke C, Guo X, Wang M, Silva T, Désir GV, Konnikova L. Res Sq. 2024 May 6; 2024 May 6. PMID: 38765989.
- BERNN: Enhancing classification of Liquid Chromatography Mass Spectrometry data with batch effect removal neural networks.Pelletier SJ, Leclercq M, Roux-Dalvai F, de Geus MB, Leslie S, Wang W, Lam TT, Nairn AC, Arnold SE, Carlyle BC, Precioso F, Droit A. Nat Commun. 2024 May 6; 2024 May 6. PMID: 38710683.
- Afadin-nectin forces its way to the front.Sebbagh M, Schwartz MA. J Cell Biol. 2024 May 6; 2024 Apr 2. PMID: 38563860.
- TREM2 function in glioblastoma immune microenvironment: Can we distinguish reality from illusion?Ghosh S, Rothlin CV. Neuro Oncol. 2024 May 3. PMID: 38290471.
- Epidemiology, treatment and outcomes of primary renal sarcomas in adult patients.Uhlig J, Uhlig A, Deshpande H, Ströbel P, Trojan L, Lotz J, Hurwitz M, Hafez O, Humphrey P, Grünwald V, Kim HS. Sci Rep. 2024 May 2; 2024 May 2. PMID: 38693188.
- The intrinsic substrate specificity of the human tyrosine kinome.Yaron-Barir TM, Joughin BA, Huntsman EM, Kerelsky A, Cizin DM, Cohen BM, Regev A, Song J, Vasan N, Lin TY, Orozco JM, Schoenherr C, Sagum C, Bedford MT, Wynn RM, Tso SC, Chuang DT, Li L, Li SS, Creixell P, Krismer K, Takegami M, Lee H, Zhang B, Lu J, Cossentino I, Landry SD, Uduman M, Blenis J, Elemento O, Frame MC, Hornbeck PV, Cantley LC, Turk BE, Yaffe MB, Johnson JL. Nature. 2024 May; 2024 May 8. PMID: 38720073.
- Finding Your CAR: The Road Ahead for Engineered T Cells.Chen PH, Raghunandan R, Morrow JS, Katz SG. Am J Pathol. 2024 May 1; 2024 May 1. PMID: 38697513.
- An algorithm for standardization of tumor Infiltrating lymphocyte evaluation in head and neck cancers.Xirou V, Moutafi M, Bai Y, Nwe Aung T, Burela S, Liu M, Kimple RJ, Shabbir Ahmed F, Schultz B, Flieder D, Connolly DC, Psyrri A, Burtness B, Rimm DL. Oral Oncol. 2024 May; 2024 Mar 27. PMID: 38547779.
- Early and Sustained Improvements in Symptoms and Quality of Life with Upadacitinib in Adults and Adolescents with Moderate-to-Severe Atopic Dermatitis: 52-Week Results from Two Phase III Randomized Clinical Trials (Measure Up 1 and Measure Up 2).Silverberg JI, Gooderham MJ, Paller AS, Deleuran M, Bunick CG, Gold LFS, Hijnen D, Calimlim BM, Lee WJ, Teixeira HD, Hu X, Zhang S, Yang Y, Grada A, Platt AM, Thaçi D. Am J Clin Dermatol. 2024 May; 2024 Mar 25. PMID: 38528257.
- Author Correction: Subclonal cooperation drives metastasis by modulating local and systemic immune microenvironments.Janiszewska M, Tabassum DP, Castaño Z, Cristea S, Yamamoto KN, Kingston NL, Murphy KC, Shu S, Harper NW, Del Alcazar CG, Alečković M, Ekram MB, Cohen O, Kwak M, Qin Y, Laszewski T, Luoma A, Marusyk A, Wucherpfennig KW, Wagle N, Fan R, Michor F, McAllister SS, Polyak K. Nat Cell Biol. 2024 May. PMID: 38443568.
- Clinical predictive value of renalase in post-ERCP pancreatitis.Muniraj T, Desir G, Gorelick FS, Guo X, Ciarleglio MM, Deng Y, Jamidar PA, Farrell J, Aslanian HR, Laine L. Gastrointest Endosc. 2024 May; 2023 Dec 14. PMID: 38103747.
- Integrated mutational landscape analysis of poorly differentiated high-grade neuroendocrine carcinoma of the uterine cervix.Bellone S, Jeong K, Halle MK, Krakstad C, McNamara B, Greenman M, Mutlu L, Demirkiran C, Hartwich TMP, Yang-Hartwich Y, Zipponi M, Buza N, Hui P, Raspagliesi F, Lopez S, Paolini B, Milione M, Perrone E, Scambia G, Altwerger G, Ravaggi A, Bignotti E, Huang GS, Andikyan V, Clark M, Ratner E, Azodi M, Schwartz PE, Quick CM, Angioli R, Terranova C, Zaidi S, Nandi S, Alexandrov LB, Siegel ER, Choi J, Schlessinger J, Santin AD. Proc Natl Acad Sci U S A. 2024 Apr 23; 2024 Apr 16. PMID: 38625939.
- Sacituzumab Govitecan in Combination With Pembrolizumab for Patients With Metastatic Urothelial Cancer That Progressed After Platinum-Based Chemotherapy: TROPHY-U-01 Cohort 3.Grivas P, Pouessel D, Park CH, Barthelemy P, Bupathi M, Petrylak DP, Agarwal N, Gupta S, Fléchon A, Ramamurthy C, Davis NB, Recio-Boiles A, Sternberg CN, Bhatia A, Pichardo C, Sierecki M, Tonelli J, Zhou H, Tagawa ST, Loriot Y. J Clin Oncol. 2024 Apr 20; 2024 Jan 23. PMID: 38261969.
- Patient-Reported Outcomes in Patients With Advanced Urothelial Cancer Who Are Ineligible for Cisplatin and Treated With First-Line Enfortumab Vedotin Alone or With Pembrolizumab.Milowsky MI, O'Donnell PH, Hoimes CJ, Petrylak DP, Flaig TW, Moon HH, Friedlander TW, Mar N, McKay RR, Srinivas S, Gravis G, Ramamurthy C, Bupathi M, Bracarda S, Wright P, Hepp Z, Carret AS, Yu Y, Dillon R, Kataria R, Beaumont JL, Purnajo I, Rosenberg JE. J Clin Oncol. 2024 Apr 20; 2024 Jan 12. PMID: 38215355.
- Focal adhesion-derived liquid-liquid phase separations regulate mRNA translation.Kumar A, Tanaka K, Schwartz MA. bioRxiv. 2024 Apr 18; 2024 Apr 18. PMID: 38045367.
- Metastasis of colon cancer requires Dickkopf-2 to generate cancer cells with Paneth cell properties.Shin JH, Park J, Lim J, Jeong J, Dinesh RK, Maher SE, Hong JY, Wysolmerski J, Choi J, Bothwell ALM. bioRxiv. 2024 Apr 15; 2024 Apr 15. PMID: 38659853.
- Reciprocal antagonism of PIN1-APC/C(CDH1) governs mitotic protein stability and cell cycle entry.Ke S, Dang F, Wang L, Chen JY, Naik MT, Li W, Thavamani A, Kim N, Naik NM, Sui H, Tang W, Qiu C, Koikawa K, Batalini F, Stern Gatof E, Isaza DA, Patel JM, Wang X, Clohessy JG, Heng YJ, Lahav G, Liu Y, Gray NS, Zhou XZ, Wei W, Wulf GM, Lu KP. Nat Commun. 2024 Apr 15; 2024 Apr 15. PMID: 38622115.
- ASCL1 Drives Tolerance to Osimertinib in EGFR Mutant Lung Cancer in Permissive Cellular Contexts.Hu B, Wiesehöfer M, de Miguel FJ, Liu Z, Chan LH, Choi J, Melnick MA, Arnal Estape A, Walther Z, Zhao D, Lopez-Giraldez F, Wurtz A, Cai G, Fan R, Gettinger S, Xiao A, Yan Q, Homer R, Nguyen DX, Politi K. Cancer Res. 2024 Apr 15. PMID: 38359163.
- Optimal conditions for carrying out trypsin digestions on complex proteomes: From bulk samples to single cells.Mansuri MS, Bathla S, Lam TT, Nairn AC, Williams KR. J Proteomics. 2024 Apr 15; 2024 Feb 5. PMID: 38325732.
- Treatment-free survival outcomes from the phase II study of nivolumab and salvage nivolumab/ipilimumab in advanced clear cell renal cell carcinoma (HCRN GU16-260-Cohort A).Atkins MB, Jegede OA, Haas NB, Mcdermott DF, Bilen MA, Stein M, Sosman J, Alter R, Plimack ER, Ornstein MC, Hurwitz M, Peace DJ, Einstein D, Catalano PJ, Hammers H, Regan MM. J Immunother Cancer. 2024 Apr 11; 2024 Apr 11. PMID: 38604810.
- Tau pathology is associated with synaptic density and longitudinal synaptic loss in Alzheimer's disease.Wang J, Huang Q, Chen X, You Z, He K, Guo Q, Huang Y, Yang Y, Lin Z, Guo T, Zhao J, Guan Y, Li B, Xie F. Mol Psychiatry. 2024 Apr 8; 2024 Apr 8. PMID: 38589563.
- Cognitive Bias in the Patient Encounter: Part II. Debiasing using an adaptive toolbox.Ko CJ, Gehlhausen JR, Cohen JM, Jiang Y, Myung P, Croskerry P. J Am Acad Dermatol. 2024 Apr 6; 2024 Apr 6. PMID: 38588820.
- CD70-Targeted Allogeneic CAR T-Cell Therapy for Advanced Clear Cell Renal Cell Carcinoma.Pal SK, Tran B, Haanen JBAG, Hurwitz ME, Sacher A, Tannir NM, Budde LE, Harrison SJ, Klobuch S, Patel SS, Meza L, Dequeant ML, Ma A, He QA, Williams LM, Keegan A, Gurary EB, Dar H, Karnik S, Guo C, Heath H, Yuen RR, Morrow PK, Agarwal N, Srour SA. Cancer Discov. 2024 Apr 5; 2024 Apr 5. PMID: 38583184.
- Gene trajectory inference for single-cell data by optimal transport metrics.Qu R, Cheng X, Sefik E, Stanley Iii JS, Landa B, Strino F, Platt S, Garritano J, Odell ID, Coifman R, Flavell RA, Myung P, Kluger Y. Nat Biotechnol. 2024 Apr 5; 2024 Apr 5. PMID: 38580861.
- Apoptotic cell identity induces distinct functional responses to IL-4 in efferocytic macrophages.Liebold I, Al Jawazneh A, Casar C, Lanzloth C, Leyk S, Hamley M, Wong MN, Kylies D, Gräfe SK, Edenhofer I, Aranda-Pardos I, Kriwet M, Haas H, Krause J, Hadjilaou A, Schromm AB, Richardt U, Eggert P, Tappe D, Weidemann SA, Ghosh S, Krebs CF, A-Gonzalez N, Worthmann A, Lohse AW, Huber S, Rothlin CV, Puelles VG, Jacobs T, Gagliani N, Bosurgi L. Science. 2024 Apr 5; 2024 Apr 5. PMID: 38574142.
- A disease-associated PPP2R3C-MAP3K1 phospho-regulatory module controls centrosome function.Ganga AK, Sweeney LK, Ramos AR, Bishop CS, Hamel V, Guichard P, Breslow DK. bioRxiv. 2024 Apr 3; 2024 Apr 3. PMID: 38617270.
- Expert Perspectives on Controversies in Metastatic Castration-Resistant Prostate Cancer Management: Narrative Review and Report of the First US Prostate Cancer Conference Part 2.Bryce AH, Crawford ED, Agarwal N, Hussain MH, Beltran H, Cooperberg MR, Petrylak DP, Shore N, Spratt DE, Tagawa ST, Antonarakis ES, Aparicio AM, Armstrong AJ, Boike TP, Calais J, Carducci MA, Chapin BF, Cookson MS, Davis JW, Dorff T, Eggener SE, Feng FY, Gleave M, Higano C, Iagaru A, Morgans AK, Morris M, Murray KS, Poage W, Rettig MB, Sartor O, Scher HI, Sieber P, Small E, Srinivas S, Yu EY, Zhang T, Koo PJ. JU Open Plus. 2024 Apr; 2024 Apr 15. PMID: 38774467.
- Expert Perspectives on Controversies in Castration-Sensitive Prostate Cancer Management: Narrative Review and Report of the First US Prostate Cancer Conference Part 1.Crawford ED, Bryce AH, Hussain MH, Agarwal N, Beltran H, Cooperberg MR, Petrylak DP, Shore N, Spratt DE, Tagawa ST, Antonarakis ES, Aparicio AM, Armstrong AJ, Boike TP, Calais J, Carducci MA, Chapin BF, Cookson MS, Davis JW, Dorff T, Eggener SE, Feng FY, Gleave M, Higano C, Iagaru A, Morgans AK, Morris M, Murray KS, Poage W, Rettig MB, Sartor O, Scher HI, Sieber P, Small E, Srinivas S, Yu EY, Zhang T, Koo PJ. JU Open Plus. 2024 Apr; 2024 Apr 15. PMID: 38774466.
- Area Vulnerability and Disparities in Therapy for Patients With Metastatic Renal Cell Carcinoma.Rahman SN, Long JB, Westvold SJ, Leapman MS, Spees LP, Hurwitz ME, McManus HD, Gross CP, Wheeler SB, Dinan MA. JAMA Netw Open. 2024 Apr 1; 2024 Apr 1. PMID: 38687479.
- Fatty acid binding protein 5 suppression attenuates obesity-induced hepatocellular carcinoma by promoting ferroptosis and intratumoral immune rewiring.Sun J, Esplugues E, Bort A, Cardelo MP, Ruz-Maldonado I, Fernández-Tussy P, Wong C, Wang H, Ojima I, Kaczocha M, Perry R, Suárez Y, Fernández-Hernando C. Nat Metab. 2024 Apr; 2024 Apr 25. PMID: 38664583.
- Dysregulated cellular metabolism in atherosclerosis: mediators and therapeutic opportunities.Stroope C, Nettersheim FS, Coon B, Finney AC, Schwartz MA, Ley K, Rom O, Yurdagul A Jr. Nat Metab. 2024 Apr; 2024 Mar 26. PMID: 38532071.
- Hearing loss promotes Alzheimer's disease.Zhao HB, Yang Y. Nat Aging. 2024 Apr. PMID: 38491290.
- Precision Oncology in Gastrointestinal and Colorectal Cancer Surgery.McDonald HG, Kerekes DM, Kim J, Khan SA. Surg Oncol Clin N Am. 2024 Apr; 2024 Jan 9. PMID: 38401913.
- Calcium flow at ER-TGN contact sites facilitates secretory cargo export.Ramazanov BR, Parchure A, Di Martino R, Kumar A, Chung M, Kim Y, Griesbeck O, Schwartz MA, Luini A, von Blume J. Mol Biol Cell. 2024 Apr 1; 2024 Jan 31. PMID: 38294859.
- Skeletal muscle TET3 promotes insulin resistance through destabilisation of PGC-1α.Liu B, Xie D, Huang X, Jin S, Dai Y, Sun X, Li D, Bennett AM, Diano S, Huang Y. Diabetologia. 2024 Apr; 2024 Jan 13. PMID: 38216792.
- The 8th International RASopathies Symposium: Expanding research and care practice through global collaboration and advocacy.Pierpont EI, Bennett AM, Schoyer L, Stronach B, Anschutz A, Borrie SC, Briggs B, Burkitt-Wright E, Castel P, Cirstea IC, Draaisma F, Ellis M, Fear VS, Frone MN, Flex E, Gelb BD, Green T, Gripp KW, Khoshkhoo S, Kieran MW, Kleemann K, Klein-Tasman BP, Kontaridis MI, Kruszka P, Leoni C, Liu CZ, Merchant N, Magoulas PL, Moertel C, Prada CE, Rauen KA, Roelofs R, Rossignol R, Sevilla C, Sevilla G, Sheedy R, Stieglitz E, Sun D, Tiemens D, White F, Wingbermühle E, Wolf C, Zenker M, Andelfinger G. Am J Med Genet A. 2024 Apr; 2023 Nov 15. PMID: 37969032.
- Integrin α3 is required for high-frequency repetitive transcranial magnetic stimulation-induced glutamatergic synaptic transmission in mice with ischemia.Liu L, Hu H, Wu J, Koleske AJ, Chen H, Wang N, Yu K, Wu Y, Xiao X, Zhang Q. CNS Neurosci Ther. 2024 Apr; 2023 Oct 23. PMID: 37867481.
- EGFR targeting PhosTACs as a dual inhibitory approach reveals differential downstream signaling.Hu Z, Chen PH, Li W, Krone M, Zheng S, Saarbach J, Velasco IU, Hines J, Liu Y, Crews CM. Sci Adv. 2024 Mar 29; 2024 Mar 27. PMID: 38536914.
- Unraveling cellular complexity with transient adapters in highly multiplexed super-resolution imaging.Schueder F, Rivera-Molina F, Su M, Marin Z, Kidd P, Rothman JE, Toomre D, Bewersdorf J. Cell. 2024 Mar 28. PMID: 38552613.
- Wnt5 controls splenic myelopoiesis and neutrophil functional ambivalency during DSS-induced colitis.Luan Y, Hu J, Wang Q, Wang X, Li W, Qu R, Yang C, Rajendran BK, Zhou H, Liu P, Zhang N, Shi Y, Liu Y, Tang W, Lu J, Wu D. Cell Rep. 2024 Mar 26; 2024 Mar 8. PMID: 38461416.
- Engineering self-propelled tumor-infiltrating CAR T cells using synthetic velocity receptors.Johnston AC, Alicea GM, Lee CC, Patel PV, Hanna EA, Vaz E, Forjaz A, Wan Z, Nair PR, Lim Y, Chen T, Du W, Kim D, Nichakawade TD, Rebecca VW, Bonifant CL, Fan R, Kiemen AL, Wu PH, Wirtz D. bioRxiv. 2024 Mar 26; 2024 Mar 26. PMID: 38168186.
- Auto-sumoylation of the Ubc9 E2 SUMO-conjugating Enzyme Extends Cellular Lifespan.Ryu HY, Jeong DW, Kim SY, Jeoung SW, Zhao D, Knight J, Lam T, Jin JH, Lee HS, Hochstrasser M. Res Sq. 2024 Mar 21; 2024 Mar 21. PMID: 38562857.
- Digital spatial proteomic profiling reveals immune checkpoints as biomarkers in lymphoid aggregates and tumor microenvironment of desmoplastic melanoma.Su DG, Schoenfeld DA, Ibrahim W, Cabrejo R, Djureinovic D, Baumann R, Rimm DL, Khan SA, Halaban R, Kluger HM, Olino K, Galan A, Clune J. J Immunother Cancer. 2024 Mar 21; 2024 Mar 21. PMID: 38519058.
- MAPK phosphatase 1 inhibition of p38α within lung myofibroblasts is essential for spontaneous fibrosis resolution.Fortier SM, Walker NM, Penke LR, Baas JD, Shen Q, Speth JM, Huang SK, Zemans RL, Bennett AM, Peters-Golden M. J Clin Invest. 2024 Mar 21; 2024 Mar 21. PMID: 38512415.
- MLL1 regulates cytokine-driven cell migration and metastasis.Nair PR, Danilova L, Gómez-de-Mariscal E, Kim D, Fan R, Muñoz-Barrutia A, Fertig EJ, Wirtz D. Sci Adv. 2024 Mar 15; 2024 Mar 13. PMID: 38478601.
- A proteome-wide quantitative platform for nanoscale spatially resolved extraction of membrane proteins into native nanodiscs.Brown C, Ghosh S, McAllister R, Kumar M, Walker G, Sun E, Aman T, Panda A, Kumar S, Li W, Coleman J, Liu Y, Rothman JE, Bhattacharyya M, Gupta K. bioRxiv. 2024 Mar 12; 2024 Mar 12. PMID: 38405833.
- microRNA-33 controls hunger signaling in hypothalamic AgRP neurons.Price NL, Fernández-Tussy P, Varela L, Cardelo MP, Shanabrough M, Aryal B, de Cabo R, Suárez Y, Horvath TL, Fernández-Hernando C. Nat Commun. 2024 Mar 8; 2024 Mar 8. PMID: 38459068.
- Developmental trajectory of cortical somatostatin interneuron function.Wang A, Ferguson KA, Gupta J, Higley MJ, Cardin JA. bioRxiv. 2024 Mar 7; 2024 Mar 7. PMID: 38496673.
- The art of observation: bridging science and art to see the unexpected.Gonzalez LE, Wei H, Greco V, Friedlaender LK. Development. 2024 Mar 1; 2024 Mar 13. PMID: 38477686.
- A New Mitochondrial Uncoupler Improves Metabolic Homeostasis in Mice.Ramshankar G, Perry RJ. Diabetes. 2024 Mar 1. PMID: 38377448.
- Novel muscle-derived extracellular matrix hydrogel promotes angiogenesis and neurogenesis in volumetric muscle loss.Chen Z, Huang Y, Xing H, Tseng T, Edelman H, Perry R, Kyriakides TR. Matrix Biol. 2024 Mar; 2024 Feb 6. PMID: 38325441.
- Metabolic underpinnings of cancer-related fatigue.Zhang X, Perry RJ. Am J Physiol Endocrinol Metab. 2024 Mar 1; 2024 Jan 31. PMID: 38294698.
- Thiazolidinedione enhances the efficacy of anti-PD-1 monoclonal antibody in murine melanoma.Zhang X, Gao Y, Tang K, Li Z, Halberstam AA, Zhou L, Perry RJ. Am J Physiol Endocrinol Metab. 2024 Mar 1; 2024 Jan 31. PMID: 38294697.
- Image-based multiplex immune profiling of cancer tissues: translational implications. A report of the International Immuno-oncology Biomarker Working Group on Breast Cancer.Jahangir CA, Page DB, Broeckx G, Gonzalez CA, Burke C, Murphy C, Reis-Filho JS, Ly A, Harms PW, Gupta RR, Vieth M, Hida AI, Kahila M, Kos Z, van Diest PJ, Verbandt S, Thagaard J, Khiroya R, Abduljabbar K, Acosta Haab G, Acs B, Adams S, Almeida JS, Alvarado-Cabrero I, Azmoudeh-Ardalan F, Badve S, Baharun NB, Bellolio ER, Bheemaraju V, Blenman KR, Botinelly Mendonça Fujimoto L, Burgues O, Chardas A, Cheang MCU, Ciompi F, Cooper LA, Coosemans A, Corredor G, Dantas Portela FL, Deman F, Demaria S, Dudgeon SN, Elghazawy M, Fernandez-Martín C, Fineberg S, Fox SB, Giltnane JM, Gnjatic S, Gonzalez-Ericsson PI, Grigoriadis A, Halama N, Hanna MG, Harbhajanka A, Hart SN, Hartman J, Hewitt S, Horlings HM, Husain Z, Irshad S, Janssen EA, Kataoka TR, Kawaguchi K, Khramtsov AI, Kiraz U, Kirtani P, Kodach LL, Korski K, Akturk G, Scott E, Kovács A, Laenkholm AV, Lang-Schwarz C, Larsimont D, Lennerz JK, Lerousseau M, Li X, Madabhushi A, Maley SK, Manur Narasimhamurthy V, Marks DK, McDonald ES, Mehrotra R, Michiels S, Kharidehal D, Minhas FUAA, Mittal S, Moore DA, Mushtaq S, Nighat H, Papathomas T, Penault-Llorca F, Perera RD, Pinard CJ, Pinto-Cardenas JC, Pruneri G, Pusztai L, Rajpoot NM, Rapoport BL, Rau TT, Ribeiro JM, Rimm D, Vincent-Salomon A, Saltz J, Sayed S, Hytopoulos E, Mahon S, Siziopikou KP, Sotiriou C, Stenzinger A, Sughayer MA, Sur D, Symmans F, Tanaka S, Taxter T, Tejpar S, Teuwen J, Thompson EA, Tramm T, Tran WT, van der Laak J, Verghese GE, Viale G, Wahab N, Walter T, Waumans Y, Wen HY, Yang W, Yuan Y, Bartlett J, Loibl S, Denkert C, Savas P, Loi S, Specht Stovgaard E, Salgado R, Gallagher WM, Rahman A. J Pathol. 2024 Mar; 2024 Jan 17. PMID: 38230434.
- High-Plex Assessment of Biomarkers in Tumors.Aung TN, Bates KM, Rimm DL. Mod Pathol. 2024 Mar; 2024 Jan 12. PMID: 38219953.
- Meeting Report on the 3rd Chinese American Society for Mass Spectrometry Conference-Advancing Biological and Pharmaceutical Mass Spectrometry.Chen H, Fu Y, Han M, Han X, Hao L, Huan T, Huang L, Huang M, Ji Q, Jiang T, Jiang Y, Li L, Li L, Liang X, Lih M, Lin Y, Liu X, Liu T, Liu Y, Ma S, Peng J, Qi YA, Qu J, Shou W, Sun L, Wang M, Wang S, Wu R, Wu S, Yan X, Yang J, Yang W, Yang Z, Yu Y, Zhang H, Zhang H, Zhao S, Zhu J, Zhu Y, Wang Y, Weng N. Biomed Chromatogr. 2024 Mar; 2023 Dec 10. PMID: 38071756.
- A plain language summary exploring a new treatment combination for untreated locally advanced or metastatic urothelial cancer: enfortumab vedotin plus pembrolizumab.Hoimes CJ, Flaig TW, Milowsky MI, Friedlander TW, Bilen MA, Gupta S, Srinivas S, Merchan JR, McKay RR, Petrylak DP, Sasse C, Moreno BH, Yu Y, Carret AS, Rosenberg JE. Future Oncol. 2024 Mar; 2023 Nov 23. PMID: 37994649.
- Plasticity-induced repression of Irf6 underlies acquired resistance to cancer immunotherapy in pancreatic ductal adenocarcinoma.Kim IK, Diamond MS, Yuan S, Kemp SB, Kahn BM, Li Q, Lin JH, Li J, Norgard RJ, Thomas SK, Merolle M, Katsuda T, Tobias JW, Baslan T, Politi K, Vonderheide RH, Stanger BZ. Nat Commun. 2024 Feb 20; 2024 Feb 20. PMID: 38378697.
- Spatial-temporal order-disorder transition in angiogenic NOTCH signaling controls cell fate specification.Kang TY, Bocci F, Nie Q, Onuchic JN, Levchenko A. Elife. 2024 Feb 20; 2024 Feb 20. PMID: 38376371.
- Effect of Burosumab on Muscle Function and Strength, and Rates of ATP Synthesis in Skeletal Muscle in Adults With XLH.Insogna KL, Sullivan R, Parziale S, Deng Y, Carrano D, Simpson C, Dufour S, Carpenter T, Petersen KF. J Clin Endocrinol Metab. 2024 Feb 20. PMID: 37930769.
- Distinct functional constraints driving conservation of the cofilin N-terminal regulatory tail.Sexton JA, Potchernikov T, Bibeau JP, Casanova-Sepúlveda G, Cao W, Lou HJ, Boggon TJ, De La Cruz EM, Turk BE. Nat Commun. 2024 Feb 16; 2024 Feb 16. PMID: 38365893.
- Microbiome Depletion Increases Fentanyl Self-Administration and Alters the Striatal Proteome Through Short-Chain Fatty Acids.Hofford RS, Meckel KR, Wiser EJ, Wang W, Sens JP, Kim M, Godino A, Lam TT, Kiraly DD. eNeuro. 2024 Feb; 2024 Feb 15. PMID: 38164564.
- Dual regulation of SLC25A39 by AFG3L2 and iron controls mitochondrial glutathione homeostasis.Shi X, DeCiucis M, Grabinska KA, Kanyo J, Liu A, Lam TT, Shen H. Mol Cell. 2024 Feb 15; 2023 Dec 28. PMID: 38157846.
- DHCR24-mediated sterol homeostasis during spermatogenesis is required for sperm mitochondrial sheath formation and impacts male fertility over time.Relovska S, Wang H, Zhang X, Fernández-Tussy P, Jeong KJ, Choi J, Suárez Y, McDonald JG, Fernández-Hernando C, Chung JJ. bioRxiv. 2024 Feb 11; 2024 Feb 11. PMID: 38187697.
- Heterogeneity of hepatocyte dynamics restores liver architecture after chemical, physical or viral damage.Ruz-Maldonado I, Gonzalez JT, Zhang H, Sun J, Bort A, Kabir I, Kibbey RG, Suárez Y, Greif DM, Fernández-Hernando C. Nat Commun. 2024 Feb 10; 2024 Feb 10. PMID: 38341404.