2019
Antigen presentation by CD301b+ dermal dendritic cells dictates CD4+ T cell fate
Tatsumi N, Iwasaki A, Kumamoto Y. Antigen presentation by CD301b+ dermal dendritic cells dictates CD4+ T cell fate. The Journal Of Immunology 2019, 202: 56.9-56.9. DOI: 10.4049/jimmunol.202.supp.56.9.Peer-Reviewed Original ResearchCD4 T cellsOT-II cellsAntigen-specific CD4 T cellsDermal dendritic cellsDendritic cellsMHC class IIT cellsTh2 differentiationAntigen presentationCognate interactionPolyclonal CD4T cellsT cells 7 daysEffector CD4 T cellsT helper type 2 cellsMajor DC subsetsIL-4 productionEpidermal Langerhans cellsCells 7 daysType 2 cellsDC subsetsT cell fateLymph nodesOverall cell cycle progressionLangerhans cellsTh2 cells
2013
CD301b+ Dermal Dendritic Cells Drive T Helper 2 Cell-Mediated Immunity
Kumamoto Y, Linehan M, Weinstein JS, Laidlaw BJ, Craft JE, Iwasaki A. CD301b+ Dermal Dendritic Cells Drive T Helper 2 Cell-Mediated Immunity. Immunity 2013, 39: 733-743. PMID: 24076051, PMCID: PMC3819035, DOI: 10.1016/j.immuni.2013.08.029.Peer-Reviewed Original ResearchConceptsDermal dendritic cellsDendritic cellsDermal DCsTh2 cellsT cellsT helper 2 cellsT helper responsesInterleukin-4 productionExpression of CD69Th2 cell developmentDC depletionLymph nodesTh2 immunityHelper responsesSubcutaneous immunizationNippostrongylus brasiliensisKey mediatorTransient depletionCell developmentImmunityOvalbuminDepletion approachCellsParticular subsetCD301b