2009
Autophagy and Innate Recognition Systems
Tal MC, Iwasaki A. Autophagy and Innate Recognition Systems. Current Topics In Microbiology And Immunology 2009, 335: 107-121. PMID: 19802562, DOI: 10.1007/978-3-642-00302-8_5.Peer-Reviewed Original ResearchConceptsAutophagic machineryInnate immune systemDouble-membrane structureViral replication complexProcess of autophagyImportant physiological processesInduction of autophagyInnate recognition systemsCellular homeostasisReplication complexPattern recognition receptorsAutophagy pathwayLysosomal degradationPhysiological processesCytosolic constituentsEfficient phagocytosisInnate pattern recognition receptorsRNA virusesAutophagyCytosolic sensorsKey moleculesExtracellular pathogensRecognition receptorsImmune systemViral sensors
2007
Autophagy-Dependent Viral Recognition by Plasmacytoid Dendritic Cells
Lee HK, Lund JM, Ramanathan B, Mizushima N, Iwasaki A. Autophagy-Dependent Viral Recognition by Plasmacytoid Dendritic Cells. Science 2007, 315: 1398-1401. PMID: 17272685, DOI: 10.1126/science.1136880.Peer-Reviewed Original ResearchConceptsPlasmacytoid dendritic cellsToll-like receptorsDendritic cellsInterferon-alpha secretionLive viral infectionPDC responsesViral infectionViral recognitionViral replicationPathogen signaturesTLR7VirusSuch virusesVirus detectionProcess of autophagyAutophagyRNA virusesCellsInfectionPresent evidenceSecretionReceptors