2022
Glycan-specific B-1 cells mediate blockade of endogenous retroviruses emergence through recognition of conserved glycan epitopes
Yang Y, Treger R, Hernandez-Bird J, Iwasaki A. Glycan-specific B-1 cells mediate blockade of endogenous retroviruses emergence through recognition of conserved glycan epitopes. The Journal Of Immunology 2022, 208: 126.31-126.31. DOI: 10.4049/jimmunol.208.supp.126.31.Peer-Reviewed Original ResearchB-1 cellsB cell populationsB cellsEndogenous retrovirusesCell-intrinsic controlNatural antibodiesImmunodeficient miceUnimmunized miceGlycan-specific antibodiesClonal repertoirePleural cavityRepertoire profilingViral antigensBlockadeComplement pathwayVH genesCell compartmentAntibodiesGlycan epitopesMiceRetrovirusesAbstract Endogenous retrovirusesEpitopesSensor stimulationCells
2021
Intranasal priming induces local lung-resident B cell populations that secrete protective mucosal antiviral IgA
Oh JE, Song E, Moriyama M, Wong P, Zhang S, Jiang R, Strohmeier S, Kleinstein SH, Krammer F, Iwasaki A. Intranasal priming induces local lung-resident B cell populations that secrete protective mucosal antiviral IgA. Science Immunology 2021, 6: eabj5129. PMID: 34890255, PMCID: PMC8762609, DOI: 10.1126/sciimmunol.abj5129.Peer-Reviewed Original ResearchConceptsVirus infectionIgA secretionB cellsMucosal surfacesIgA-secreting B cellsIgA-expressing cellsRole of IgARespiratory virus infectionsIgA-secreting cellsLower respiratory tractInfluenza virus infectionEffective immune protectionHeterologous virus infectionMemory B cellsSecretory immunoglobulin AProtein-based vaccinesB cell populationsPredominant Ig isotypeSite of entryIntranasal primingBronchoalveolar spaceProtective immunityVaccine strategiesRespiratory mucosaImmune protectionB cells join T cell clusters in the host response to recurrent herpes simplex virus 2 infection
Gehlhausen JR, Iwasaki A. B cells join T cell clusters in the host response to recurrent herpes simplex virus 2 infection. Journal Of Clinical Investigation 2021, 131: e148300. PMID: 33938452, PMCID: PMC8087191, DOI: 10.1172/jci148300.Peer-Reviewed Original ResearchConceptsAntibody-secreting cellsB cellsRecurrent lesionsHerpes simplex virus 2 infectionHSV-2-specific antibodiesRecurrent genital herpes lesionsSimplex virus 2 infectionGenital herpes lesionsHSV-2 lesionsVirus 2 infectionT cell clustersSkin biopsy specimensB cell subsetsB cell populationsNaive B cellsStage of infectionLesion reactivationDisease resolutionImmune infiltratesAntibody levelsHerpes lesionsCell subsetsBiopsy specimensHost responseLesionsGlycan-reactive natural antibodies mediate blockade of endogenous retroviruses emergence
Yang Y, Treger R, Hernandez-Bird J, Iwasaki A. Glycan-reactive natural antibodies mediate blockade of endogenous retroviruses emergence. The Journal Of Immunology 2021, 206: 114.09-114.09. DOI: 10.4049/jimmunol.206.supp.114.09.Peer-Reviewed Original ResearchB-1 cellsB cell populationsB cellsNatural antibodiesEndogenous retrovirusesCell-intrinsic controlImmunodeficient miceSelf-antigensUnimmunized miceFetal haematopoiesisGlycan-specific antibodiesClonal repertoirePleural cavityRepertoire profilingViral antigensBlockadeComplement pathwayVH genesCell compartmentAntibodiesCell-specificAbstract Endogenous retrovirusesMiceGenetic invadersVertebrate genomes