2022
Glycan-specific B-1 cells mediate blockade of endogenous retroviruses emergence through recognition of conserved glycan epitopes
Yang Y, Treger R, Hernandez-Bird J, Iwasaki A. Glycan-specific B-1 cells mediate blockade of endogenous retroviruses emergence through recognition of conserved glycan epitopes. The Journal Of Immunology 2022, 208: 126.31-126.31. DOI: 10.4049/jimmunol.208.supp.126.31.Peer-Reviewed Original ResearchB-1 cellsB cell populationsB cellsEndogenous retrovirusesCell-intrinsic controlNatural antibodiesImmunodeficient miceUnimmunized miceGlycan-specific antibodiesClonal repertoirePleural cavityRepertoire profilingViral antigensBlockadeComplement pathwayVH genesCell compartmentAntibodiesGlycan epitopesMiceRetrovirusesAbstract Endogenous retrovirusesEpitopesSensor stimulationCells
2021
KDM5B promotes immune evasion by recruiting SETDB1 to silence retroelements
Zhang SM, Cai WL, Liu X, Thakral D, Luo J, Chan LH, McGeary MK, Song E, Blenman KRM, Micevic G, Jessel S, Zhang Y, Yin M, Booth CJ, Jilaveanu LB, Damsky W, Sznol M, Kluger HM, Iwasaki A, Bosenberg MW, Yan Q. KDM5B promotes immune evasion by recruiting SETDB1 to silence retroelements. Nature 2021, 598: 682-687. PMID: 34671158, PMCID: PMC8555464, DOI: 10.1038/s41586-021-03994-2.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell Line, TumorDNA-Binding ProteinsEpigenesis, GeneticGene SilencingHeterochromatinHistone-Lysine N-MethyltransferaseHumansInterferon Type IJumonji Domain-Containing Histone DemethylasesMaleMelanomaMiceMice, Inbred C57BLMice, KnockoutNuclear ProteinsRepressor ProteinsRetroelementsTumor EscapeConceptsImmune checkpoint blockadeImmune evasionCheckpoint blockadeImmune responseAnti-tumor immune responseRobust adaptive immune responseTumor immune evasionAnti-tumor immunityAdaptive immune responsesType I interferon responseDNA-sensing pathwayMouse melanoma modelImmunotherapy resistanceMost patientsCurrent immunotherapiesTumor immunogenicityImmune memoryMelanoma modelCytosolic RNA sensingRole of KDM5BConsiderable efficacyInterferon responseImmunotherapyEpigenetic therapyBlockadeGlycan-reactive natural antibodies mediate blockade of endogenous retroviruses emergence
Yang Y, Treger R, Hernandez-Bird J, Iwasaki A. Glycan-reactive natural antibodies mediate blockade of endogenous retroviruses emergence. The Journal Of Immunology 2021, 206: 114.09-114.09. DOI: 10.4049/jimmunol.206.supp.114.09.Peer-Reviewed Original ResearchB-1 cellsB cell populationsB cellsNatural antibodiesEndogenous retrovirusesCell-intrinsic controlImmunodeficient miceSelf-antigensUnimmunized miceFetal haematopoiesisGlycan-specific antibodiesClonal repertoirePleural cavityRepertoire profilingViral antigensBlockadeComplement pathwayVH genesCell compartmentAntibodiesCell-specificAbstract Endogenous retrovirusesMiceGenetic invadersVertebrate genomes