2010
In Vivo Requirement for Atg5 in Antigen Presentation by Dendritic Cells
Lee HK, Mattei LM, Steinberg BE, Alberts P, Lee YH, Chervonsky A, Mizushima N, Grinstein S, Iwasaki A. In Vivo Requirement for Atg5 in Antigen Presentation by Dendritic Cells. Immunity 2010, 32: 227-239. PMID: 20171125, PMCID: PMC2996467, DOI: 10.1016/j.immuni.2009.12.006.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigen PresentationAutophagy-Related Protein 5Cells, CulturedDendritic CellsFemaleHerpes SimplexHerpesvirus 2, HumanHistocompatibility Antigens Class IILymphocyte ActivationMiceMice, Inbred C57BLMice, KnockoutMicrotubule-Associated ProteinsRadiation ChimeraRNA, Small InterferingConceptsMHC-II presentationMHC class IIDendritic cellsAntigen presentationClass IIHerpes simplex virus infectionToll-like receptor stimuliT cell primingSimplex virus infectionCell primingAbsence of ATG5Microbial antigensVirus infectionMHC ICytosolic antigensConditional deletionAntigenReceptor stimuliAutophagic machineryKey autophagy genesRapid diseasePresentationATG5Lysosome fusionAutophagy genes
2008
In vivo requirement for autophagy in antigen presentation by dendritic cells
LEE H, Lee Y, Chervonsky A, Mizushima N, Iwasaki A. In vivo requirement for autophagy in antigen presentation by dendritic cells. The FASEB Journal 2008, 22: 1068.13-1068.13. DOI: 10.1096/fasebj.22.1_supplement.1068.13.Peer-Reviewed Original ResearchCD4 T cellsCD4 T cell responsesT cell responsesDendritic cellsAntigen presentationT cellsMajor histocompatibility complexCell responsesFetal liver chimeric miceClass II major histocompatibility complexLiver chimeric miceDegradation of antigenMHC II moleculesPresentation of antigensDendritic cell abilityConditional knockout miceMHC-II complexesCD11c-CreRole of autophagyMHC-IIKnockout miceChimeric miceCytosolic antigensVivo requirementAntigen