2020
Conventional type 2 dendritic cells and natural killer cells mediate control of early metastatic seeding
Weizman O, Krykbaeva I, Bosenburg M, Iwasaki A. Conventional type 2 dendritic cells and natural killer cells mediate control of early metastatic seeding. The Journal Of Immunology 2020, 204: 88.17-88.17. DOI: 10.4049/jimmunol.204.supp.88.17.Peer-Reviewed Original ResearchConventional type 2 dendritic cellsType 2 dendritic cellsImmune cellsMetastatic burdenNK cellsDendritic cellsIntracardiac injectionHost anti-tumor immunityType I IFN-independent mannerAdaptive immune cellsAnti-tumor immunityLocal immune cellsNatural killer cellsSyngeneic mouse modelIFN-independent mannerEarly metastatic seedingMetastatic controlTranscription factor IRF3Killer cellsPrimary tumorMetastatic spreadInnate sensorsMouse modelMetastatic growthMetastatic seeding
2016
Early local immune defences in the respiratory tract
Iwasaki A, Foxman EF, Molony RD. Early local immune defences in the respiratory tract. Nature Reviews Immunology 2016, 17: 7-20. PMID: 27890913, PMCID: PMC5480291, DOI: 10.1038/nri.2016.117.Peer-Reviewed Original ResearchConceptsRespiratory tractImmune responseDendritic cellsType 2 immune responsesType 1 immune responsePlasmacytoid dendritic cellsEpithelial cellsTissue-resident lymphocytesLower respiratory tractType of infectionUpper respiratory tractAirway epithelial cellsLocal immune defensePattern recognition receptorsAntimicrobial host defenseLymphoid cell typesCell typesRespiratory infectionsEffector cellsSecrete cytokinesAllergen resultsInnate sensorsMast cellsAirway cellsPathological inflammation
2013
Innate immunity
Iwasaki A, Peiris M. Innate immunity. 2013, 267-282. DOI: 10.1002/9781118636817.ch17.Peer-Reviewed Original ResearchToll-like receptorsNOD-like receptorsImmune responseVirus infectionInfluenza virusHundreds of IFNProtective host responseInfluenza virus infectionAdaptive immune responsesInnate immune responseType I IFNInfluenza virus replicationInnate immune systemDendritic cellsNK cellsInfluenza infectionIL-1βInnate sensorsAdaptive immunityLike receptorsDetrimental pathologyI IFNAlveolar macrophagesHost responseImmune system
2012
Innate Immune Recognition of HIV-1
Iwasaki A. Innate Immune Recognition of HIV-1. Immunity 2012, 37: 389-398. PMID: 22999945, PMCID: PMC3578946, DOI: 10.1016/j.immuni.2012.08.011.Peer-Reviewed Original Research
2008
Innate sensors of influenza virus: clues to developing better intranasal vaccines
Ichinohe T, Iwasaki A, Hasegawa H. Innate sensors of influenza virus: clues to developing better intranasal vaccines. Expert Review Of Vaccines 2008, 7: 1435-1445. PMID: 18980544, PMCID: PMC2724183, DOI: 10.1586/14760584.7.9.1435.Peer-Reviewed Original ResearchConceptsInfluenza vaccineInnate sensorsVirus infectionImmune systemInfluenza virusIntranasal influenza vaccineVariant virus infectionNatural infectionEffective influenza vaccinesInfluenza virus infectionToll-like receptorsRetinoic acid-inducible geneNOD-like receptorsInnate immune systemPattern recognition receptorsAdaptive immune systemAcid-inducible geneParenteral immunizationIntranasal vaccineMucosal immunitySystemic immunityInactivated vaccinesRespiratory tractAdaptive immunityLike receptors