2022
Advances in antibody-drug conjugates for gynecologic malignancies
Tymon-Rosario J, Gorman M, Richardson D, Washington C, Santin A. Advances in antibody-drug conjugates for gynecologic malignancies. Current Opinion In Obstetrics & Gynecology 2022, 35: 6-14. PMID: 36484278, DOI: 10.1097/gco.0000000000000838.Peer-Reviewed Original ResearchConceptsAntibody-drug conjugatesOvarian cancer patientsGynecologic malignanciesCancer patientsPlatinum-resistant ovarian cancer patientsUse of ADCsOngoing phase 3 trialsRecurrent ovarian cancer patientsNovel antibody-drug conjugateReceptor-targeting antibodiesPhase 3 trialProgression-free survivalFirst U.S. FoodOngoing clinical trialsHER2/neuPersonalized cancer careTisotumab vedotinPrimary endpointCervical cancerGynecologic cancerCancer careClinical trialsMultiple tumorsCurrent evidenceDrug Administration
2021
Novel mesothelin antibody-drug conjugates: current evidence and future role in the treatment of ovarian cancer
Mauricio D, Harold J, Tymon-Rosario JR, Zeybek B, Santin AD. Novel mesothelin antibody-drug conjugates: current evidence and future role in the treatment of ovarian cancer. Expert Opinion On Biological Therapy 2021, 21: 1087-1096. PMID: 33356644, DOI: 10.1080/14712598.2021.1869210.Peer-Reviewed Original ResearchConceptsAntibody-drug conjugatesOvarian cancerProgressive diseaseFavorable adverse effect profilePromising novel therapeutic agentAdverse effect profilePhase II trialDeadliest gynecologic malignancyPhase III dataNovel therapeutic agentsII trialGynecologic malignanciesEffect profileClinical resultsEffective therapyAvailable agentsCurrent evidenceNovel treatmentsChemotherapeutic agentsCancerTherapeutic agentsAdverse effectsMesothelinVivo dataDisease
2016
The Role of the Immune System in Ovarian Cancer and Implications on Therapy
Menderes G, Schwab CL, Black J, Santin AD. The Role of the Immune System in Ovarian Cancer and Implications on Therapy. Expert Review Of Clinical Immunology 2016, 12: 681-695. PMID: 26821930, DOI: 10.1586/1744666x.2016.1147957.Peer-Reviewed Original ResearchConceptsOvarian cancerImmune systemGoal of immunotherapyConventional cytotoxic chemotherapyCause of deathAdvanced surgical techniquesDifferent immunotherapiesTremendous toxicityCytotoxic chemotherapyGynecologic malignanciesDisease recurrenceMicroscopic diseaseTreatment optionsImmune modulationSurgical techniqueCurrent evidenceDisease pathogenesisCurrent ongoing studiesCancerImmunotherapyRecurrenceOngoing studiesChemotherapyMalignancyPathogenesis
2014
Past, present and future targets for immunotherapy in ovarian cancer
Schwab CL, English DP, Roque DM, Pasternak M, Santin AD. Past, present and future targets for immunotherapy in ovarian cancer. Immunotherapy 2014, 6: 1279-1293. PMID: 25524384, PMCID: PMC4312614, DOI: 10.2217/imt.14.90.Peer-Reviewed Original ResearchConceptsOvarian cancerImmune systemGoal of immunotherapyOvarian cancer immunotherapyConventional cytotoxic chemotherapyCause of deathAdvanced surgical techniquesDifferent immunotherapiesTremendous toxicityCytotoxic chemotherapyGynecologic malignanciesDisease recurrenceMicroscopic diseaseCancer immunotherapyImmune modulationSurgical techniqueCurrent evidenceImmunotherapyCurrent ongoing studiesCancerRecurrenceOngoing studiesFuture targetsChemotherapyMalignancyFIGO 2008 staging for endometrial cancer
English D, Santin A. FIGO 2008 staging for endometrial cancer. 2014, 82-96. DOI: 10.2217/fmeb2013.13.115.Peer-Reviewed Original ResearchFIGO staging systemEndometrial cancer patientsStaging systemEndometrial cancerCancer patientsCervical glandular involvementFIGO stage 1AObstetrics (FIGO) staging systemPositive peritoneal cytologySurgical staging systemClinical staging systemPeritoneal cytologySurgical stagingClinicopathologic studyOverall survivalGlandular involvementPathologic findingsEndometrial carcinomaDisease stageSignificant changesStage 1ACurrent evidenceInvolved nodesAssignment of stageCancer