2008
Trefoil factor 3: a novel serum marker identified by gene expression profiling in high-grade endometrial carcinomas
Bignotti E, Ravaggi A, Tassi RA, Calza S, Rossi E, Falchetti M, Romani C, Bandiera E, Odicino FE, Pecorelli S, Santin AD. Trefoil factor 3: a novel serum marker identified by gene expression profiling in high-grade endometrial carcinomas. British Journal Of Cancer 2008, 99: 768-773. PMID: 18682706, PMCID: PMC2528153, DOI: 10.1038/sj.bjc.6604546.Peer-Reviewed Original ResearchConceptsTrefoil factor 3Novel serum markerG3 EECSerum markersEndometrial carcinomaHigh-grade endometrial carcinomasEndometrial hyperplasia patientsEndometrioid endometrial carcinomaEndometrial hyperplasiaSerum levelsHyperplasia patientsHealthy patientsSerum concentrationsQuantitative real-time PCRHealthy controlsReal-time PCREndometrium biopsyTFF3 expressionPatientsTFF3 proteinEarly detectionGene expression profilingProtein levelsQRT-PCRExpression levelsMammaglobin B expression in human endometrial cancer
TASSI RA, BIGNOTTI E, FALCHETTI M, CALZA S, RAVAGGI A, ROSSI E, MARTINELLI F, BANDIERA E, PECORELLI S, SANTIN AD. Mammaglobin B expression in human endometrial cancer. International Journal Of Gynecological Cancer 2008, 18: 1090-1096. PMID: 18021217, DOI: 10.1111/j.1525-1438.2007.01137.x.Peer-Reviewed Original ResearchConceptsReal-time polymerase chain reactionPolymerase chain reactionG3 casesNormal endometrial cellsHuman endometrial cancerFresh frozen biopsiesSignificant higher levelsParaffin-embedded tissuesEndometrial cancerG1 casesMammaglobin BNormal endometriumEndometrial tumorsEndometrial cellsOvarian cancerFrozen biopsyNovel molecular markersB expressionNEC controlsGene expression profilingImmunohistochemistryProtein expressionProtein levelsG2 casesChain reaction
2007
Gene expression profile of ovarian serous papillary carcinomas: identification of metastasis-associated genes
Bignotti E, Tassi RA, Calza S, Ravaggi A, Bandiera E, Rossi E, Donzelli C, Pasinetti B, Pecorelli S, Santin AD. Gene expression profile of ovarian serous papillary carcinomas: identification of metastasis-associated genes. American Journal Of Obstetrics And Gynecology 2007, 196: 245.e1-245.e11. PMID: 17346539, DOI: 10.1016/j.ajog.2006.10.874.Peer-Reviewed Original ResearchConceptsMetastasis-associated genesGene expressionOverexpression of CXCL12Gene expression profilesGene expression profilingMetastatic ovarian cancerNumber of invasionsHepsin geneHuman genesExpression profilingExpression profilesOligonucleotide microarraysQuantitative real-time polymerase chain reactionOvarian cancerGenesProbe setsPrimary ovarian serous carcinomaOvarian serous papillary carcinomaSerous papillary ovarian carcinomasProtein levelsSerous papillary carcinomaReal-time polymerase chain reactionOvarian serous carcinomaOspCPredictive genes
2006
Differential gene expression profiles between tumor biopsies and short-term primary cultures of ovarian serous carcinomas: Identification of novel molecular biomarkers for early diagnosis and therapy
Bignotti E, Tassi RA, Calza S, Ravaggi A, Romani C, Rossi E, Falchetti M, Odicino FE, Pecorelli S, Santin AD. Differential gene expression profiles between tumor biopsies and short-term primary cultures of ovarian serous carcinomas: Identification of novel molecular biomarkers for early diagnosis and therapy. Gynecologic Oncology 2006, 103: 405-416. PMID: 16725184, DOI: 10.1016/j.ygyno.2006.03.056.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overBiomarkers, TumorBiopsyClaudin-3Claudin-4Cystadenocarcinoma, SerousEpithelial CellsFemaleGene Expression ProfilingHumansImmunohistochemistryKallikreinsMammaglobin AMembrane ProteinsMiddle AgedNeoplasm ProteinsOvarian NeoplasmsReverse Transcriptase Polymerase Chain ReactionTumor Cells, CulturedUteroglobinConceptsGene expression profilesGene expression profilingExpression profilingExpression profilesGenetic fingerprintsDifferential gene expression profilesNovel molecular biomarkersGene expression productsOvarian serous papillary carcinomaGene expression dataHuman genesGene expressionMolecular biomarkersOligonucleotide microarraysExpression productsPrimary tumor cell culturesExpression dataQuantitative RT-PCREnterotoxin receptorGenesMicroarray dataKallikrein 6Ovarian serous carcinomaProtein levelsMammaglobin 2
2004
Discrimination between uterine serous papillary carcinomas and ovarian serous papillary tumours by gene expression profiling
Santin AD, Zhan F, Bellone S, Palmieri M, Cane S, Gokden M, Roman JJ, O'Brien TJ, Tian E, Cannon MJ, Shaughnessy J, Pecorelli S. Discrimination between uterine serous papillary carcinomas and ovarian serous papillary tumours by gene expression profiling. British Journal Of Cancer 2004, 90: 1814-1824. PMID: 15208622, PMCID: PMC2409747, DOI: 10.1038/sj.bjc.6601791.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedCarcinoma, PapillaryCells, CulturedCystadenocarcinoma, SerousDiagnosis, DifferentialFemaleFlow CytometryGene Expression ProfilingGene Expression Regulation, NeoplasticHumansImmunohistochemistryMiddle AgedOligonucleotide Array Sequence AnalysisOvarian NeoplasmsReceptor, ErbB-2Reverse Transcriptase Polymerase Chain ReactionUterine NeoplasmsConceptsUterine serous papillary carcinomaGene expressionOverexpressed genesSerous papillary carcinomaGene expression fingerprintGene expression profilingHuman genesC-erbB2 geneExpression fingerprintsMolecular basisExpression profilingPapillary carcinomaOligonucleotide microarraysExpression productsQuantitative RT-PCRGenesClinical tissue samplesProbe setsTwo-fold differenceMore effective treatment modalitiesEffective treatment modalitySerous papillary tumorsPlasminogen activator inhibitorDifferent biological behaviorDevelopment of novel