2024
Endovascular thrombectomy versus medical management for moderate-to-severe anterior cerebral artery occlusion stroke
Chen H, Khunte M, Malhotra A, Gandhi D, Colasurdo M. Endovascular thrombectomy versus medical management for moderate-to-severe anterior cerebral artery occlusion stroke. Journal Of Neurology 2024, 1-8. PMID: 39085619, DOI: 10.1007/s00415-024-12582-z.Peer-Reviewed Original ResearchAssociated with higher oddsAnterior cerebral arteryAssociated with higher ratesIntracranial hemorrhageEndovascular thrombectomyMedical managementHigher oddsEfficacy of endovascular thrombectomyFavorable short-term outcomesRetrospective cohort studyPatient selection criteriaShort-term outcomesEndovascular thrombectomy patientsIn-hospital mortalityMultivariate logistic regressionHome dischargeArtery occlusion strokeNational Inpatient SampleHigher ratesNeurological outcomeCohort studyPrimary outcomeCerebral arterySecondary outcomesOcclusion strokeThrombectomy vs Medical Management for Posterior Cerebral Artery Stroke: Systematic Review, Meta-Analysis, and Real-World Data.
Chen H, Khunte M, Colasurdo M, Malhotra A, Gandhi D. Thrombectomy vs Medical Management for Posterior Cerebral Artery Stroke: Systematic Review, Meta-Analysis, and Real-World Data. Neurology 2024, 102: e209315. PMID: 38626383, PMCID: PMC11175628, DOI: 10.1212/wnl.0000000000209315.Peer-Reviewed Original ResearchConceptsSymptomatic intracranial hemorrhagePosterior cerebral arteryAssociated with higher oddsNational Inpatient SampleEndovascular thrombectomyHigher oddsMedical managementCohort studyFunctional independencePosterior cerebral artery strokeSafety of endovascular thrombectomyOdds of symptomatic intracranial hemorrhageAssociated with significantly higher ratesOxford Centre for Evidence-Based Medicine criteriaRates of in-hospital mortalityCentre for Evidence-Based Medicine criteriaMeta-analysisRate of ICHAssociated with different oddsHigher odds of deathRate of subarachnoid hemorrhageIn-hospital mortalityAssociated with lower ratesClass III evidenceLevel of evidence
2023
Radiographic Signs of Advanced Cerebral Venous Thrombosis Negatively Modulate the Effectiveness of Endovascular Treatments
Chen H, Khunte M, Colasurdo M, Singh P, Malhotra A, Gandhi D. Radiographic Signs of Advanced Cerebral Venous Thrombosis Negatively Modulate the Effectiveness of Endovascular Treatments. Cerebrovascular Diseases 2023, 1-8. PMID: 37931607, DOI: 10.1159/000534821.Peer-Reviewed Original ResearchCerebral venous thrombosisGood discharge outcomeEndovascular treatmentRadiographic signsCVT patientsHospital mortalityVenous thrombosisDischarge outcomesMedical managementBetter outcomesSevere cerebral venous thrombosisNational Inpatient Sample databaseConservative medical managementPatient selection practicesPresence of infarctionShort-term effectivenessEVT patientsEVT treatmentParenchymal manifestationsMedical comorbiditiesMultivariable adjustmentCerebral infarctionPatient demographicsSecondary outcomesHospitalization outcomes
2020
CT Angiography for Triage of Patients with Acute Minor Stroke: A Cost-effectiveness Analysis.
Wu X, Hughes DR, Gandhi D, Matouk CC, Sheth K, Schindler J, Wira C, Wintermark M, Sanelli P, Malhotra A. CT Angiography for Triage of Patients with Acute Minor Stroke: A Cost-effectiveness Analysis. Radiology 2020, 294: 580-588. PMID: 31934828, DOI: 10.1148/radiol.2019191238.Peer-Reviewed Original ResearchConceptsLarge vessel occlusionAcute minor strokeBest medical managementMinor strokeCT angiographyMedical managementProbabilistic sensitivity analysesLower health benefitsImmediate thrombectomyHealth benefitsHealth outcomesVascular imagingAcute ischemic strokeMarkov decision-analytic modelWorse health outcomesImproved health outcomesDecision analytic modelNet monetary benefitIntravenous thrombolysisIschemic strokeYounger patientsThrombectomy strategyPatientsAngiographyStroke