2024
Automated detection of early signs of irreversible ischemic change on CTA source images in patients with large vessel occlusion
Mak A, Matouk C, Avery E, Behland J, Haider S, Frey D, Madai V, Vajkoczy P, Griessenauer C, Zand R, Hendrix P, Abedi V, Sanelli P, Falcone G, Petersen N, Sansing L, Sheth K, Payabvash S, Malhotra A. Automated detection of early signs of irreversible ischemic change on CTA source images in patients with large vessel occlusion. PLOS ONE 2024, 19: e0304962. PMID: 38870240, PMCID: PMC11175522, DOI: 10.1371/journal.pone.0304962.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overBrain IschemiaComputed Tomography AngiographyDiffusion Magnetic Resonance ImagingFemaleHumansIschemic StrokeMaleMiddle AgedRetrospective StudiesROC CurveStrokeConceptsDiffusion-weighted imagingLarge vessel occlusionIrreversible ischemic changesPoor functional outcomeFunctional outcomesIschemic changesInfarct volumeAlberta Stroke Program Early CT ScorePredicting poor functional outcomeVessel occlusionFollow-up diffusion-weighted imagingAnterior circulation LVO strokeCTA source imagesReceiver operating characteristic curveExpert human readersPredicting final infarctionASPECTS regionsAdmission CTANon-inferior performanceBaseline CTACT scoreFinal infarctEndovascular therapyHU attenuationValidation cohort
2023
Value Proposition of FDA-Approved Artificial Intelligence Algorithms for Neuroimaging
Bajaj S, Khunte M, Moily N, Payabvash S, Wintermark M, Gandhi D, Malhotra A. Value Proposition of FDA-Approved Artificial Intelligence Algorithms for Neuroimaging. Journal Of The American College Of Radiology 2023, 20: 1241-1249. PMID: 37574094, DOI: 10.1016/j.jacr.2023.06.034.Peer-Reviewed Original ResearchMeSH KeywordsAcademies and InstitutesAlgorithmsArtificial IntelligenceComputed Tomography AngiographyHumansNeuroimagingConceptsArtificial intelligence algorithmsAI algorithmsIntelligence algorithmsValue propositionUser timeAI developersMost vendorsProduct informationDevelopersAlgorithmVendorsProduct websitesDeveloper websitesWebsitesUser testimonialsCentral databaseTechnologyDatabaseInformationAIDevicesAdoptionPropositionCost
2020
Effects of Collateral Status on Infarct Distribution Following Endovascular Therapy in Large Vessel Occlusion Stroke
Al-Dasuqi K, Payabvash S, Torres-Flores GA, Strander SM, Nguyen CK, Peshwe KU, Kodali S, Silverman A, Malhotra A, Johnson MH, Matouk CC, Schindler JL, Sansing LH, Falcone GJ, Sheth KN, Petersen NH. Effects of Collateral Status on Infarct Distribution Following Endovascular Therapy in Large Vessel Occlusion Stroke. Stroke 2020, 51: e193-e202. PMID: 32781941, PMCID: PMC7484023, DOI: 10.1161/strokeaha.120.029892.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overArterial Occlusive DiseasesCerebral InfarctionCohort StudiesCollateral CirculationComputed Tomography AngiographyEndovascular ProceduresFemaleHumansInfarction, Middle Cerebral ArteryLinear ModelsMagnetic Resonance AngiographyMaleMiddle AgedReperfusionRetrospective StudiesStrokeThrombectomyTreatment OutcomeWhite MatterConceptsLarge vessel occlusion strokeFinal infarct volumeCollateral statusPoor collateral statusFavorable outcomeInfarct distributionInfarct volumeReperfusion successIndependent predictorsOcclusion strokeInternal capsuleAnterior circulation large vessel occlusion ischemic strokeLarge vessel occlusion ischemic strokeDeep white matter tractsBaseline collateral statusBorder-zone infarctionEarly favorable outcomeEarly functional outcomesRankin Scale scoreCohort of patientsDegree of reperfusionLarge vessel occlusionComputed tomography angiographyDeep white matterMagnetic resonance imagingCT Angiography for Triage of Patients with Acute Minor Stroke: A Cost-effectiveness Analysis.
Wu X, Hughes DR, Gandhi D, Matouk CC, Sheth K, Schindler J, Wira C, Wintermark M, Sanelli P, Malhotra A. CT Angiography for Triage of Patients with Acute Minor Stroke: A Cost-effectiveness Analysis. Radiology 2020, 294: 580-588. PMID: 31934828, DOI: 10.1148/radiol.2019191238.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overComputed Tomography AngiographyCost-Benefit AnalysisHumansMiddle AgedStrokeTriageConceptsLarge vessel occlusionAcute minor strokeBest medical managementMinor strokeCT angiographyMedical managementProbabilistic sensitivity analysesLower health benefitsImmediate thrombectomyHealth benefitsHealth outcomesVascular imagingAcute ischemic strokeMarkov decision-analytic modelWorse health outcomesImproved health outcomesDecision analytic modelNet monetary benefitIntravenous thrombolysisIschemic strokeYounger patientsThrombectomy strategyPatientsAngiographyStroke
2019
Screening for Intracranial Aneurysms in Patients with Thoracic Aortic Aneurysms
Malhotra A, Seifert K, Wu X, Matouk C, Elefteriades JA. Screening for Intracranial Aneurysms in Patients with Thoracic Aortic Aneurysms. Cerebrovascular Diseases 2019, 47: 253-259. PMID: 31412341, DOI: 10.1159/000501194.Peer-Reviewed Original ResearchConceptsPrevalence of IAsThoracic aortic aneurysmIntracranial aneurysmsRetrospective studyAortic aneurysmRisk factorsPrevious retrospective studySignificant risk factorsPotential risk factorsMagnetic resonance angiogramStudent's t-testPatient demographicsUnivariate analysisHigh prevalenceLarge cohortGeneral populationPatientsAneurysmsPrevalenceCategorical variablesΧ2 testHypertensionT-testContinuous variablesIA locationCost-Effectiveness of Computed Tomography Angiography in Management of Tiny Unruptured Intracranial Aneurysms in the United States
Wu X, Matouk CC, Mangla R, Forman HP, Gandhi D, Sanelli P, Malhotra A. Cost-Effectiveness of Computed Tomography Angiography in Management of Tiny Unruptured Intracranial Aneurysms in the United States. Stroke 2019, 50: 2396-2403. PMID: 31340732, DOI: 10.1161/strokeaha.119.025600.Peer-Reviewed Original ResearchMeSH KeywordsAdultComputed Tomography AngiographyCost-Benefit AnalysisDisease ManagementFemaleFollow-Up StudiesHumansIntracranial AneurysmMaleMiddle AgedUnited StatesConceptsComputed tomography angiographyUnruptured intracranial aneurysmsIntracranial aneurysmsTomography angiographyCancer riskCTA surveillanceCost-effective strategyRadiation-induced brain tumorsRadiation-induced cancer riskSubsequent magnetic resonanceBrain cancer riskBetter health outcomesAnnual rupture riskProbabilistic sensitivity analysesRupture riskLower healthcare spendingAggressive managementPatients 30Subarachnoid hemorrhageIncidental detectionPrior historyHigh riskBrain tumorsAneurysmsHealth outcomesLetter by Malhotra and Wu Regarding Article, “Computed Tomography Angiography Versus Digital Subtraction Angiography for Postclipping Aneurysm Obliteration Detection: A Meta-Analysis”
Malhotra A, Wu X. Letter by Malhotra and Wu Regarding Article, “Computed Tomography Angiography Versus Digital Subtraction Angiography for Postclipping Aneurysm Obliteration Detection: A Meta-Analysis”. Stroke 2019, 50: e158. PMID: 31104622, DOI: 10.1161/strokeaha.119.025082.Peer-Reviewed Original ResearchMeSH KeywordsAneurysmAngiography, Digital SubtractionCerebral AngiographyComputed Tomography AngiographyHumansTomography, X-Ray Computed
2018
Letter to the editor regarding “Utility of CT angiography in screening for traumatic cerebrovascular injury”
Malhotra A, Wu X, Seifert K, Tu LH. Letter to the editor regarding “Utility of CT angiography in screening for traumatic cerebrovascular injury”. Clinical Neurology And Neurosurgery 2018, 176: 138. PMID: 30446415, DOI: 10.1016/j.clineuro.2018.11.003.Peer-Reviewed Original ResearchLetter to the Editor. Computed tomography angiography for the diagnosis of blunt cerebrovascular injury.
Malhotra A, Wu X, Tu L, Seifert K. Letter to the Editor. Computed tomography angiography for the diagnosis of blunt cerebrovascular injury. Journal Of Neurosurgery 2018, 129: 265-267. PMID: 29749913, DOI: 10.3171/2017.11.jns172884.Peer-Reviewed Original ResearchLetter to the Editor Regarding “Yield of Computed Tomography (CT) Angiography in Patients with Acute Headache, Normal Neurological Examination, and Normal Non Contrast CT: A Meta-Analysis”
Malhotra A, Wu X, Seifert K, Tu L. Letter to the Editor Regarding “Yield of Computed Tomography (CT) Angiography in Patients with Acute Headache, Normal Neurological Examination, and Normal Non Contrast CT: A Meta-Analysis”. Journal Of Stroke And Cerebrovascular Diseases 2018, 27: 2043. PMID: 29571755, DOI: 10.1016/j.jstrokecerebrovasdis.2018.02.049.Peer-Reviewed Original ResearchMeSH KeywordsAngiographyComputed Tomography AngiographyHeadacheHumansNeurologic ExaminationTomography, X-Ray Computed
2017
Letter to the Editor. Biffl Scale for blunt traumatic cerebrovascular injury.
Wu X, Malhotra A. Letter to the Editor. Biffl Scale for blunt traumatic cerebrovascular injury. Journal Of Neurosurgery 2017, 127: 707-708. PMID: 28686115, DOI: 10.3171/2017.1.jns1754.Peer-Reviewed Original ResearchAngiographyCerebrovascular TraumaComputed Tomography AngiographyHumansReproducibility of ResultsWounds, Nonpenetrating
2016
The Use of High-Risk Criteria in Screening Patients for Blunt Cerebrovascular Injury A Survey
Wu X, Malhotra A, Forman HP, Nunez D, Sanelli P. The Use of High-Risk Criteria in Screening Patients for Blunt Cerebrovascular Injury A Survey. Academic Radiology 2016, 24: 456-461. PMID: 27979639, DOI: 10.1016/j.acra.2016.11.010.Peer-Reviewed Original ResearchMeSH KeywordsAttitude of Health PersonnelCerebral AngiographyCerebrovascular TraumaComputed Tomography AngiographyDatabases, FactualDelayed DiagnosisEmergency Service, HospitalHumansMagnetic Resonance AngiographyMass ScreeningRadiologistsRisk AssessmentRisk FactorsSurveys and QuestionnairesUnited StatesWounds, NonpenetratingConceptsBlunt cerebrovascular injuryRisk factorsEmergency departmentCT angiographyDenver criteriaMR angiographyC1-C3 fracturesUtilization of imagingCerebrovascular injuryBlunt injuryBlunt traumaScreening ratesAngiographic studiesLarge academic institutionVascular injuryScreening patientsPatientsPreferred modalityRoutine useInjurySubsequent strokeAngiographyScreening criteriaPhysiciansRadiologistsLetter to the Editor: Screening protocol for blunt cerebrovascular injury.
Wu X, Durand D, Kalra VB, Liu R, Malhotra A. Letter to the Editor: Screening protocol for blunt cerebrovascular injury. Journal Of Neurosurgery 2016, 126: 1366-1367. PMID: 27834598, DOI: 10.3171/2016.8.jns161942.Peer-Reviewed Original ResearchLetter by Wu et al Regarding Article, “Safety of Computed Tomographic Angiography in the Evaluation of Patients With Acute Stroke
Wu X, Tu L, Malhotra A. Letter by Wu et al Regarding Article, “Safety of Computed Tomographic Angiography in the Evaluation of Patients With Acute Stroke. Stroke 2016, 47: e257. PMID: 27703091, DOI: 10.1161/strokeaha.116.014979.Peer-Reviewed Original ResearchCost-effectiveness analysis of CTA and LP for evaluation of suspected SAH after negative non-contrast CT
Wu X, Kalra VB, Forman HP, Malhotra A. Cost-effectiveness analysis of CTA and LP for evaluation of suspected SAH after negative non-contrast CT. Clinical Neurology And Neurosurgery 2016, 142: 104-111. PMID: 26827168, DOI: 10.1016/j.clineuro.2015.12.021.Peer-Reviewed Original Research