1998
Retinoic acid up-regulates the expression of major histocompatibility complex molecules and adhesion/costimulation molecules (specifically, intercellular adhesion molecule ICAM-1) in human cervical cancer
Santin A, Hermonat P, Ravaggi A, Chiriva-Internati M, Pecorelli S, Parham G. Retinoic acid up-regulates the expression of major histocompatibility complex molecules and adhesion/costimulation molecules (specifically, intercellular adhesion molecule ICAM-1) in human cervical cancer. American Journal Of Obstetrics And Gynecology 1998, 179: 1020-1025. PMID: 9790391, DOI: 10.1016/s0002-9378(98)70209-1.Peer-Reviewed Original ResearchMeSH KeywordsBlotting, NorthernFemaleFlow CytometryFluorescent Antibody Technique, IndirectGene Expression Regulation, NeoplasticHistocompatibility Antigens Class IHistocompatibility Antigens Class IIHumansIntercellular Adhesion Molecule-1RNA, MessengerTretinoinTumor Cells, CulturedUterine Cervical NeoplasmsConceptsMajor histocompatibility complex class IHistocompatibility complex class IComplex class IICAM-1 antigenCervical cancerCervical carcinoma cell linesSurface antigenClass IHuman cervical carcinoma cell lineRetinoic acidCarcinoma cell linesTherapeutic dosesHuman leukocyte antigen (HLA) class IClass II surface antigensCell linesAdhesion molecules ICAM-1Fluorescence-activated cell sorter analysisIntercellular adhesion molecule ICAM-1Additional clinical researchHuman leukocyte antigenMajor histocompatibility complex moleculesAntigen class IMolecules ICAM-1Use of retinoidsUntreated tumor cellsEffects of Retinoic Acid Combined with Irradiation on the Expression of Major Histocompatibility Complex Molecules and Adhesion/Costimulation Molecules ICAM-1 in Human Cervical Cancer
Santin A, Hermonat P, Ravaggi A, Chiriva-Internati M, Hiserodt J, Pecorelli S, Parham G. Effects of Retinoic Acid Combined with Irradiation on the Expression of Major Histocompatibility Complex Molecules and Adhesion/Costimulation Molecules ICAM-1 in Human Cervical Cancer. Gynecologic Oncology 1998, 70: 195-201. PMID: 9740690, DOI: 10.1006/gyno.1998.5060.Peer-Reviewed Original ResearchConceptsIntercellular adhesion molecule-1Class II surface antigensICAM-1 antigenSurface antigenMHC class ICervical cancer cellsClass IRetinoic acidCervical cancerHigh dosesUpregulated HLA class ITumor cellsSiHa cervical cancer cellsMajor histocompatibility complex class ICancer cellsHistocompatibility complex class IMajor histocompatibility complex moleculesMolecules ICAM-1Adhesion molecule-1HLA class IICAM-1 moleculesUntreated tumor cellsHuman cervical cancerCervical cancer therapyComplex class IEffects of retinoic acid combined with interferon‐gamma on the expression of major‐histocompatibility‐complex molecules and intercellular adhesion molecule‐1 in human cervical cancer
Santin A, Hermonat P, Ravaggi A, Chiriva‐Internati M, Hiserodt J, Tian E, Carter C, Pecorelli S, Parham G. Effects of retinoic acid combined with interferon‐gamma on the expression of major‐histocompatibility‐complex molecules and intercellular adhesion molecule‐1 in human cervical cancer. International Journal Of Cancer 1998, 75: 254-258. PMID: 9462716, DOI: 10.1002/(sici)1097-0215(19980119)75:2<254::aid-ijc14>3.0.co;2-d.Peer-Reviewed Original ResearchConceptsMHC class IIIFN-gammaHuman cervical cancerCervical cancerHLA classTrans retinoic acidMHC classI mRNA expressionRetinoic acidSurface antigenTumor cellsIntercellular adhesion molecule-1Biologic response modifiersICAM-1 antigenAdhesion molecule-1ICAM-1 moleculesUntreated tumor cellsCell linesCervical cancer cellsICAM-1 surfaceCervical carcinoma cell linesAnti-proliferative effectsHuman cervical cancer cellsHuman cervical carcinoma cell lineResponse modifiers
1997
Effects of irradiation on the expression of major histocompatibility complex class I antigen and adhesion costimulation molecules ICAM-1 in human cervical cancer
Santin A, Hermonat P, Hiserodt J, Chiriva-Internati M, Woodliff J, Theus J, Barclay D, Pecorelli S, Parham G. Effects of irradiation on the expression of major histocompatibility complex class I antigen and adhesion costimulation molecules ICAM-1 in human cervical cancer. International Journal Of Radiation Oncology • Biology • Physics 1997, 39: 737-742. PMID: 9336157, DOI: 10.1016/s0360-3016(97)00372-6.Peer-Reviewed Original ResearchConceptsMHC class ISurface antigenClass IAntigen expressionICAM-1High dosesClass II surface antigensCell linesSiHa cervical cancer cellsMajor histocompatibility complex class IHistocompatibility complex class IICAM-1 antigenMolecules ICAM-1Cell replicationSurface antigen expressionHuman cervical cancerComplex class ICervical cancer cellsCervical carcinoma cell linesCervical cell linesHuman cervical carcinoma cell lineDifferent time pointsCervical cancerCarcinoma cell linesHigh radiation dosesExpression and cytokine mediated modulation of adhesion/costimulation molecules ICAM‐1(CD54) and LFA‐3(CD58) in human ovarian cancer
SANTIN A, HERMONAT P, HISERODT J, CHIRIVA‐INTERNATI M, RAVAGGI A, WOODLIFF J, BARCLAY D, PECORELLI S, PARHAM G. Expression and cytokine mediated modulation of adhesion/costimulation molecules ICAM‐1(CD54) and LFA‐3(CD58) in human ovarian cancer. International Journal Of Gynecological Cancer 1997, 7: 273-278. DOI: 10.1046/j.1525-1438.1997.00453.x.Peer-Reviewed Original ResearchTumor cellsICAM-1Fresh tumorsFresh ovarian tumor cellsClonal T-cell proliferationICAM-1/LFAICAM-1 antigenT cell proliferationMolecules ICAM-1Human ovarian cancerHuman ovarian tumorsLFA-3 antigensOvarian tumor cellsSurface antigen expressionAntigen-independent conjugate formationLFA-3 moleculesT cell recognitionNumber of cytokinesCostimulation pathwayTumor vaccinesCostimulatory moleculesOvarian tumorsHelper cytokinesIL-2Cytokines TNF
1996
Effects of cytokines combined with high‐dose gamma irradiation on the expression of major histocompatibility complex molecules and intercellular adhesion molecule‐1 in human ovarian cancers
Santin A, Rose G, Hiserodt J, Fruehauf J, Eck L, Garcia R, Schranz V, Disaia P, Pecorelli S, Granger G. Effects of cytokines combined with high‐dose gamma irradiation on the expression of major histocompatibility complex molecules and intercellular adhesion molecule‐1 in human ovarian cancers. International Journal Of Cancer 1996, 65: 688-694. PMID: 8598323, DOI: 10.1002/(sici)1097-0215(19960301)65:5<688::aid-ijc21>3.0.co;2-2.Peer-Reviewed Original ResearchConceptsMHC class 1TNF-alphaAntigen expressionIFN-gammaFresh tumorsOvarian cell linesTumor cellsIntercellular adhesion molecule-1Cell linesICAM-1 antigen expressionHuman ovarian cancer cell linesOvarian cancer cell linesMajor histocompatibility complex moleculesICAM-1 antigenCytokines TNF-alphaClass 1Adhesion molecule-1Human ovarian cancerHuman ovarian tumorsEffects of cytokinesHuman ovarian cell linesRemoval of cytokinesICAM-1 surfaceHistocompatibility complex moleculesCancer cell linesEffects of Irradiation on the Expression of Surface Antigens in Human Ovarian Cancer
Santin A, Hiserodt J, Fruehauf J, DiSaia P, Pecorelli S, Granger G. Effects of Irradiation on the Expression of Surface Antigens in Human Ovarian Cancer. Gynecologic Oncology 1996, 60: 468-474. PMID: 8774659, DOI: 10.1006/gyno.1996.0075.Peer-Reviewed Original ResearchConceptsMHC class ISurface antigenHER2-neuHigh dosesClass IITumor cellsCell linesClass IICAM-1 antigenHuman ovarian cancerHuman ovarian carcinoma cell linesOvarian carcinoma cell linesCA 125Carcinoma cell linesOvarian cancerICAM-1Radiation therapyIrradiation-induced upregulationImmune recognitionTumor tissueAntigenDosesCellsExposureExpression