2022
Unadjuvanted intranasal spike vaccine elicits protective mucosal immunity against sarbecoviruses
Mao T, Israelow B, Peña-Hernández MA, Suberi A, Zhou L, Luyten S, Reschke M, Dong H, Homer RJ, Saltzman WM, Iwasaki A. Unadjuvanted intranasal spike vaccine elicits protective mucosal immunity against sarbecoviruses. Science 2022, 378: eabo2523. PMID: 36302057, PMCID: PMC9798903, DOI: 10.1126/science.abo2523.Peer-Reviewed Original ResearchConceptsRespiratory mucosaSystemic immunityLethal SARS-CoV-2 infectionAcute respiratory syndrome coronavirus 2 pandemicSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemicSARS-CoV-2 infectionProtective mucosal immunityCross-reactive immunityT cell responsesCoronavirus 2 pandemicPrimary vaccinationParenteral vaccinesMucosal immunityVaccine strategiesRespiratory tractImmunoglobulin AMemory BImmune memoryPartial immunityCell responsesPoor immunityImmunitySpike proteinMucosaVaccine
2020
Chapter 43 Mucosal Vaccines for Genital Herpes
Oh J, Iwasaki A. Chapter 43 Mucosal Vaccines for Genital Herpes. 2020, 723-734. DOI: 10.1016/b978-0-12-811924-2.00043-2.Peer-Reviewed Original ResearchGenital herpesMucosal vaccinesHSV-2Immune responseSensory neuronsHerpes simplex virus type 2Simplex virus type 2Genital mucosal epitheliaLocal immune responseDorsal root gangliaHSV type 1Host immune responseVirus type 2Painful ulcersGenital mucosaMucosal immunityAsymptomatic sheddingHIV transmissionRoot gangliaRisk factorsSystemic immunityClinical trialsLifelong infectionMucosal epitheliumAntiviral drugs
2016
Exploiting Mucosal Immunity for Antiviral Vaccines
Iwasaki A. Exploiting Mucosal Immunity for Antiviral Vaccines. Annual Review Of Immunology 2016, 34: 575-608. PMID: 27168245, DOI: 10.1146/annurev-immunol-032414-112315.Peer-Reviewed Original ResearchConceptsMucosal immunityHuman immunodeficiency virusEffective immune protectionHost immune responseHerpes simplex virusImmunodeficiency virusMucosal vaccinesImmune protectionSuccessful vaccineImmune responseSimplex virusAntiviral vaccinesMucosal surfacesVaccine developmentVaccine designInfluenza virusFirst lineVaccineViral pathogensImmunityViral diseasesVirusDangerous pathogensPathogensDisease
2008
Innate sensors of influenza virus: clues to developing better intranasal vaccines
Ichinohe T, Iwasaki A, Hasegawa H. Innate sensors of influenza virus: clues to developing better intranasal vaccines. Expert Review Of Vaccines 2008, 7: 1435-1445. PMID: 18980544, PMCID: PMC2724183, DOI: 10.1586/14760584.7.9.1435.Peer-Reviewed Original ResearchConceptsInfluenza vaccineInnate sensorsVirus infectionImmune systemInfluenza virusIntranasal influenza vaccineVariant virus infectionNatural infectionEffective influenza vaccinesInfluenza virus infectionToll-like receptorsRetinoic acid-inducible geneNOD-like receptorsInnate immune systemPattern recognition receptorsAdaptive immune systemAcid-inducible geneParenteral immunizationIntranasal vaccineMucosal immunitySystemic immunityInactivated vaccinesRespiratory tractAdaptive immunityLike receptors
2005
Intestinal epithelial barrier and mucosal immunity
Sato A, Iwasaki A. Intestinal epithelial barrier and mucosal immunity. Cellular And Molecular Life Sciences 2005, 62: 1333. PMID: 15971108, DOI: 10.1007/s00018-005-5037-z.Peer-Reviewed Original ResearchConceptsDendritic cellsMucosal immunityPeyer's patchesMajor inductive siteMucosal dendritic cellsPP dendritic cellsResident dendritic cellsMucosal immune systemIntestinal epithelial barrierFood antigensInductive sitesGastrointestinal mucosaT cellsImmune inductionImmune responseRecent studiesEpithelial barrierImmune systemCommensal microbesSmall intestineA responsesInfectious pathogensImmunityAntigenInduction