2013
Updates in therapy for uterine serous carcinoma
Roque DM, Santin AD. Updates in therapy for uterine serous carcinoma. Current Opinion In Obstetrics & Gynecology 2013, 25: 29-37. PMID: 23138439, DOI: 10.1097/gco.0b013e32835af98d.Peer-Reviewed Original ResearchConceptsUterine serous carcinomaSerous carcinomaTreatment of USCPaclitaxel-resistant diseasePI3/Akt/mTOR pathwayClass III β-tubulinEarly-stage diseaseNew target antigensAKT/mTOR pathwayVascular endothelial growth factorDistinct molecular pathogenesisHER2/neuIII β-tubulinCurrent clinical approachesEndothelial growth factorNovel microtubule-stabilizing agentEndometrial cancerAggressive variantOptimal therapyProspective studyPathway aberrationsClinical investigationSmall molecule inhibitorsTarget antigenClinical approach
2005
3 Role of Immunohistochemical Expression of HER2/neu in High-Grade Ovarian Serous Papillary Cancer
Santin A. 3 Role of Immunohistochemical Expression of HER2/neu in High-Grade Ovarian Serous Papillary Cancer. Handbook Of Immunohistochemistry And In Situ Hybridization Of Human Carcinomas 2005, 4: 333-338. DOI: 10.1016/s1874-5784(05)80089-3.Peer-Reviewed Original ResearchHER2/neuEpidermal growth factor receptorHER2/neu protein overexpressionLymphocyte-activated killer cellsTumor necrosis factor alphaHER2/neu overexpressionPapillary cancer tissuesVascular endothelial growth factorNecrosis factor alphaShorter patient survivalHER2/neu functionNeu protein overexpressionEndothelial growth factorHER2/neu gene productGrowth factor receptorHormonal therapyKiller cellsGynecologic tumorsPatient survivalPapillary cancerNeu overexpressionOvarian carcinomaHistologic evaluationImmunohistochemical expressionDifferential diagnosis
1999
Secretion of Vascular Endothelial Growth Factor in Adenocarcinoma and Squamous Cell Carcinoma of the Uterine Cervix
SANTIN A, HERMONAT P, RAVAGGI A, PECORELLI S, CANNON M, PARHAM G. Secretion of Vascular Endothelial Growth Factor in Adenocarcinoma and Squamous Cell Carcinoma of the Uterine Cervix. Obstetrics And Gynecology 1999, 94: 78-82. DOI: 10.1097/00006250-199907000-00015.Peer-Reviewed Original ResearchConceptsVascular endothelial growth factorSquamous cell carcinomaEndothelial growth factorVascular endothelial growth factor (VEGF) secretionSquamous cell linesUterine cervixCell carcinomaGrowth factor secretionGrowth factorFactor secretionCell linesSensitive enzyme-linked immunosorbentSignificant differencesEnzyme-linked immunosorbentCervical carcinoma cell linesImmunosuppressive cytokinesHistologic typeCervical cancerCarcinoma cell linesCervical tumorsBiologic behaviorHematogenous metastasisAdenocarcinomaCervixRadiation treatmentSecretion of vascular endothelial growth factor in adenocarcinoma and squamous cell carcinoma of the uterine cervix.
Santin A, Hermonat P, Ravaggi A, Pecorelli S, Cannon M, Parham G. Secretion of vascular endothelial growth factor in adenocarcinoma and squamous cell carcinoma of the uterine cervix. Obstetrics And Gynecology 1999, 94: 78-82. PMID: 10389722, DOI: 10.1016/s0029-7844(99)00282-3.Peer-Reviewed Original ResearchConceptsVascular endothelial growth factorSquamous cell carcinomaEndothelial growth factorVascular endothelial growth factor (VEGF) secretionSquamous cell linesUterine cervixCell carcinomaGrowth factor secretionGrowth factorFactor secretionCell linesSensitive enzyme-linked immunosorbentSignificant differencesEnzyme-linked immunosorbentCervical carcinoma cell linesImmunosuppressive cytokinesHistologic typeCervical cancerCarcinoma cell linesCervical tumorsBiologic behaviorHematogenous metastasisAdenocarcinomaCervixRadiation treatmentSecretion of vascular endothelial growth factor in ovarian cancer.
Santin AD, Hermonat PL, Ravaggi A, Cannon MJ, Pecorelli S, Parham GP. Secretion of vascular endothelial growth factor in ovarian cancer. European Journal Of Gynaecological Oncology 1999, 20: 177-81. PMID: 10410879.Peer-Reviewed Original ResearchConceptsVascular endothelial growth factorOvarian cancer patientsCancer patientsOvarian carcinoma cell linesEnzyme-linked immunosorbent assayEndothelial growth factorOvarian cancerCarcinoma cell linesAscitic fluidFluid accumulationLow vascular endothelial growth factorVEGF secretionGrowth factorTumor-Induced ImmunosuppressionVascular endothelial cell functionDefective immune functionHigh-grade malignancyLow-grade tumorsHuman ovarian carcinoma cell linesAnti-angiogenic treatmentNovel therapeutic approachesPeritoneal fluid accumulationAction of VEGFCell linesAscitic fluid accumulation