2011
Autophagy in the control and pathogenesis of viral infection
Yordy B, Iwasaki A. Autophagy in the control and pathogenesis of viral infection. Current Opinion In Virology 2011, 1: 196-203. PMID: 21927636, PMCID: PMC3171969, DOI: 10.1016/j.coviro.2011.05.016.Peer-Reviewed Original ResearchConceptsEukaryotic defense mechanismEukaryotic cell metabolismIntracellular pathogensVertebrate immune systemTime of starvationConstitutive autophagyCellular proteinsKey unanswered questionsCell metabolismAncient abilityAutophagyDefense mechanismsCell processesAntiviral immune responseRecent findingsPathogensCentral roleViral pathogensImmune systemOrganellesViral infectionMachineryUnanswered questionsImmune responseProteinCD4+ T cells support cytotoxic T lymphocyte priming by controlling lymph node input
Kumamoto Y, Mattei LM, Sellers S, Payne GW, Iwasaki A. CD4+ T cells support cytotoxic T lymphocyte priming by controlling lymph node input. Proceedings Of The National Academy Of Sciences Of The United States Of America 2011, 108: 8749-8754. PMID: 21555577, PMCID: PMC3102372, DOI: 10.1073/pnas.1100567108.Peer-Reviewed Original ResearchConceptsT cellsDendritic cellsCytotoxic T-lymphocyte primingT lymphocyte responsesAntigen-specific CTLsT lymphocyte primingSecondary lymphoid organsT cell helpCD40-dependent mannerNaïve B cellsCognate CTLsAcute infectionLymph nodesLymphocyte primingLymphocyte responsesLymphocyte recruitmentCTL expansionLymphoid organsImmune responseNaïve precursorsB cellsImmune systemReactive LNsIntracellular pathogensInfection
2009
CD8+ T lymphocyte mobilization to virus-infected tissue requires CD4+ T-cell help
Nakanishi Y, Lu B, Gerard C, Iwasaki A. CD8+ T lymphocyte mobilization to virus-infected tissue requires CD4+ T-cell help. Nature 2009, 462: 510-513. PMID: 19898495, PMCID: PMC2789415, DOI: 10.1038/nature08511.Peer-Reviewed Original ResearchConceptsT cell helpT cellsRecruitment of CD8Activity of CD4T lymphocyte responsesT helper cellsSecretion of interferonLymphocyte mobilizationCD4 helpCTL responsesCytotoxic CD8Lymphocyte responsesMucosal sitesChemokine secretionHelper cellsVirus-infected tissuesViral infectionCD4CD8Intracellular pathogensSecretionUnrecognized aspectsCellsInterferonInfection