Cancer Signaling Networks Recent Publications

• Hypoxia is linked to acquired resistance to immune checkpoint inhibitors in lung cancer.Robles-Oteíza C, Hastings K, Choi J, Sirois I, Ravi A, Expósito F, de Miguel F, Knight JR, López-Giráldez F, Choi H, Socci ND, Merghoub T, Awad M, Getz G, Gainor J, Hellmann MD, Caron É, Kaech SM, Politi K. J Exp Med. 2025 Jan 6; 2024 Nov 25. PMID: 39585348.
• PTH-dependent stabilization of RANKL mRNA is associated with increased phosphorylation of the KH-type splicing regulatory protein.Yao GQ, Zhu M, Insogna K. Mol Cell Endocrinol. 2025 Jan 1; 2024 Nov 12. PMID: 39536935.
• Regulation and signaling of the LIM domain kinases.Casanova-Sepúlveda G, Boggon TJ. Bioessays. 2025 Jan; 2024 Oct 3. PMID: 39361252.
• Development of an Objective Structured Assessment of Technical Skills for Sclerotherapy.Ma MS, Zafar FS, Goldman MP, Munavalli GS, Zimmet SE, Nguyen TH, Mishra V, Cartee TV, Mann M, Hsu JTS, Silapunt S, Weiss RA, Weiss MA, Haq M, Ahmed A, Koza E, Shi VJ, Dave L, Yi M, Kang BY, Cahn B, Bae YSC, Kole LCS, Friedmann DP, Chow ML, Minkis K, Stücker M, Schlick CA, Hoss E, Hu JC, Kibbi N, Saikaly SK, Greywal T, Hooper D, Vashi NA, Boucher A, Ward KHM, Neuhaus IM, Ghareeb E, Luke J, Karen JK, Suggs A, Lucas J, Decker A, Brieva JC, Yoo SS, Suozzi K, Alam M. J Am Acad Dermatol. 2025 Jan; 2024 Sep 15. PMID: 39288871.
• Vesicle docking and fusion pore modulation by the neuronal calcium sensor Synaptotagmin-1.Tsemperouli M, Cheppali SK, Molina FR, Chetrit D, Landajuela A, Toomre D, Karatekin E. Biophys J. 2024 Dec 23; 2024 Dec 23. PMID: 39719826.
• Author Correction: π-HuB: the proteomic navigator of the human body.He F, Aebersold R, Baker MS, Bian X, Bo X, Chan DW, Chang C, Chen L, Chen X, Chen YJ, Cheng H, Collins BC, Corrales F, Cox J, E W, Van Eyk JE, Fan J, Faridi P, Figeys D, Gao GF, Gao W, Gao ZH, Goda K, Goh WWB, Gu D, Guo C, Guo T, He Y, Heck AJR, Hermjakob H, Hunter T, Iyer NG, Jiang Y, Jimenez CR, Joshi L, Kelleher NL, Li M, Li Y, Lin Q, Liu CH, Liu F, Liu GH, Liu Y, Liu Z, Low TY, Lu B, Mann M, Meng A, Moritz RL, Nice E, Ning G, Omenn GS, Overall CM, Palmisano G, Peng Y, Pineau C, Poon TCW, Purcell AW, Qiao J, Reddel RR, Robinson PJ, Roncada P, Sander C, Sha J, Song E, Srivastava S, Sun A, Sze SK, Tang C, Tang L, Tian R, Vizcaíno JA, Wang C, Wang C, Wang X, Wang X, Wang Y, Weiss T, Wilhelm M, Winkler R, Wollscheid B, Wong L, Xie L, Xie W, Xu T, Xu T, Yan L, Yang J, Yang X, Yates J, Yun T, Zhai Q, Zhang B, Zhang H, Zhang L, Zhang L, Zhang P, Zhang Y, Zheng YZ, Zhong Q, Zhu Y. Nature. 2024 Dec 23; 2024 Dec 23. PMID: 39715925.
• Genetic Analysis of Epidermal Inclusion Cysts Reveals NEK9 as a Common Driver of Comedogenesis and Cyst Formation.Ellis KT, Myung P, Cohen J, Choate KA. J Invest Dermatol. 2024 Dec 18; 2024 Dec 18. PMID: 39706256.
• SGLT2 inhibition alters substrate utilization and mitochondrial redox in healthy and failing rat hearts.Goedeke L, Ma Y, Gaspar RC, Nasiri A, Lee J, Zhang D, Galsgaard KD, Hu X, Zhang J, Guerrera N, Li X, LaMoia T, Hubbard BT, Haedersdal S, Wu X, Stack J, Dufour S, Butrico GM, Kahn M, Perry RJ, Cline GW, Young LH, Shulman GI. J Clin Invest. 2024 Dec 16; 2024 Dec 16. PMID: 39680452.
• Trastuzumab Deruxtecan with Nivolumab in HER2-Expressing Metastatic Breast or Urothelial Cancer: Analysis of the Phase Ib DS8201-A-U105 Study.Hamilton E, Galsky MD, Ochsenreither S, Del Conte G, Martín M, De Miguel MJ, Yu EY, Williams A, Gion M, Tan AR, Agrawal L, Rutten A, Machiels JP, Cresta S, Debruyne PR, Hennequin A, Moreno V, Minchom A, Valdes-Albini F, Petrylak D, Li L, Tsuchihashi Z, Suto F, Cheng FC, Kandil M, Barrios D, Hurvitz S. Clin Cancer Res. 2024 Dec 16. PMID: 39405343.
• Phase separation of microtubule-binding proteins - implications for neuronal function and disease.Duan D, Koleske AJ. J Cell Sci. 2024 Dec 15; 2024 Dec 13. PMID: 39679446.
• Conformational response of α(IIb)β(3) and α(V)β(3) integrins to force.Kolasangiani R, Farzanian K, Chen Y, Schwartz MA, Bidone TC. Structure. 2024 Dec 12; 2024 Dec 12. PMID: 39706199.
• Intracellular endothelial cell metabolism in vascular function and dysfunction.Citrin KM, Chaube B, Fernández-Hernando C, Suárez Y. Trends Endocrinol Metab. 2024 Dec 12; 2024 Dec 12. PMID: 39672762.
• DNA nanodevice for analysis of force-activated protein extension and interactions.Zhou K, Chung M, Cheng J, Powell JT, Yan Q, Liu J, Xiong Y, Schwartz MA, Lin C. bioRxiv. 2024 Dec 11; 2024 Dec 11. PMID: 39554144.
• Renal Angptl4 is a key fibrogenic molecule in progressive diabetic kidney disease.Srivastava SP, Zhou H, Shenoi R, Morris M, Lainez-Mas B, Goedeke L, Rajendran BK, Setia O, Aryal B, Kanasaki K, Koya D, Inoki K, Dardik A, Bell T 3rd, Fernández-Hernando C, Shulman GI, Goodwin JE. Sci Adv. 2024 Dec 6; 2024 Dec 4. PMID: 39630889.
• OST Catalytic Subunit Redundancy Enables Therapeutic Targeting of N-Glycosylation.Baro M, Lee H, Kelley V, Lou R, Phoomak C, Politi K, Zeiss CJ, Van Zandt M, Contessa JN. bioRxiv. 2024 Dec 5; 2024 Dec 5. PMID: 39677793.
• Polycomb Repressive Complex 2 promotes atherosclerotic plaque vulnerability.Joshi D, Chakraborty R, Bhogale T, Furtado J, Deng H, Traylor JG Jr, Orr AW, Martin KA, Schwartz MA. bioRxiv. 2024 Dec 2; 2024 Dec 2. PMID: 39703699.
• π-HuB: the proteomic navigator of the human body.He F, Aebersold R, Baker MS, Bian X, Bo X, Chan DW, Chang C, Chen L, Chen X, Chen YJ, Cheng H, Collins BC, Corrales F, Cox J, E W, Van Eyk JE, Fan J, Faridi P, Figeys D, Gao GF, Gao W, Gao ZH, Goda K, Goh WWB, Gu D, Guo C, Guo T, He Y, Heck AJR, Hermjakob H, Hunter T, Iyer NG, Jiang Y, Jimenez CR, Joshi L, Kelleher NL, Li M, Li Y, Lin Q, Liu CH, Liu F, Liu GH, Liu Y, Liu Z, Low TY, Lu B, Mann M, Meng A, Moritz RL, Nice E, Ning G, Omenn GS, Overall CM, Palmisano G, Peng Y, Pineau C, Poon TCW, Purcell AW, Qiao J, Reddel RR, Robinson PJ, Roncada P, Sander C, Sha J, Song E, Srivastava S, Sun A, Sze SK, Tang C, Tang L, Tian R, Vizcaíno JA, Wang C, Wang C, Wang X, Wang X, Wang Y, Weiss T, Wilhelm M, Winkler R, Wollscheid B, Wong L, Xie L, Xie W, Xu T, Xu T, Yan L, Yang J, Yang X, Yates J, Yun T, Zhai Q, Zhang B, Zhang H, Zhang L, Zhang L, Zhang P, Zhang Y, Zheng YZ, Zhong Q, Zhu Y. Nature. 2024 Dec; 2024 Dec 11. PMID: 39663494.
• Integrative spatial protein profiling with multi-omics.Fan R. Nat Methods. 2024 Dec. PMID: 39643677.
• The analytical and clinical validity of AI algorithms to score TILs in TNBC: can we use different machine learning models interchangeably?Vidal JM, Tsiknakis N, Staaf J, Bosch A, Ehinger A, Nimeus E, Salgado R, Bai Y, Rimm DL, Hartman J, Acs B. EClinicalMedicine. 2024 Dec; 2024 Nov 15. PMID: 39634035.
• Implementing evidence-based strategies for men with biochemically recurrent and advanced prostate cancer: Consensus recommendations from the US Prostate Cancer Conference 2024.Bryce AH, Agarwal N, Beltran H, Hussain MH, Sartor O, Shore N, Antonarakis ES, Armstrong AJ, Calais J, Carducci MA, Dorff TB, Efstathiou JA, Gleave M, Gomella LG, Higano C, Hope TA, Iagaru A, Morgans AK, Morris DS, Morris MJ, Petrylak DP, Reiter RE, Rettig MB, Ryan CJ, Sellinger SB, Spratt DE, Srinivas S, Tagawa ST, Taplin ME, Yu EY, Zhang T, McKay RR, Koo PJ, Crawford ED. Cancer. 2024 Dec 1; 2024 Dec 1. PMID: 39616467.
• The mouse metabolic phenotyping center (MMPC) live consortium: an NIH resource for in vivo characterization of mouse models of diabetes and obesity.Laughlin M, McIndoe R, Adams SH, Araiza R, Ayala JE, Kennedy L, Lanoue L, Lantier L, Macy J, Malabanan E, McGuinness OP, Perry R, Port D, Qi N, Elias CF, Shulman GI, Wasserman DH, Lloyd KCK. Mamm Genome. 2024 Dec; 2024 Aug 27. PMID: 39191872.
• Phosphoenolpyruvate carboxykinase-2 (PCK2) is a therapeutic target in triple-negative breast cancer.Gunasekharan V, Lin HK, Marczyk M, Rios-Hoyo A, Campos GE, Shan NL, Ahmed M, Umlauf S, Gareiss P, Raaisa R, Williams R, Cardone R, Siebel S, Kibbey R, Surovtseva YV, Pusztai L. Breast Cancer Res Treat. 2024 Dec; 2024 Aug 23. PMID: 39177932.
• SenNet recommendations for detecting senescent cells in different tissues.Suryadevara V, Hudgins AD, Rajesh A, Pappalardo A, Karpova A, Dey AK, Hertzel A, Agudelo A, Rocha A, Soygur B, Schilling B, Carver CM, Aguayo-Mazzucato C, Baker DJ, Bernlohr DA, Jurk D, Mangarova DB, Quardokus EM, Enninga EAL, Schmidt EL, Chen F, Duncan FE, Cambuli F, Kaur G, Kuchel GA, Lee G, Daldrup-Link HE, Martini H, Phatnani H, Al-Naggar IM, Rahman I, Nie J, Passos JF, Silverstein JC, Campisi J, Wang J, Iwasaki K, Barbosa K, Metis K, Nernekli K, Niedernhofer LJ, Ding L, Wang L, Adams LC, Ruiyang L, Doolittle ML, Teneche MG, Schafer MJ, Xu M, Hajipour M, Boroumand M, Basisty N, Sloan N, Slavov N, Kuksenko O, Robson P, Gomez PT, Vasilikos P, Adams PD, Carapeto P, Zhu Q, Ramasamy R, Perez-Lorenzo R, Fan R, Dong R, Montgomery RR, Shaikh S, Vickovic S, Yin S, Kang S, Suvakov S, Khosla S, Garovic VD, Menon V, Xu Y, Song Y, Suh Y, Dou Z, Neretti N. Nat Rev Mol Cell Biol. 2024 Dec; 2024 Jun 3. PMID: 38831121.
• Rapid and sustained improvements in itch and quality of life with upadacitinib plus topical corticosteroids in adults and adolescents with atopic dermatitis: 52-week outcomes from the phase 3 AD Up study.Magnolo N, Cameron MC, Shahriari M, Geng B, Calimlim BM, Teixeira H, Hu X, Yang Y, Liu Y, Zhang S, Sancho Sanchez C, Altman K, Langley RG. J Dermatolog Treat. 2024 Dec; 2024 May 2. PMID: 38697950.
• Corrigendum to "PTH-dependent stabilization of RANKL mRNA is associated with increased phosphorylation of the KH-type splicing regulatory protein" [Molecul. Cellul. Endocrinol. 595 (2025) 112412].Yao GQ, Zhu M, Insogna K. Mol Cell Endocrinol. 2024 Nov 29; 2024 Nov 29. PMID: 39616004.
• GABA(A) receptor π forms channels that stimulate ERK through a G-protein-dependent pathway.Wang Y, Zhang Y, Li W, Salovska B, Zhang J, Li T, Li H, Liu Y, Kaczmarek LK, Pusztai L, Klein DE. Mol Cell. 2024 Nov 28; 2024 Nov 28. PMID: 39642883.
• A proteome-wide quantitative platform for nanoscale spatially resolved extraction of membrane proteins into native nanodiscs.Brown C, Ghosh S, McAllister R, Kumar M, Walker G, Sun E, Aman T, Panda A, Kumar S, Li W, Coleman J, Liu Y, Rothman JE, Bhattacharyya M, Gupta K. Nat Methods. 2024 Nov 28; 2024 Nov 28. PMID: 39609567.
• Mitogen-Activated Protein Kinase Phosphatase-5 is Required for TGF-β Signaling Through a JNK-Dependent Pathway.Dorry S, Perla S, Bennett AM. Mol Cell Biol. 2024 Nov 28; 2024 Nov 28. PMID: 39607740.
• Setdb1-loss induces type-I interferons and immune clearance of melanoma.McGeary MK, Damsky W, Daniels AJ, Lang SM, Xu Q, Song E, Huet-Calderwood C, Lou HJ, Paradkar S, Micevic G, Kaech SM, Calderwood DA, Turk BE, Yan Q, Iwasaki A, Bosenberg MW. Cancer Immunol Res. 2024 Nov 26; 2024 Nov 26. PMID: 39589394.
• A proteogenomic analysis of cervical cancer reveals therapeutic and biological insights.Yu J, Gui X, Zou Y, Liu Q, Yang Z, An J, Guo X, Wang K, Guo J, Huang M, Zhou S, Zuo J, Chen Y, Deng L, Yuan G, Li N, Song Y, Jia J, Zeng J, Zhao Y, Liu X, Du X, Liu Y, Wang P, Zhang B, Ding L, Robles AI, Rodriguez H, Zhou H, Shao Z, Wu L, Gao D. Nat Commun. 2024 Nov 22; 2024 Nov 22. PMID: 39578447.
• Systematic analysis identifies a connection between spatial and genomic variations of chromatin states.Cao X, Ma T, Fan R, Yuan GC. Cell Syst. 2024 Nov 20; 2024 Nov 13. PMID: 39541982.
• Spatially Resolved in vivo CRISPR Screen Sequencing via Perturb-DBiT.Baysoy A, Tian X, Zhang F, Renauer P, Bai Z, Shi H, Li H, Tao B, Yang M, Enninful A, Gao F, Wang G, Zhang W, Tran T, Patterson NH, Bao S, Dong C, Xin S, Zhong M, Rankin S, Guy C, Wang Y, Connelly JP, Pruett-Miller SM, Chi H, Chen S, Fan R. bioRxiv. 2024 Nov 19; 2024 Nov 19. PMID: 39605490.
• Decoy-resistant IL-18 reshapes the tumor microenvironment and enhances rejection by anti-CTLA-4 in renal cell carcinoma.Schoenfeld DA, Djureinovic D, Su DG, Zhang L, Lu BY, Kamga L, Mann JE, Huck JD, Hurwitz M, Braun DA, Jilaveanu L, Ring AM, Kluger HM. JCI Insight. 2024 Nov 19; 2024 Nov 19. PMID: 39561007.
• RNA sample optimization for cryo-EM analysis.Chen X, Wang L, Xie J, Nowak JS, Luo B, Zhang C, Jia G, Zou J, Huang D, Glatt S, Yang Y, Su Z. Nat Protoc. 2024 Nov 15; 2024 Nov 15. PMID: 39548288.
• Limiting 20S proteasome assembly leads to unbalanced nucleo-cytoplasmic distribution of 26S/30S proteasomes and chronic proteotoxicity.Ruiz-Romero G, Berdún MD, Hochstrasser M, Salas-Pino S, Daga RR. iScience. 2024 Nov 15; 2024 Oct 4. PMID: 39473973.
• Association of T-cell subtypes with macrophage-specific arterial infiltration in people with HIV.Schnittman SR, Talathi R, Wilks MQ, Hedgire S, Lu MT, Fourman LT, Alagpulinsa DA, Stockman SL, White KS, Wallis ZK, Autissier P, Stanley TL, Lee H, Honigberg MC, El-Fakhri G, Williams KC, Zanni MV, Grinspoon SK, Toribio M. AIDS. 2024 Nov 15; 2024 Jun 20. PMID: 38905489.
• Sorafenib or anthracycline-based chemotherapy for progressive desmoid tumors.Costa PA, Arora A, Fernandez Y, Yi I, Bakkila B, Tan H, Barreto Coelho P, Campoverde L, Hardy N, Bialick S, Espejo Freire A, D'Amato GZ, Chang YC, Mesenger JP, Subhawong T, Haims A, Hurwitz M, Olino K, Turaga K, Deshpande H, Trent J. Cancer. 2024 Nov 14; 2024 Nov 14. PMID: 39543805.
• Spatiotemporal control of subcellular O-GlcNAc signaling using Opto-OGT.Ong Q, Lim LTR, Goh C, Liao Y, Chan SE, Lim CJY, Kam V, Yap J, Tseng T, Desrouleaux R, Wang LC, Ler SG, Lim SL, Kim SY, Sobota RM, Bennett AM, Han W, Yang X. Nat Chem Biol. 2024 Nov 14; 2024 Nov 14. PMID: 39543398.
• Spatially exploring RNA biology in archival formalin-fixed paraffin-embedded tissues.Bai Z, Zhang D, Gao Y, Tao B, Zhang D, Bao S, Enninful A, Wang Y, Li H, Su G, Tian X, Zhang N, Xiao Y, Liu Y, Gerstein M, Li M, Xing Y, Lu J, Xu ML, Fan R. Cell. 2024 Nov 14; 2024 Sep 30. PMID: 39353436.
• Focal adhesion-derived liquid-liquid phase separations regulate mRNA translation.Kumar A, Tanaka K, Schwartz MA. bioRxiv. 2024 Nov 14; 2024 Nov 14. PMID: 38045367.
• Metastasis of colon cancer requires Dickkopf-2 to generate cancer cells with Paneth cell properties.Shin JH, Park J, Lim J, Jeong J, Dinesh RK, Maher SE, Kim J, Park S, Hong JY, Wysolmerski J, Choi J, Bothwell ALM. Elife. 2024 Nov 13; 2024 Nov 13. PMID: 39535280.
• Master regulators governing protein abundance across ten human cancer types.Wang Z, Wojciechowicz M, Rosen J, Elmas A, Song WM, Liu Y, Huang KL. bioRxiv. 2024 Nov 12; 2024 Nov 12. PMID: 39605415.
• Protein Tyrosine Phosphatases in Metabolism: A New Frontier for Therapeutics.Bennett AM, Tiganis T. Annu Rev Physiol. 2024 Nov 12; 2024 Nov 12. PMID: 39531392.
• Integration of Imaging-based and Sequencing-based Spatial Omics Mapping on the Same Tissue Section via DBiTplus.Enninful A, Zhang Z, Klymyshyn D, Zong H, Bai Z, Farzad N, Su G, Baysoy A, Nam J, Yang M, Lu Y, Zhang NR, Braubach O, Xu ML, Ma Z, Fan R. bioRxiv. 2024 Nov 11; 2024 Nov 11. PMID: 39605581.
• Detection of live attenuated measles virus in the respiratory tract following subcutaneous MMR Vaccination.Watkins TA, Brockhurst JK, Germain G, Griffin DE, Foxman EF. J Infect Dis. 2024 Nov 6; 2024 Nov 6. PMID: 39504437.
• Disentangling Race from Skin Color in Modern Biology and Medicine.Horsley V, Dadzie OE, Hall R, Jablonski NG. J Invest Dermatol. 2024 Nov 6; 2024 Nov 6. PMID: 39503695.
• Aurora B controls anaphase onset and error-free chromosome segregation in trypanosomes.Ballmer D, Lou HJ, Ishii M, Turk BE, Akiyoshi B. J Cell Biol. 2024 Nov 4; 2024 Aug 28. PMID: 39196069.
• A complex of the lipid transport ER proteins TMEM24 and C2CD2 with band 4.1 at cell-cell contacts.Johnson B, Iuliano M, Lam TT, Biederer T, De Camilli PV. J Cell Biol. 2024 Nov 4; 2024 Aug 19. PMID: 39158698.
• Deletion of miR-33, a regulator of the ABCA1-APOE pathway, ameliorates neuropathological phenotypes in APP/PS1 mice.Tate M, Wijeratne HRS, Kim B, Philtjens S, You Y, Lee DH, Gutierrez DA, Sharify D, Wells M, Perez-Cardelo M, Doud EH, Fernandez-Hernando C, Lasagna-Reeves C, Mosley AL, Kim J. Alzheimers Dement. 2024 Nov; 2024 Sep 30. PMID: 39345217.
• Chitinase 3-like-1 (CHI3L1) in the pathogenesis of epidermal growth factor receptor mutant non-small cell lung cancer.Kamle S, Ma B, Schor G, Bailey M, Pham B, Cho I, Khan H, Azzoli C, Hofstetter M, Sadanaga T, Herbst R, Politi K, Lee CG, Elias JA. Transl Oncol. 2024 Nov; 2024 Aug 22. PMID: 39178575.
• Item Response Theory Quantifies the Relationship Between Improvements in Serum Phosphate and Patient-Reported Outcomes in Adults With X-Linked Hypophosphatemia.Mehta K, Gosselin NH, Insogna K, Barriere O, Quattrocchi E, Hruska MW, Marsteller D. Clin Pharmacol Ther. 2024 Nov; 2024 Aug 12. PMID: 39129452.
• Spatially resolved epigenome sequencing via Tn5 transposition and deterministic DNA barcoding in tissue.Farzad N, Enninful A, Bao S, Zhang D, Deng Y, Fan R. Nat Protoc. 2024 Nov; 2024 Jun 28. PMID: 38943021.
• Mapping intratumoral myeloid-T cell interactomes at single-cell resolution reveals targets for overcoming checkpoint inhibitor resistance.Bridges K, Pizzurro GA, Baysoy A, Baskaran JP, Xu Z, Mathew V, Tripple V, LaPorte M, Park K, Damsky W, Kluger H, Fan R, Kaech SM, Bosenberg MW, Miller-Jensen K. bioRxiv. 2024 Oct 31; 2024 Oct 31. PMID: 39554094.
• A Comprehensive and Robust Multiplex-DIA Workflow Profiles Protein Turnover Regulations Associated with Cisplatin Resistance.Salovska B, Li W, Bernhardt OM, Germain PL, Gandhi T, Reiter L, Liu Y. bioRxiv. 2024 Oct 31; 2024 Oct 31. PMID: 39554001.
• Single-cell transcriptomic and proteomic analysis of Parkinson's disease brains.Zhu B, Park JM, Coffey SR, Russo A, Hsu IU, Wang J, Su C, Chang R, Lam TT, Gopal PP, Ginsberg SD, Zhao H, Hafler DA, Chandra SS, Zhang L. Sci Transl Med. 2024 Oct 30; 2024 Oct 30. PMID: 39475571.
• Abl kinases regulate FGF signaling independent of Crk phosphorylation to prevent Peters anomaly.Wu H, Mao Y, Wang Q, Yu H, Bouaziz M, Makrides N, Koleske AJ, Radice GL, Zhang X. bioRxiv. 2024 Oct 26; 2024 Oct 26. PMID: 39484567.
• Human-mouse proteomics reveals the shared pathways in Alzheimer's disease and delayed protein turnover in the amyloidome.Yarbro JM, Han X, Dasgupta A, Yang K, Liu D, Shrestha HK, Zaman M, Wang Z, Yu K, Lee DG, Vanderwall D, Niu M, Sun H, Xie B, Chen PC, Jiao Y, Zhang X, Wu Z, Fu Y, Li Y, Yuan ZF, Wang X, Poudel S, Vagnerova B, He Q, Tang A, Ronaldson PT, Chang R, Yu G, Liu Y, Peng J. bioRxiv. 2024 Oct 25; 2024 Oct 25. PMID: 39484428.
• Don't be so naïve.Horsley V, Nasserdine A. Elife. 2024 Oct 25; 2024 Oct 25. PMID: 39453398.
• A disease-associated PPP2R3C-MAP3K1 phospho-regulatory module controls centrosome function.Ganga AK, Sweeney LK, Rubio Ramos A, Wrinn CM, Bishop CS, Hamel V, Guichard P, Breslow DK. Curr Biol. 2024 Oct 21; 2024 Sep 23. PMID: 39317195.
• An Extensive Atlas of Proteome and Phosphoproteome Turnover Across Mouse Tissues and Brain Regions.Li W, Dasgupta A, Yang K, Wang S, Hemandhar-Kumar N, Yarbro JM, Hu Z, Salovska B, Fornasiero EF, Peng J, Liu Y. bioRxiv. 2024 Oct 17; 2024 Oct 17. PMID: 39464138.
• DeepO-GlcNAc: a web server for prediction of protein O-GlcNAcylation sites using deep learning combined with attention mechanism.Zhang L, Deng T, Pan S, Zhang M, Zhang Y, Yang C, Yang X, Tian G, Mi J. Front Cell Dev Biol. 2024; 2024 Oct 10. PMID: 39450274.
• TROPHY-U-01 Cohort 2: A Phase II Study of Sacituzumab Govitecan in Cisplatin-Ineligible Patients With Metastatic Urothelial Cancer Progressing After Previous Checkpoint Inhibitor Therapy.Petrylak DP, Tagawa ST, Jain RK, Bupathi M, Balar A, Kalebasty AR, George S, Palmbos P, Nordquist L, Davis N, Ramamurthy C, Sternberg CN, Loriot Y, Agarwal N, Park C, Tonelli J, Vance M, Zhou H, Grivas P. J Clin Oncol. 2024 Oct 10; 2024 Aug 26. PMID: 39186707.
• SIMVI reveals intrinsic and spatial-induced states in spatial omics data.Dong M, Su D, Kluger H, Fan R, Kluger Y. bioRxiv. 2024 Oct 10; 2024 Oct 10. PMID: 37693629.
• DNA-Based Molecular Clamp for Probing Protein Interactions and Structure under Force.Chung M, Zhou K, Powell JT, Lin C, Schwartz MA. ACS Nano. 2024 Oct 8; 2024 Sep 29. PMID: 39344156.
• Heterozygosity for neurodevelopmental disorder-associated TRIO variants yields distinct deficits in behavior, neuronal development, and synaptic transmission in mice.Ishchenko Y, Jeng AT, Feng S, Nottoli T, Manriquez-Rodriguez C, Nguyen KK, Carrizales MG, Vitarelli MJ, Corcoran EE, Greer CA, Myers SA, Koleske AJ. bioRxiv. 2024 Oct 8; 2024 Oct 8. PMID: 39131289.
• Selective utilization of glucose metabolism guides mammalian gastrulation.Cao D, Bergmann J, Zhong L, Hemalatha A, Dingare C, Jensen T, Cox AL, Greco V, Steventon B, Sozen B. Nature. 2024 Oct; 2024 Oct 16. PMID: 39415005.
• Feeding the wrath with myelin.Ghosh S, Rothlin CV. Trends Immunol. 2024 Oct; 2024 Sep 27. PMID: 39341708.
• The type 2 cytokine Fc-IL-4 revitalizes exhausted CD8(+) T cells against cancer.Feng B, Bai Z, Zhou X, Zhao Y, Xie YQ, Huang X, Liu Y, Enbar T, Li R, Wang Y, Gao M, Bonati L, Peng MW, Li W, Tao B, Charmoy M, Held W, Melenhorst JJ, Fan R, Guo Y, Tang L. Nature. 2024 Oct; 2024 Sep 25. PMID: 39322665.
• Single-cell CAR T atlas reveals type 2 function in 8-year leukaemia remission.Bai Z, Feng B, McClory SE, de Oliveira BC, Diorio C, Gregoire C, Tao B, Yang L, Zhao Z, Peng L, Sferruzza G, Zhou L, Zhou X, Kerr J, Baysoy A, Su G, Yang M, Camara PG, Chen S, Tang L, June CH, Melenhorst JJ, Grupp SA, Fan R. Nature. 2024 Oct; 2024 Sep 25. PMID: 39322664.
• Cytosolic calcium regulates hepatic mitochondrial oxidation, intrahepatic lipolysis, and gluconeogenesis via CAMKII activation.LaMoia TE, Hubbard BT, Guerra MT, Nasiri A, Sakuma I, Kahn M, Zhang D, Goodman RP, Nathanson MH, Sancak Y, Perelis M, Mootha VK, Shulman GI. Cell Metab. 2024 Oct 1; 2024 Aug 16. PMID: 39153480.
• Trends in breast cancer specific death by clinical stage at diagnoses between 2000-2017.Marczyk M, Kahn A, Silber A, Rosenblit M, Digiovanna MP, Lustberg M, Pusztai L. J Natl Cancer Inst. 2024 Sep 30; 2024 Sep 30. PMID: 39348186.
• Metastasis of colon cancer requires Dickkopf-2 to generate cancer cells with Paneth cell properties.Shin JH, Park J, Lim J, Jeong J, Dinesh RK, Maher SE, Kim J, Park S, Hong JY, Wysolmerski J, Choi J, Bothwell ALM. bioRxiv. 2024 Sep 25; 2024 Sep 25. PMID: 38659853.
• Adaptation of the socioecological model to address disparities in engagement of Black men in prostate cancer genetic testing.Leader AE, Rebbeck TR, Oh WK, Patel AV, Winer EP, Bailey LO, Gomella LG, Lumpkins CY, Garraway IP, Aiello LB, Baskin ML, Cheng HH, Cooney KA, Ganzak A, George DJ, Halabi S, Hathaway F, Healy C, Kim JW, Leapman MS, Loeb S, Maxwell KN, McNair C, Morgan TM, Prindeville B, Soule HR, Steward WL, Suttiratana SC, Taplin ME, Yamoah K, Fortune T, Bennett K, Blanding-Godbolt J, Gross L, Giri VN. BMC Public Health. 2024 Sep 18; 2024 Sep 18. PMID: 39289635.
• PTMoreR-enabled cross-species PTM mapping and comparative phosphoproteomics across mammals.Wang S, Di Y, Yang Y, Salovska B, Li W, Hu L, Yin J, Shao W, Zhou D, Cheng J, Liu D, Yang H, Liu Y. Cell Rep Methods. 2024 Sep 16; 2024 Sep 9. PMID: 39255793.
• Adjuvant Pembrolizumab versus Observation in Muscle-Invasive Urothelial Carcinoma.Apolo AB, Ballman KV, Sonpavde G, Berg S, Kim WY, Parikh R, Teo MY, Sweis RF, Geynisman DM, Grivas P, Chatta G, Reichert ZR, Kim JW, Bilen MA, McGregor B, Singh P, Tripathi A, Cole S, Simon N, Niglio S, Ley L, Cordes L, Srinivas S, Huang J, Odegaard M, Watt C, Petrylak D, Hoffman-Censits J, Wen Y, Hahn O, Mitchell C, Tan A, Streicher H, Sharon E, Moon H, Woods M, Halabi S, Perez Burbano G, Morris MJ, Rosenberg JE. N Engl J Med. 2024 Sep 15; 2024 Sep 15. PMID: 39282902.
• CALHM2 is a mitochondrial protein import channel that regulates fatty acid metabolism.Jonas E, Mnatsakanyan N, Rivera-Molina F, Robson A, Garfinkel AM, Kumar A, Batter S, Padovano V, Webster K, Cardone R, Berg J, Toomre D, Kibbey R 4th, Caplan M, Khokha M. Res Sq. 2024 Sep 13; 2024 Sep 13. PMID: 39315269.
• Vesicle docking and fusion pore modulation by the neuronal calcium sensor Synaptotagmin-1.Tsemperouli M, Cheppali SK, Molina FR, Chetrit D, Landajuela A, Toomre D, Karatekin E. bioRxiv. 2024 Sep 12; 2024 Sep 12. PMID: 39314345.
• Proteomic Profile of Circulating Extracellular Vesicles in the Brain after Δ9-Tetrahydrocannabinol Inhalation.Lallai V, Lam TT, Garcia-Milian R, Chen YC, Fowler JP, Manca L, Piomelli D, Williams K, Nairn AC, Fowler CD. Biomolecules. 2024 Sep 10; 2024 Sep 10. PMID: 39334909.
• Phosphorylation of the nuclear poly(A) binding protein (PABPN1) during mitosis protects mRNA from hyperadenylation and maintains transcriptome dynamics.Gordon JM, Phizicky DV, Schärfen L, Brown CL, Arias Escayola D, Kanyo J, Lam TT, Simon MD, Neugebauer KM. Nucleic Acids Res. 2024 Sep 9. PMID: 38943343.
• Dynamic and structural insights into allosteric regulation on MKP5 a dual-specificity phosphatase.Skeens E, Maschietto F, Manjula R, Shillingford S, Lolis EJ, Batista VS, Bennett AM, Lisi GP. bioRxiv. 2024 Sep 5; 2024 Sep 5. PMID: 39282375.
• Structural insights into the role and targeting of EGFRvIII.Bagchi A, Stayrook SE, Xenaki KT, Starbird CA, Doulkeridou S, El Khoulati R, Roovers RC, Schmitz KR, van Bergen En Henegouwen PMP, Ferguson KM. Structure. 2024 Sep 5; 2024 Jun 21. PMID: 38908376.
• Promoting Collaborative Scholarship During the COVID-19 Pandemic Through an Innovative COVID-19 Data Explorer and Repository at Yale School of Medicine: Development and Usability Study.Victoria-Castro AM, Arora T, Simonov M, Biswas A, Alausa J, Subair L, Gerber B, Nguyen A, Hsiao A, Hintz R, Yamamoto Y, Soufer R, Desir G, Wilson FP, Villanueva M. JMIR Form Res. 2024 Sep 3; 2024 Sep 3. PMID: 39226547.
• Cost trends of metastatic renal cell carcinoma therapy: the impact of oral anticancer agents and immunotherapy.Forman R, Long JB, Westvold SJ, Agnish K, Mcmanus HD, Leapman MS, Hurwitz ME, Spees LP, Wheeler SB, Gross CP, Dinan MA. JNCI Cancer Spectr. 2024 Sep 2. PMID: 39133171.
• High burden of viruses and bacterial pathobionts drives heightened nasal innate immunity in children.Watkins TA, Green AB, Amat JAR, Cheemarla NR, Hänsel K, Lozano R, Dudgeon SN, Germain G, Landry ML, Schulz WL, Foxman EF. J Exp Med. 2024 Sep 2; 2024 Jul 1. PMID: 38949638.
• Evaluating Treatment Patterns and the Role of Neoadjuvant Chemotherapy in Plasmacytoid Urothelial Carcinoma: Insights from a Combined National and Institutional Series.Rahman S, Kong V, Jalfon M, Hesse D, Kim J, Wright JL, Adeniran A, Humphrey P, Martin DT, Ghali F. Cancers (Basel). 2024 Sep 1; 2024 Sep 1. PMID: 39272908.
• Endothelial γ-protocadherins inhibit KLF2 and KLF4 to promote atherosclerosis.Joshi D, Coon BG, Chakraborty R, Deng H, Yang Z, Babar MU, Fernandez-Tussy P, Meredith E, Attanasio J, Joshi N, Traylor JG Jr, Orr AW, Fernandez-Hernando C, Libreros S, Schwartz MA. Nat Cardiovasc Res. 2024 Sep; 2024 Sep 4. PMID: 39232138.
• Stem cells tightly regulate dead cell clearance to maintain tissue fitness.Stewart KS, Abdusselamoglu MD, Tierney MT, Gola A, Hur YH, Gonzales KAU, Yuan S, Bonny AR, Yang Y, Infarinato NR, Cowley CJ, Levorse JM, Pasolli HA, Ghosh S, Rothlin CV, Fuchs E. Nature. 2024 Sep; 2024 Aug 21. PMID: 39169186.
• Author Correction: Mechanisms and clinical activity of an EGFR and HER2 exon 20-selective kinase inhibitor in non-small cell lung cancer.Robichaux JP, Elamin YY, Tan Z, Carter BW, Zhang S, Liu S, Li S, Chen T, Poteete A, Estrada-Bernal A, Le AT, Truini A, Nilsson MB, Sun H, Roarty E, Goldberg SB, Brahmer JR, Altan M, Lu C, Papadimitrakopoulou V, Politi K, Doebele RC, Wong KK, Heymach JV. Nat Med. 2024 Sep. PMID: 39164519.
• Controversy in mechanotransduction - the role of endothelial cell-cell junctions in fluid shear stress sensing.X S, Aitken C, Mehta V, Tardajos-Ayllon B, Serbanovic-Canic J, Zhu J, Miao B, Tzima E, Evans P, Fang Y, Schwartz MA. J Cell Sci. 2024 Sep 1; 2024 Sep 9. PMID: 39143856.
• Renalase peptides reduce pancreatitis severity in mice.Kolodecik TR, Guo X, Shugrue CA, Guo X, Desir GV, Wen L, Gorelick F. Am J Physiol Gastrointest Liver Physiol. 2024 Sep 1; 2024 Jul 16. PMID: 39010833.
• Quantitative Measurement of HER2 Expression in Non-Small Cell Lung Cancer With a High-Sensitivity Assay.Liu M, Vathiotis I, Robbins CJ, Chan NNN, Moutafi M, Burela S, Xirou V, Schalper KA, Herbst RS, Syrigos K, Rimm DL. Mod Pathol. 2024 Sep; 2024 Jul 2. PMID: 38964502.
• Deciphering spatial domains from spatial multi-omics with SpatialGlue.Long Y, Ang KS, Sethi R, Liao S, Heng Y, van Olst L, Ye S, Zhong C, Xu H, Zhang D, Kwok I, Husna N, Jian M, Ng LG, Chen A, Gascoigne NRJ, Gate D, Fan R, Xu X, Chen J. Nat Methods. 2024 Sep; 2024 Jun 21. PMID: 38907114.
• The development of hair follicles and nail.Lee SH, Platt S, Lim CH, Ito M, Myung P. Dev Biol. 2024 Sep; 2024 May 15. PMID: 38759942.
• Tau pathology is associated with synaptic density and longitudinal synaptic loss in Alzheimer's disease.Wang J, Huang Q, Chen X, You Z, He K, Guo Q, Huang Y, Yang Y, Lin Z, Guo T, Zhao J, Guan Y, Li B, Xie F. Mol Psychiatry. 2024 Sep; 2024 Apr 8. PMID: 38589563.
• BCAM (basal cell adhesion molecule) protein expression in different tumor populations.Burela S, He M, Trontzas IP, Gavrielatou N, Schalper KA, Langermann S, Flies DB, Rimm DL, Aung TN. Discov Oncol. 2024 Aug 29; 2024 Aug 29. PMID: 39207605.
• miR-33 deletion in hepatocytes attenuates MASLD-MASH-HCC progression.Fernández-Tussy P, Cardelo MP, Zhang H, Sun J, Price NL, Boutagy NE, Goedeke L, Cadena-Sandoval M, Xirouchaki CE, Brown W, Yang X, Pastor-Rojo O, Haeusler RA, Bennett AM, Tiganis T, Suárez Y, Fernández-Hernando C. JCI Insight. 2024 Aug 27; 2024 Aug 27. PMID: 39190492.
• Cellular stiffness sensing through talin 1 in tissue mechanical homeostasis.Chanduri M, Kumar A, Weiss D, Emuna N, Barsukov I, Shi M, Tanaka K, Wang X, Datye A, Kanyo J, Collin F, Lam T, Schwarz UD, Bai S, Nottoli T, Goult BT, Humphrey JD, Schwartz MA. Sci Adv. 2024 Aug 23; 2024 Aug 21. PMID: 39167642.
• Impact of Prior Chemotherapy on Response to Second-line Pembrolizumab in Urothelial Cancer: Exploratory Analysis of the Phase 3 KEYNOTE-045 Trial.de Wit R, Vaughn DJ, Fradet Y, Fong L, Climent MA, Necchi A, Petrylak DP, Gerritsen WR, Gurney H, Quinn DI, Culine S, Sternberg CN, Bajorin DF, Choueiri TK, Xu J, Imai K, Homet Moreno B, Bellmunt J, Lee JL. Eur Urol. 2024 Aug 21; 2024 Aug 21. PMID: 39174409.
• Glucose Challenge Uncovers Temporal Fungibility of Metabolic Homeostasis over a day:night cycle.Malik DM, Rhoades SD, Zhang SL, Sengupta A, Barber A, Haynes P, Arnadottir ES, Pack A, Kibbey RG, Kain P, Sehgal A, Weljie AM. bioRxiv. 2024 Aug 21; 2024 Aug 21. PMID: 37961230.
• Olfactory sensory neuron population expansions influence projection neuron adaptation and enhance odour tracking.Takagi S, Sancer G, Abuin L, Stupski SD, Roman Arguello J, Prieto-Godino LL, Stern DL, Cruchet S, Álvarez-Ocaña R, Wienecke CFR, van Breugel F, Jeanne JM, Auer TO, Benton R. Nat Commun. 2024 Aug 15; 2024 Aug 15. PMID: 39147786.