2010
In Vivo Requirement for Atg5 in Antigen Presentation by Dendritic Cells
Lee HK, Mattei LM, Steinberg BE, Alberts P, Lee YH, Chervonsky A, Mizushima N, Grinstein S, Iwasaki A. In Vivo Requirement for Atg5 in Antigen Presentation by Dendritic Cells. Immunity 2010, 32: 227-239. PMID: 20171125, PMCID: PMC2996467, DOI: 10.1016/j.immuni.2009.12.006.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigen PresentationAutophagy-Related Protein 5Cells, CulturedDendritic CellsFemaleHerpes SimplexHerpesvirus 2, HumanHistocompatibility Antigens Class IILymphocyte ActivationMiceMice, Inbred C57BLMice, KnockoutMicrotubule-Associated ProteinsRadiation ChimeraRNA, Small InterferingConceptsMHC-II presentationMHC class IIDendritic cellsAntigen presentationClass IIHerpes simplex virus infectionToll-like receptor stimuliT cell primingSimplex virus infectionCell primingAbsence of ATG5Microbial antigensVirus infectionMHC ICytosolic antigensConditional deletionAntigenReceptor stimuliAutophagic machineryKey autophagy genesRapid diseasePresentationATG5Lysosome fusionAutophagy genes
2009
Autophagy and Innate Recognition Systems
Tal MC, Iwasaki A. Autophagy and Innate Recognition Systems. Current Topics In Microbiology And Immunology 2009, 335: 107-121. PMID: 19802562, DOI: 10.1007/978-3-642-00302-8_5.Peer-Reviewed Original ResearchConceptsAutophagic machineryInnate immune systemDouble-membrane structureViral replication complexProcess of autophagyImportant physiological processesInduction of autophagyInnate recognition systemsCellular homeostasisReplication complexPattern recognition receptorsAutophagy pathwayLysosomal degradationPhysiological processesCytosolic constituentsEfficient phagocytosisInnate pattern recognition receptorsRNA virusesAutophagyCytosolic sensorsKey moleculesExtracellular pathogensRecognition receptorsImmune systemViral sensors