2014
Measurement of circulating tumor DNA as a cancer biomarker in gastrointestinal malignancies using a novel next-generation sequencing method.
James E, Narayan A, Stein S, Lacy J, Patel A, Hochster H. Measurement of circulating tumor DNA as a cancer biomarker in gastrointestinal malignancies using a novel next-generation sequencing method. Journal Of Clinical Oncology 2014, 32: 217-217. DOI: 10.1200/jco.2014.32.3_suppl.217.Peer-Reviewed Original ResearchGastrointestinal malignanciesMultiple time pointsTumor DNAAdvanced pancreatic cancerTime pointsCohort of patientsTumor DNA levelsChemo-radiation therapyMetastatic colon cancerAdjuvant settingCancer biomarkersMutant ctDNABevacizumab therapyTumor mutation profilesLiver metastasesGI tumorsGI cancersPancreatic cancerUltra-deep sequencingKRAS mutationsKRAS G12D mutationColon cancerAdditional longitudinal dataInformed consentLiquid biopsy
2012
Ultrasensitive Measurement of Hotspot Mutations in Tumor DNA in Blood Using Error-Suppressed Multiplexed Deep Sequencing
Narayan A, Carriero NJ, Gettinger SN, Kluytenaar J, Kozak KR, Yock TI, Muscato NE, Ugarelli P, Decker RH, Patel AA. Ultrasensitive Measurement of Hotspot Mutations in Tumor DNA in Blood Using Error-Suppressed Multiplexed Deep Sequencing. Cancer Research 2012, 72: 3492-3498. PMID: 22581825, PMCID: PMC3426449, DOI: 10.1158/0008-5472.can-11-4037.Peer-Reviewed Original ResearchConceptsNon-small cell lung cancerTumor DNATumor DNA levelsCell lung cancerCell-free tumor DNATreatment-associated changesDNA levelsTumor-specific mutationsPractical diagnostic testLung cancerPractical clinical implementationPatient samplesDiagnostic testsHotspot mutationsClinical implementationNext-generation sequencingBloodCancer biomarkersSuccessful useNormal DNAMutationsPatientsDeep sequencing