2016
Tumor-associated macrophages drive spheroid formation during early transcoelomic metastasis of ovarian cancer
Yin M, Li X, Tan S, Zhou HJ, Ji W, Bellone S, Xu X, Zhang H, Santin AD, Lou G, Min W. Tumor-associated macrophages drive spheroid formation during early transcoelomic metastasis of ovarian cancer. Journal Of Clinical Investigation 2016, 126: 4157-4173. PMID: 27721235, PMCID: PMC5096908, DOI: 10.1172/jci87252.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsErbB ReceptorsFemaleHeterograftsHumansIntercellular Adhesion Molecule-1Macrophage-1 AntigenMacrophagesMiceMice, NudeNeoplasm MetastasisNeoplasm ProteinsNeoplasm TransplantationOvarian NeoplasmsSpheroids, CellularVascular Endothelial Growth Factor AVascular Endothelial Growth Factor Receptor-1ConceptsTumor-associated macrophagesOvarian cancerTranscoelomic metastasisTumor cellsICAM-1Mouse modelEpithelial ovarian cancerOvarian cancer growthOvarian cancer metastasisSpheroid formationOvarian cancer progressionVEGF/VEGFRTumor cell proliferationPharmacological blockadeMetastatic cancerColon cancerCancer growthMetastasisAntibody neutralizationTumor growthCancerClinical pathologyCancer metastasisCancer progressionΑMβ2 integrin
1999
Expression of Surface Antigens During the Differentiation of Human Dendritic Cells vs Macrophages from Blood Monocytes in vitro
Santin A, Hermonat P, Ravaggi M, Chiriva-Internat M, Cannon M, Hiserodt J, Pecorell S, Parham G. Expression of Surface Antigens During the Differentiation of Human Dendritic Cells vs Macrophages from Blood Monocytes in vitro. Immunobiology 1999, 200: 187-204. PMID: 10416127, DOI: 10.1016/s0171-2985(99)80069-2.Peer-Reviewed Original ResearchMeSH KeywordsAntigens, CDAntigens, CD1Antigens, SurfaceB7-1 AntigenB7-2 AntigenCD40 AntigensCD58 AntigensCell AdhesionCell DifferentiationCell DivisionCells, CulturedDendritic CellsGranulocyte-Macrophage Colony-Stimulating FactorHistocompatibility Antigens Class IHistocompatibility Antigens Class IIHumansImmunoglobulinsImmunophenotypingIntercellular Adhesion Molecule-1Interleukin-4Leukocytes, MononuclearLipopolysaccharide ReceptorsMacrophagesMembrane GlycoproteinsMonocytesT-LymphocytesConceptsDendritic cellsICAM-1 expressionMHC class IIBlood monocytesCostimulation moleculesDay 3Day 10MHC antigensCD14 expressionICAM-1Day 5Majority of DCNaive T cell primingClass IIDifferentiation of DCsProfessional antigen presenting cellsT cell primingHuman dendritic cellsMHC class II moleculesAntigen presenting cellsGM-CSF/ILClass II moleculesMHC class IImportant surface moleculesEarly time points
1998
Effects of retinoic acid on the expression of a tumor rejection antigen (heat shock protein gp96) in human cervical cancer.
Santin AD, Hermonat PL, Ravaggi A, Chiriva-Internati M, Pecorelli S, Parham GP. Effects of retinoic acid on the expression of a tumor rejection antigen (heat shock protein gp96) in human cervical cancer. European Journal Of Gynaecological Oncology 1998, 19: 229-33. PMID: 9641219.Peer-Reviewed Original ResearchConceptsHeat shock protein gp96Shock protein gp96Tumor rejection antigensHuman cervical cancerCervical cancerRetinoic acidRejection antigensTumor cellsMajor histocompatibility complex class IPresentation of tumorHistocompatibility complex class IBiologic response modifiersCervical cancer cell linesCo-stimulation moleculesComplex class ICell linesCervical carcinoma cell linesHuman cervical carcinoma cell lineCancer cell linesCarcinoma cell linesHumoral immunityTherapeutic dosesViral antigensResponse modifiersICAM-1The effects of irradiation on the expression of a tumour rejection antigen (heat shock protein gp96) in human cervical cancer
Santin AD, Hermonat PL, Ravaggi A, Chiriva-Internati M, Hiserodt JC, Batchu RB, Pecorelli S, Parham GP. The effects of irradiation on the expression of a tumour rejection antigen (heat shock protein gp96) in human cervical cancer. International Journal Of Radiation Biology 1998, 73: 699-704. PMID: 9690688, DOI: 10.1080/095530098141951.Peer-Reviewed Original ResearchConceptsTumor rejection antigensHeat shock protein gp96Shock protein gp96Human cervical cancerCervical carcinoma cell linesRejection antigensHigh dosesHuman cervical carcinoma cell lineCervical cancerCarcinoma cell linesTumor cellsMajor histocompatibility complex class ILocal radiation therapyHistocompatibility complex class IBiologic response modifiersCo-stimulation moleculesComplex class ICell linesCervical cancer cellsDose-dependent mannerViral antigensResponse modifiersICAM-1Radiation therapyGp96 mRNA
1997
Effects of irradiation on the expression of major histocompatibility complex class I antigen and adhesion costimulation molecules ICAM-1 in human cervical cancer
Santin A, Hermonat P, Hiserodt J, Chiriva-Internati M, Woodliff J, Theus J, Barclay D, Pecorelli S, Parham G. Effects of irradiation on the expression of major histocompatibility complex class I antigen and adhesion costimulation molecules ICAM-1 in human cervical cancer. International Journal Of Radiation Oncology • Biology • Physics 1997, 39: 737-742. PMID: 9336157, DOI: 10.1016/s0360-3016(97)00372-6.Peer-Reviewed Original ResearchConceptsMHC class ISurface antigenClass IAntigen expressionICAM-1High dosesClass II surface antigensCell linesSiHa cervical cancer cellsMajor histocompatibility complex class IHistocompatibility complex class IICAM-1 antigenMolecules ICAM-1Cell replicationSurface antigen expressionHuman cervical cancerComplex class ICervical cancer cellsCervical carcinoma cell linesCervical cell linesHuman cervical carcinoma cell lineDifferent time pointsCervical cancerCarcinoma cell linesHigh radiation dosesExpression and cytokine mediated modulation of adhesion/costimulation molecules ICAM‐1(CD54) and LFA‐3(CD58) in human ovarian cancer
SANTIN A, HERMONAT P, HISERODT J, CHIRIVA‐INTERNATI M, RAVAGGI A, WOODLIFF J, BARCLAY D, PECORELLI S, PARHAM G. Expression and cytokine mediated modulation of adhesion/costimulation molecules ICAM‐1(CD54) and LFA‐3(CD58) in human ovarian cancer. International Journal Of Gynecological Cancer 1997, 7: 273-278. DOI: 10.1046/j.1525-1438.1997.00453.x.Peer-Reviewed Original ResearchTumor cellsICAM-1Fresh tumorsFresh ovarian tumor cellsClonal T-cell proliferationICAM-1/LFAICAM-1 antigenT cell proliferationMolecules ICAM-1Human ovarian cancerHuman ovarian tumorsLFA-3 antigensOvarian tumor cellsSurface antigen expressionAntigen-independent conjugate formationLFA-3 moleculesT cell recognitionNumber of cytokinesCostimulation pathwayTumor vaccinesCostimulatory moleculesOvarian tumorsHelper cytokinesIL-2Cytokines TNF
1996
Effects of Irradiation on the Expression of Surface Antigens in Human Ovarian Cancer
Santin A, Hiserodt J, Fruehauf J, DiSaia P, Pecorelli S, Granger G. Effects of Irradiation on the Expression of Surface Antigens in Human Ovarian Cancer. Gynecologic Oncology 1996, 60: 468-474. PMID: 8774659, DOI: 10.1006/gyno.1996.0075.Peer-Reviewed Original ResearchConceptsMHC class ISurface antigenHER2-neuHigh dosesClass IITumor cellsCell linesClass IICAM-1 antigenHuman ovarian cancerHuman ovarian carcinoma cell linesOvarian carcinoma cell linesCA 125Carcinoma cell linesOvarian cancerICAM-1Radiation therapyIrradiation-induced upregulationImmune recognitionTumor tissueAntigenDosesCellsExposureExpression
1995
Development and Characterization of an IL-4-Secreting Human Ovarian Carcinoma Cell Line
Santin A, Ioli G, Hiserodt J, Rose G, Graf M, Tocco L, Lander J, Eck L, Burger R, DiSaia P, Pecorelli S, Granger G. Development and Characterization of an IL-4-Secreting Human Ovarian Carcinoma Cell Line. Gynecologic Oncology 1995, 58: 230-239. PMID: 7622110, DOI: 10.1006/gyno.1995.1216.Peer-Reviewed Original ResearchMeSH KeywordsAntigens, NeoplasmAntigens, SurfaceCell DivisionCell SurvivalClone CellsCystadenocarcinoma, PapillaryDNA, NeoplasmDNA, ViralFemaleGenetic VectorsHistocompatibility Antigens Class IHumansIntercellular Adhesion Molecule-1Interleukin-4KineticsOvarian NeoplasmsPlasmidsRetroviridaeTransduction, GeneticTumor Cells, CulturedVaccinesConceptsHuman ovarian carcinoma cell linesOvarian carcinoma cell linesCarcinoma cell linesInterleukin-4UCI-107Detectable MHC class IICell linesAdvanced ovarian cancerIL-4 secretionMHC class IICytokine interleukin-4IL-4 receptorMHC class ILXSN retroviral vectorOvarian carcinoma cellsIL-4 geneMonths of studyCA 125Ovarian cancerICAM-1Parental cell lineDay 8Vector control cellsClass IIUCI 101