2015
Future Directions and New Targets in Endometrial Cancer
Black J, Roque D, Gold L, Santin A. Future Directions and New Targets in Endometrial Cancer. Current Clinical Oncology 2015, 259-271. DOI: 10.1007/7631_2015_1.Peer-Reviewed Original ResearchEndometrial cancerNext-generation sequencingPathway aberrationsMolecular aberrationsUnique molecular characteristicsCancerNew targetsSomatic mutationsTherapyHeterogeneous somatic mutationsMolecular characteristicsCompelling evidenceGeneration sequencingRecent advancesProper classificationAberrationsTumorsDisease
2013
Updates in therapy for uterine serous carcinoma
Roque DM, Santin AD. Updates in therapy for uterine serous carcinoma. Current Opinion In Obstetrics & Gynecology 2013, 25: 29-37. PMID: 23138439, DOI: 10.1097/gco.0b013e32835af98d.Peer-Reviewed Original ResearchConceptsUterine serous carcinomaSerous carcinomaTreatment of USCPaclitaxel-resistant diseasePI3/Akt/mTOR pathwayClass III β-tubulinEarly-stage diseaseNew target antigensAKT/mTOR pathwayVascular endothelial growth factorDistinct molecular pathogenesisHER2/neuIII β-tubulinCurrent clinical approachesEndothelial growth factorNovel microtubule-stabilizing agentEndometrial cancerAggressive variantOptimal therapyProspective studyPathway aberrationsClinical investigationSmall molecule inhibitorsTarget antigenClinical approach