2016
CD301b+ dendritic cells suppress T follicular helper cells and antibody responses to protein antigens
Kumamoto Y, Hirai T, Wong PW, Kaplan DH, Iwasaki A. CD301b+ dendritic cells suppress T follicular helper cells and antibody responses to protein antigens. ELife 2016, 5: e17979. PMID: 27657168, PMCID: PMC5033605, DOI: 10.7554/elife.17979.Peer-Reviewed Original ResearchDendritic cellsAntibody responsePD-L1Protein antigensBlocking PD-1Follicular helper cellsPD-1 ligandsStrong antibody responseWild-type miceGerminal center B cellsTfh cellsPD-1Cell primingIgG responsesHelper cellsPD-L2Autoantibody generationSuccessful vaccineCD301bB cellsTransient depletionAntigenMiceAntibodiesNovel regulatory mechanismExploiting Mucosal Immunity for Antiviral Vaccines
Iwasaki A. Exploiting Mucosal Immunity for Antiviral Vaccines. Annual Review Of Immunology 2016, 34: 575-608. PMID: 27168245, DOI: 10.1146/annurev-immunol-032414-112315.Peer-Reviewed Original ResearchConceptsMucosal immunityHuman immunodeficiency virusEffective immune protectionHost immune responseHerpes simplex virusImmunodeficiency virusMucosal vaccinesImmune protectionSuccessful vaccineImmune responseSimplex virusAntiviral vaccinesMucosal surfacesVaccine developmentVaccine designInfluenza virusFirst lineVaccineViral pathogensImmunityViral diseasesVirusDangerous pathogensPathogensDisease
2010
Antiviral immune responses in the genital tract: clues for vaccines
Iwasaki A. Antiviral immune responses in the genital tract: clues for vaccines. Nature Reviews Immunology 2010, 10: 699-711. PMID: 20829886, PMCID: PMC3678359, DOI: 10.1038/nri2836.Peer-Reviewed Original ResearchConceptsGenital mucosaT cellsGenital tractHerpes simplex virus type 2Simplex virus type 2Innate immune cellsT cell populationsAntiviral immune responseFemale genital tractPattern recognition receptorsVirus type 2Immune correlatesMemory CD4Memory CD8Viral clearanceHuman papillomavirusImmune cellsMemory lymphocytesSuccessful vaccineHIV-1Immune responseSevere diseaseVaginal epitheliumAdaptive immunityTarget cell type