2011
Microbiota regulates immune defense against respiratory tract influenza A virus infection
Ichinohe T, Pang IK, Kumamoto Y, Peaper DR, Ho JH, Murray TS, Iwasaki A. Microbiota regulates immune defense against respiratory tract influenza A virus infection. Proceedings Of The National Academy Of Sciences Of The United States Of America 2011, 108: 5354-5359. PMID: 21402903, PMCID: PMC3069176, DOI: 10.1073/pnas.1019378108.Peer-Reviewed Original ResearchConceptsInfluenza virus infectionVirus infectionDendritic cellsImmune responseCommensal bacteriaRespiratory influenza virus infectionToll-like receptor ligandsVirus-specific CD4CD8 T cellsT cell primingCommensal microbiota compositionProductive immune responseExpression of mRNADistal injectionLymph nodesImmune impairmentIntact microbiotaIL-1βAntibody responseImmune homeostasisRespiratory mucosaAntibiotic treatmentT cellsInflammasome activationCommensal microbiota
2007
Mucosal Dendritic Cells
Iwasaki A. Mucosal Dendritic Cells. Annual Review Of Immunology 2007, 25: 381-418. PMID: 17378762, DOI: 10.1146/annurev.immunol.25.022106.141634.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigen PresentationDendritic CellsHomeostasisHumansImmunity, InnateImmunity, MucosalMucous MembraneConceptsMucosal dendritic cellsDendritic cellsMucosal surfacesSpecialized dendritic cellsRobust protective immunityAdaptive immune systemMucus-secreting cellsProtective immunityEnvironmental antigensMucosal barrierCommensal floraImmune systemEpithelial cellsRecognition of microorganismsAntigenAppropriate local responsesCellsVital functionsResponsePathogensAbsence of pathogensExcretionImmunity