Dual recognition of herpes simplex viruses by TLR2 and TLR9 in dendritic cells
Sato A, Linehan MM, Iwasaki A. Dual recognition of herpes simplex viruses by TLR2 and TLR9 in dendritic cells. Proceedings Of The National Academy Of Sciences Of The United States Of America 2006, 103: 17343-17348. PMID: 17085599, PMCID: PMC1859932, DOI: 10.1073/pnas.0605102103.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell LineCytokinesDendritic CellsGenetic VariationHumansLipopolysaccharide ReceptorsMiceMice, KnockoutSimplexvirusToll-Like Receptor 2Toll-Like Receptor 9ConceptsToll-like receptorsHerpes simplex virusMultiple Toll-like receptorsDendritic cellsSimplex virusBone marrow-derived dendritic cellsMarrow-derived dendritic cellsMultiple pathogen-associated molecular patternsPrimary clinical isolatesIL-12 secretionConventional dendritic cellsSame dendritic cellInnate immune systemPathogen-associated molecular patternsViral infection resultsProinflammatory cytokinesSurface TLR2IL-6Infection resultsTLR2TLR9Viral recognitionImmune systemClinical isolatesAdditional agonists