2021
KDM5B promotes immune evasion by recruiting SETDB1 to silence retroelements
Zhang SM, Cai WL, Liu X, Thakral D, Luo J, Chan LH, McGeary MK, Song E, Blenman KRM, Micevic G, Jessel S, Zhang Y, Yin M, Booth CJ, Jilaveanu LB, Damsky W, Sznol M, Kluger HM, Iwasaki A, Bosenberg MW, Yan Q. KDM5B promotes immune evasion by recruiting SETDB1 to silence retroelements. Nature 2021, 598: 682-687. PMID: 34671158, PMCID: PMC8555464, DOI: 10.1038/s41586-021-03994-2.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell Line, TumorDNA-Binding ProteinsEpigenesis, GeneticGene SilencingHeterochromatinHistone-Lysine N-MethyltransferaseHumansInterferon Type IJumonji Domain-Containing Histone DemethylasesMaleMelanomaMiceMice, Inbred C57BLMice, KnockoutNuclear ProteinsRepressor ProteinsRetroelementsTumor EscapeConceptsImmune checkpoint blockadeImmune evasionCheckpoint blockadeImmune responseAnti-tumor immune responseRobust adaptive immune responseTumor immune evasionAnti-tumor immunityAdaptive immune responsesType I interferon responseDNA-sensing pathwayMouse melanoma modelImmunotherapy resistanceMost patientsCurrent immunotherapiesTumor immunogenicityImmune memoryMelanoma modelCytosolic RNA sensingRole of KDM5BConsiderable efficacyInterferon responseImmunotherapyEpigenetic therapyBlockade
2020
Seasonality of Respiratory Viral Infections
Moriyama M, Hugentobler WJ, Iwasaki A. Seasonality of Respiratory Viral Infections. Annual Review Of Virology 2020, 7: 1-19. PMID: 32196426, DOI: 10.1146/annurev-virology-012420-022445.Peer-Reviewed Original ResearchMeSH KeywordsBetacoronavirusCoronavirus InfectionsCOVID-19HumansHumidityInfectious Disease Incubation PeriodInfluenza, HumanOrthomyxoviridaePandemicsPicornaviridae InfectionsPneumonia, ViralRespiratory Tract InfectionsRhinovirusSARS-CoV-2SeasonsSevere Acute Respiratory SyndromeSevere acute respiratory syndrome-related coronavirusSeverity of Illness IndexTemperatureConceptsRespiratory viral infectionsViral infectionSevere acute respiratory syndrome coronavirusAcute respiratory syndrome coronavirusViral respiratory infectionsAdaptive immune responsesRespiratory viral diseasesRespiratory infectionsRespiratory virusesInfluenza diseaseRespiratory tractImmune responseAnnual epidemicsHost responseInfectionMajor contributing factorViral diseasesDiseaseContributing factorVirus stabilityVirusEpidemicRecent studiesYearsHuman population
2018
KDM5 histone demethylases repress immune response via suppression of STING
Wu L, Cao J, Cai WL, Lang SM, Horton JR, Jansen DJ, Liu ZZ, Chen JF, Zhang M, Mott BT, Pohida K, Rai G, Kales SC, Henderson MJ, Hu X, Jadhav A, Maloney DJ, Simeonov A, Zhu S, Iwasaki A, Hall MD, Cheng X, Shadel GS, Yan Q. KDM5 histone demethylases repress immune response via suppression of STING. PLOS Biology 2018, 16: e2006134. PMID: 30080846, PMCID: PMC6095604, DOI: 10.1371/journal.pbio.2006134.Peer-Reviewed Original ResearchConceptsImmune responseSTING expressionCyclic GMP-AMP synthase stimulatorSuppression of STINGCancer cellsCancer immunotherapy agentsHuman papilloma virusAdaptive immune responsesMultiple clinical trialsExpression of STINGBreast cancer cellsInnate immune defenseRobust interferon responseMultiple cancer typesIntratumoral CD8Immunotherapy agentsAnticancer immunotherapyPatient survivalNeck cancerPapilloma virusClinical trialsT cellsSTING agonistsKDM5 histonePositive head
2014
Innate immunity to influenza virus infection
Iwasaki A, Pillai PS. Innate immunity to influenza virus infection. Nature Reviews Immunology 2014, 14: 315-328. PMID: 24762827, PMCID: PMC4104278, DOI: 10.1038/nri3665.Peer-Reviewed Original ResearchConceptsInfluenza virus infectionToll-like receptor 7T cell responsesVirus infectionInterferon-stimulated genesIL-1βNLRP3 inflammasomeViral challengeB cellsCell responsesHigh-dose viral challengeInfluenza virusAntiviral B cellsMultiple pattern recognition receptorsPlasmacytoid dendritic cellsAdaptive immune responsesInfected cellsRetinoic acid-inducible gene IAirway epithelial cellsAcid-inducible gene IPattern recognition receptorsInfluenza virus-infected cellsVirus-infected cellsAntiviral defense genesDendritic cells
2013
Innate immunity
Iwasaki A, Peiris M. Innate immunity. 2013, 267-282. DOI: 10.1002/9781118636817.ch17.Peer-Reviewed Original ResearchToll-like receptorsNOD-like receptorsImmune responseVirus infectionInfluenza virusHundreds of IFNProtective host responseInfluenza virus infectionAdaptive immune responsesInnate immune responseType I IFNInfluenza virus replicationInnate immune systemDendritic cellsNK cellsInfluenza infectionIL-1βInnate sensorsAdaptive immunityLike receptorsDetrimental pathologyI IFNAlveolar macrophagesHost responseImmune systemNitric Oxide and TNFα Are Critical Regulators of Reversible Lymph Node Vascular Remodeling and Adaptive Immune Response
Sellers SL, Iwasaki A, Payne GW. Nitric Oxide and TNFα Are Critical Regulators of Reversible Lymph Node Vascular Remodeling and Adaptive Immune Response. PLOS ONE 2013, 8: e60741. PMID: 23573281, PMCID: PMC3616017, DOI: 10.1371/journal.pone.0060741.Peer-Reviewed Original ResearchMeSH KeywordsAdaptive ImmunityAnimalsArteriolesCell DegranulationChlorocebus aethiopsFemaleHerpes SimplexLymph NodesMast CellsMiceMice, 129 StrainMice, Inbred C57BLMice, KnockoutNeovascularization, PhysiologicNG-Nitroarginine Methyl EsterNifedipineNitric OxideNitric Oxide Synthase Type IIIPhenylephrineTumor Necrosis Factor-alphaVasoconstrictionVasodilator AgentsVero CellsConceptsAdaptive immune responsesEndothelial nitric oxide synthaseImmune responseVascular remodelingHerpes simplex type II infectionT cell-dependent mechanismGenetic ablation modelCell-dependent mechanismNitric oxide levelsType II infectionNitric oxide synthaseCourse of infectionInguinal LNsLN cellularityVascular eventsVascular changesArteriole diameterPharmacological blockadeMain arterioleOxide synthaseTNFα expressionMast cellsOxide levelsViral infectionIntravital microscopy
2011
Control of antiviral immunity by pattern recognition and the microbiome
Pang IK, Iwasaki A. Control of antiviral immunity by pattern recognition and the microbiome. Immunological Reviews 2011, 245: 209-226. PMID: 22168422, PMCID: PMC3659816, DOI: 10.1111/j.1600-065x.2011.01073.x.Peer-Reviewed Original ResearchConceptsAdaptive immunityInnate pattern recognition receptorsChronic viral infectionsAdaptive immune responsesExtra-intestinal infectionsHost immune systemPattern recognition receptorsTransduce signalsImmune activationAutoimmune diseasesProbiotic therapyMammalian hostsImmune responseAntiviral immunityViral infectionMucosal surfacesViral recognitionImmune systemInvasive microbesProper developmentMicrobial sensingResident microbiotaInnate defenseSuch diseasesHost susceptibility
2010
Regulation of Adaptive Immunity by the Innate Immune System
Iwasaki A, Medzhitov R. Regulation of Adaptive Immunity by the Innate Immune System. Science 2010, 327: 291-295. PMID: 20075244, PMCID: PMC3645875, DOI: 10.1126/science.1183021.Peer-Reviewed Original ResearchConceptsInnate immune recognitionB lymphocyte-mediated immune responsesImmune responsePattern recognition receptorsImmune recognitionAntigen-specific adaptive immune responsesLymphocyte-mediated immune responsesMicrobial pathogensInnate immune systemAdaptive immune responsesRecognition receptorsHost defenseField of immunologyAdaptive immunityImmune systemFundamental questionsReceptorsRegulationPathwayPathogensInvasionDefenseInjuryInfectionDiscovery
2009
Inflammasome recognition of influenza virus is essential for adaptive immune responses
Ichinohe T, Lee HK, Ogura Y, Flavell R, Iwasaki A. Inflammasome recognition of influenza virus is essential for adaptive immune responses. Journal Of Experimental Medicine 2009, 206: 79-87. PMID: 19139171, PMCID: PMC2626661, DOI: 10.1084/jem.20081667.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibody FormationApoptosis Regulatory ProteinsCalcium-Binding ProteinsCARD Signaling Adaptor ProteinsCarrier ProteinsCaspase 1CD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCell MovementCytoskeletal ProteinsDendritic CellsImmunity, CellularImmunity, InnateImmunoglobulin IsotypesInterleukin-1betaLungMacrophages, AlveolarMiceMice, Inbred C57BLMice, KnockoutMultiprotein ComplexesNasal Lavage FluidNLR Family, Pyrin Domain-Containing 3 ProteinOrthomyxoviridaeOrthomyxoviridae InfectionsReceptors, Interleukin-1Survival AnalysisConceptsInfluenza virus infectionNOD-like receptorsInfluenza virusVirus infectionAdaptive immunityInflammasome activationRetinoic acid-inducible gene I.CD8 T cell responsesCaspase-1Influenza virus resultsMucosal IgA secretionProtective antiviral immunitySystemic IgG responseCD4 T cellsT cell responsesAdaptive immune responsesType I interferonInnate immune systemRespiratory infectionsIgG responsesProtective immunityTLR signalsIgA secretionReceptor 7T cells
2007
Toll-like receptors regulation of viral infection and disease
Thompson JM, Iwasaki A. Toll-like receptors regulation of viral infection and disease. Advanced Drug Delivery Reviews 2007, 60: 786-794. PMID: 18280610, PMCID: PMC2410298, DOI: 10.1016/j.addr.2007.11.003.Peer-Reviewed Original ResearchConceptsToll-like receptorsVirus infectionRole of TLRsProtective anti-viral immunityToll-like receptor regulationAdaptive immune responsesAnti-viral immunityMammalian Toll-like receptorsVirus-induced diseaseViral nucleic acidsStudies of miceTLR activationInteraction of virusImmune responseViral infectionTLR systemTLR proteinsReceptor regulationInfectionDiseaseOutcomesCritical roleMiceImmunityReceptorsInnate control of adaptive immunity: Dendritic cells and beyond
Lee HK, Iwasaki A. Innate control of adaptive immunity: Dendritic cells and beyond. Seminars In Immunology 2007, 19: 48-55. PMID: 17276695, DOI: 10.1016/j.smim.2006.12.001.Peer-Reviewed Original ResearchConceptsDendritic cellsAdaptive immune responsesImmune responseInnate immune recognitionKey cell typesCell typesEffector cellsNaïve lymphocytesAdaptive immunityInnate controlImmune recognitionAnatomical locationImmediate defensePathogen triggersCellsRecent understandingLymphocytesInfectionImmunityResponse
2004
Toll-like receptor control of the adaptive immune responses
Iwasaki A, Medzhitov R. Toll-like receptor control of the adaptive immune responses. Nature Immunology 2004, 5: 987-995. PMID: 15454922, DOI: 10.1038/ni1112.Peer-Reviewed Original ResearchConceptsToll-like receptorsAdaptive immune responsesImmune responseMechanisms of TLRToll-like receptor controlHost defense responsesDendritic cell functionDendritic cell populationsMicrobial infectionsInnate immune systemDistinct anatomical locationsInflammatory reactionAdaptive immunityImmune systemAnatomical locationReceptor controlCell functionCell populationsMultiple mechanismsInfectionRecent studiesResponseInitiationSystemic defenseImportant clues