2024
Thrombectomy vs Medical Management for Posterior Cerebral Artery Stroke: Systematic Review, Meta-Analysis, and Real-World Data.
Chen H, Khunte M, Colasurdo M, Malhotra A, Gandhi D. Thrombectomy vs Medical Management for Posterior Cerebral Artery Stroke: Systematic Review, Meta-Analysis, and Real-World Data. Neurology 2024, 102: e209315. PMID: 38626383, PMCID: PMC11175628, DOI: 10.1212/wnl.0000000000209315.Peer-Reviewed Original ResearchConceptsSymptomatic intracranial hemorrhagePosterior cerebral arteryAssociated with higher oddsNational Inpatient SampleEndovascular thrombectomyHigher oddsMedical managementCohort studyFunctional independencePosterior cerebral artery strokeSafety of endovascular thrombectomyOdds of symptomatic intracranial hemorrhageAssociated with significantly higher ratesOxford Centre for Evidence-Based Medicine criteriaRates of in-hospital mortalityCentre for Evidence-Based Medicine criteriaMeta-analysisRate of ICHAssociated with different oddsHigher odds of deathRate of subarachnoid hemorrhageIn-hospital mortalityAssociated with lower ratesClass III evidenceLevel of evidence
2023
Trends in Use of Intravenous Thrombolysis and Endovascular Thrombectomy in Patients With Acute Stroke With Large Vessel Occlusion 2016 to 2020 and Impact of COVID‐19 Pandemic
Khunte M, Chen H, Khunte A, Payabvash S, Gandhi D, Malhotra A. Trends in Use of Intravenous Thrombolysis and Endovascular Thrombectomy in Patients With Acute Stroke With Large Vessel Occlusion 2016 to 2020 and Impact of COVID‐19 Pandemic. Journal Of The American Heart Association 2023, 12: e029579. PMID: 37889182, PMCID: PMC10727381, DOI: 10.1161/jaha.122.029579.Peer-Reviewed Original ResearchIntravenous thrombolysis prior to endovascular thrombectomy in elderly stroke patients: An analysis of the National Inpatient Sample database
Chen H, Khunte M, Colasurdo M, Malhotra A, Gandhi D. Intravenous thrombolysis prior to endovascular thrombectomy in elderly stroke patients: An analysis of the National Inpatient Sample database. Journal Of The Neurological Sciences 2023, 454: 120842. PMID: 37856997, DOI: 10.1016/j.jns.2023.120842.Peer-Reviewed Original ResearchConceptsNational Inpatient Sample databaseHospital mortalityHemorrhagic complicationsIntravenous thrombolysisEndovascular thrombectomyEVT patientsIVT treatmentThrombectomy centreElderly patientsMultivariable logistic regression modelSample databaseStroke risk factorsElderly stroke patientsCross-sectional studyLarge-scale cross-sectional studyOutcomes of interestHigh rateLogistic regression modelsPatients 80Medical comorbiditiesOnly patientsPatient demographicsStroke etiologyThrombolytic treatmentHemorrhagic riskLetter to the Editor Re; "Treatment and outcomes of non-aneurysmal perimesencephalic subarachnoid hemorrhage: A 5 year retrospective study in a tertiary care centre"
Malhotra A. Letter to the Editor Re; "Treatment and outcomes of non-aneurysmal perimesencephalic subarachnoid hemorrhage: A 5 year retrospective study in a tertiary care centre". Clinical Neurology And Neurosurgery 2023, 233: 107937. PMID: 37591039, DOI: 10.1016/j.clineuro.2023.107937.Commentaries, Editorials and LettersLetter to the Editor Regarding “Drip and Ship versus Mothership Model in the MCA Stroke: A Propensity-Matched Real World Analysis Through NIS Data”
Malhotra A, Khunte M, Wu X, Radmard M. Letter to the Editor Regarding “Drip and Ship versus Mothership Model in the MCA Stroke: A Propensity-Matched Real World Analysis Through NIS Data”. World Neurosurgery 2023, 170: 266. PMID: 36782423, DOI: 10.1016/j.wneu.2022.09.098.Peer-Reviewed Original ResearchLetter to the Editor Re “Endovascular thrombectomy or bridging therapy in minor ischemic stroke with large vessel occlusion”
Malhotra A, Khunte M, Wu X, Radmard M. Letter to the Editor Re “Endovascular thrombectomy or bridging therapy in minor ischemic stroke with large vessel occlusion”. Thrombosis Research 2023, 232: 145. PMID: 36739257, DOI: 10.1016/j.thromres.2023.01.008.Peer-Reviewed Original Research
2022
Associations of Osteoarthritis With Thrombectomy Utilization and Outcomes for Large Vessel Acute Ischemic Stroke
Chen H, Khunte M, Colasurdo M, Jindal G, Malhotra A, Gandhi D, Chaturvedi S. Associations of Osteoarthritis With Thrombectomy Utilization and Outcomes for Large Vessel Acute Ischemic Stroke. Stroke 2022, 54: 518-526. PMID: 36541211, DOI: 10.1161/strokeaha.122.041749.Peer-Reviewed Original ResearchMeSH KeywordsAdultBrain IschemiaCross-Sectional StudiesEndovascular ProceduresHumansIschemic StrokeOsteoarthritisStrokeThrombectomyTreatment OutcomeConceptsMultivariable logistic regression modelEndovascular thrombectomyAssociation of osteoarthritisLogistic regression modelsHospital mortalityMedical comorbiditiesIschemic strokeRisk factorsLower oddsLarge vessel acute ischemic strokeNational Inpatient Sample databaseMultivariable logistic regression analysisLarge-vessel ischemic strokeIntravenous thrombolysis treatmentStroke risk factorsAcute ischemic strokeIschemic stroke patientsPresence of osteoarthritisCause of disabilityCross-sectional studyLogistic regression analysisPatient selection practicesLarge-scale cross-sectional studyDirect risk factorEVT treatmentLetter to the editor re “Minor stroke in large vessel occlusion: A matched analysis of patients from the German Stroke Registry—Endovascular Treatment and patients from the Safe Implementation of Treatments in Stroke—International Stroke Thrombolysis Register”
Malhotra A, Khunte M, Wu X, Radmard M. Letter to the editor re “Minor stroke in large vessel occlusion: A matched analysis of patients from the German Stroke Registry—Endovascular Treatment and patients from the Safe Implementation of Treatments in Stroke—International Stroke Thrombolysis Register”. European Journal Of Neurology 2022, 30: 290-291. PMID: 36260371, DOI: 10.1111/ene.15598.Commentaries, Editorials and LettersMeSH KeywordsBrain IschemiaEndovascular ProceduresHumansRegistriesStrokeThrombectomyThrombolytic TherapyTissue Plasminogen ActivatorTreatment Outcome
2020
Effects of Collateral Status on Infarct Distribution Following Endovascular Therapy in Large Vessel Occlusion Stroke
Al-Dasuqi K, Payabvash S, Torres-Flores GA, Strander SM, Nguyen CK, Peshwe KU, Kodali S, Silverman A, Malhotra A, Johnson MH, Matouk CC, Schindler JL, Sansing LH, Falcone GJ, Sheth KN, Petersen NH. Effects of Collateral Status on Infarct Distribution Following Endovascular Therapy in Large Vessel Occlusion Stroke. Stroke 2020, 51: e193-e202. PMID: 32781941, PMCID: PMC7484023, DOI: 10.1161/strokeaha.120.029892.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overArterial Occlusive DiseasesCerebral InfarctionCohort StudiesCollateral CirculationComputed Tomography AngiographyEndovascular ProceduresFemaleHumansInfarction, Middle Cerebral ArteryLinear ModelsMagnetic Resonance AngiographyMaleMiddle AgedReperfusionRetrospective StudiesStrokeThrombectomyTreatment OutcomeWhite MatterConceptsLarge vessel occlusion strokeFinal infarct volumeCollateral statusPoor collateral statusFavorable outcomeInfarct distributionInfarct volumeReperfusion successIndependent predictorsOcclusion strokeInternal capsuleAnterior circulation large vessel occlusion ischemic strokeLarge vessel occlusion ischemic strokeDeep white matter tractsBaseline collateral statusBorder-zone infarctionEarly favorable outcomeEarly functional outcomesRankin Scale scoreCohort of patientsDegree of reperfusionLarge vessel occlusionComputed tomography angiographyDeep white matterMagnetic resonance imagingPosterior Reversible Encephalopathy Syndrome Caused by Induced Hypertension to Treat Cerebral Vasospasm Secondary to Aneurysmal Subarachnoid Hemorrhage
Elsamadicy AA, Koo AB, Reeves BC, Sujijantarat N, David WB, Malhotra A, Gilmore EJ, Matouk CC, Hebert R. Posterior Reversible Encephalopathy Syndrome Caused by Induced Hypertension to Treat Cerebral Vasospasm Secondary to Aneurysmal Subarachnoid Hemorrhage. World Neurosurgery 2020, 143: e309-e323. PMID: 32721559, DOI: 10.1016/j.wneu.2020.07.135.Peer-Reviewed Original ResearchMeSH KeywordsFemaleHumansHypertensionMiddle AgedPosterior Leukoencephalopathy SyndromeSubarachnoid HemorrhageTreatment OutcomeVasospasm, IntracranialConceptsPosterior reversible encephalopathy syndromeSystolic blood pressure goalBlood pressure goalsReversible encephalopathy syndromeAneurysmal subarachnoid hemorrhageSubarachnoid hemorrhageEncephalopathy syndromeCerebral vasospasmClinical statusFluid-attenuated inversion recovery hyperintensityMiddle cerebral artery syndromeAcute-onset headachePossible ischemic eventsClinical examination findingsInversion recovery hyperintensityPatient's clinical statusTransient clinical improvementArtery aneurysm ruptureMiddle cerebral arteryLevel of arousalMagnetic resonance imagingDigital subtraction angiographyInduced hypertensionClinical improvementIschemic eventsReduced 2-year aneurysm retreatment and costs among patients treated with flow diversion versus non-flow diversion embolization: A Premier Healthcare Database retrospective cohort study
Grandhi R, Karsy M, Taussky P, Ricker CN, Malhotra A. Reduced 2-year aneurysm retreatment and costs among patients treated with flow diversion versus non-flow diversion embolization: A Premier Healthcare Database retrospective cohort study. PLOS ONE 2020, 15: e0234478. PMID: 32555657, PMCID: PMC7302520, DOI: 10.1371/journal.pone.0234478.Peer-Reviewed Original ResearchConceptsPipeline Embolization DeviceEndovascular treatmentRetreatment ratePS matchingIntracranial aneurysmsRetrospective cohort studyRate of readmissionEmergency department visitsLength of stayLower retreatment rateInitial treatment costsUnruptured intracranial aneurysmsPropensity-score matchingTime of treatmentCumulative followCohort studyReadmission costsDepartment visitsPatient subgroupsPED placementCase selection biasSame hospitalAneurysm retreatmentEmbolization DevicePatientsEndovascular Contact Aspiration versus Stent Retriever for Revascularization in Patients with Acute Ischemic Stroke and Large Vessel Occlusion: A Cost-Minimization Analysis
Malhotra A, Boltyenkov A, Wu X, Matouk CC, Forman HP, Gandhi D, Sanelli P. Endovascular Contact Aspiration versus Stent Retriever for Revascularization in Patients with Acute Ischemic Stroke and Large Vessel Occlusion: A Cost-Minimization Analysis. World Neurosurgery 2020, 139: e23-e31. PMID: 32105871, DOI: 10.1016/j.wneu.2020.02.078.Peer-Reviewed Original Research
2019
Comparative Effectiveness of Endovascular Thrombectomy in Elderly Stroke Patients
Malhotra A, Wu X, Payabvash S, Matouk CC, Forman HP, Gandhi D, Sanelli P, Schindler J. Comparative Effectiveness of Endovascular Thrombectomy in Elderly Stroke Patients. Stroke 2019, 50: 963-969. PMID: 30908156, DOI: 10.1161/strokeaha.119.025031.Peer-Reviewed Original ResearchMeSH KeywordsAged, 80 and overBrain IschemiaFemaleFibrinolytic AgentsHumansMaleStrokeThrombectomyTissue Plasminogen ActivatorTreatment OutcomeConceptsQuality-adjusted life yearsIntravenous thrombolysisEndovascular thrombectomyLarge vessel occlusionAge 80 yearsEVT strategyVessel occlusionModified Rankin Scale scorePoststroke functional outcomeAcute ischemic strokeRankin Scale scoreElderly stroke patientsMarkov decision-analytic modelYears of ageDecision analytic modelMultiple sensitivity analysesPurpose- StrokeAcute strokeBaseline disabilityElderly patientsIschemic strokeStroke patientsFunctional outcomeHealthy patientsAdvanced ageComparative effectiveness analysis of Pipeline device versus coiling in unruptured aneurysms smaller than 10 mm.
Malhotra A, Wu X, Miller T, Matouk CC, Sanelli P, Gandhi D. Comparative effectiveness analysis of Pipeline device versus coiling in unruptured aneurysms smaller than 10 mm. Journal Of Neurosurgery 2019, 132: 42-50. PMID: 30641830, DOI: 10.3171/2018.8.jns181080.Peer-Reviewed Original ResearchConceptsPipeline Embolization DeviceStent-assisted coilingRetreatment rateSmall unruptured aneurysmsComparative effectiveness analysisProbabilistic sensitivity analysesUnruptured aneurysmsEndovascular coilingHealth benefitsUse of PEDHigher health benefitsRate of recurrenceFavorable treatment strategyDecision-analytical studyStent-assisted techniquePED placementTreatment modalitiesEffectiveness analysisTreatment strategiesSmall aneurysmsEmbolization DeviceSimple coilingOutcome riskAneurysmsRetreatment
2018
Cost-Effectiveness Analysis of Intracapsular Tonsillectomy and Total Tonsillectomy for Pediatric Obstructive Sleep Apnea
Bagwell K, Wu X, Baum ED, Malhotra A. Cost-Effectiveness Analysis of Intracapsular Tonsillectomy and Total Tonsillectomy for Pediatric Obstructive Sleep Apnea. Applied Health Economics And Health Policy 2018, 16: 527-535. PMID: 29797301, DOI: 10.1007/s40258-018-0396-4.Peer-Reviewed Original ResearchConceptsProbabilistic sensitivity analysesIncremental cost-effectiveness ratioDeterministic sensitivity analysesMedicaid Services perspectiveResultsBase-case analysisCost-effectiveness analysisCost-effectiveness ratioSensitivity analysisBase-case analysisRelative cost effectivenessEconomic evaluationMedicare ValueDecision modelOSA recurrenceRevision tonsillectomyPartial intracapsular tonsillectomyDecision tree modelCost-effective strategyQALYCase analysisService perspectiveCostCost effectivenessConclusionStudy resultsDisutility
2015
Langerhans Cell Histiocytosis of the Temporal Bone with Otic Capsule Involvement
Blumberg JM, Malhotra A, Wu X, Virk RK, Kveton JF, Michaelides EM. Langerhans Cell Histiocytosis of the Temporal Bone with Otic Capsule Involvement. Clinical Neuroradiology 2015, 27: 163-168. PMID: 26341354, DOI: 10.1007/s00062-015-0461-4.Peer-Reviewed Original ResearchConceptsOtic capsule involvementLangerhans cell histiocytosisCases of LCHCapsule involvementTemporal boneCell histiocytosisMagnetic resonance imaging (MRI) scansMethodsWith institutional review board approvalOtic capsuleInstitutional review board approvalRetrospective case reviewTreatment of patientsResonance imaging scansReview board approvalComplete restorationPosttreatment imagingAudiologic findingsPosttreatment followDestructive lesionsInstitutional databaseHistologic diagnosisImaging scansCommon siteAppropriate treatmentAdequate treatmentConductive Hearing Loss and the Jugular Bulb
Toman J, Wu X, Malhotra A, Michaelides E. Conductive Hearing Loss and the Jugular Bulb. Clinical Neuroradiology 2015, 26: 235-238. PMID: 26187025, DOI: 10.1007/s00062-015-0436-5.Peer-Reviewed Original Research
2008
Simultaneous Gastric and Small Intestinal Trichobezoars
Malhotra A, Jones L, Drugas G. Simultaneous Gastric and Small Intestinal Trichobezoars. Pediatric Emergency Care 2008, 24: 774-776. PMID: 19018222, DOI: 10.1097/pec.0b013e31818c2891.Peer-Reviewed Original Research