2016
Molecular diagnosis and molecular profiling to detect treatment-resistant ovarian cancer
English DP, Menderes G, Black J, Schwab CL, Santin AD. Molecular diagnosis and molecular profiling to detect treatment-resistant ovarian cancer. Expert Review Of Molecular Diagnostics 2016, 16: 769-782. PMID: 27169329, DOI: 10.1080/14737159.2016.1188692.Peer-Reviewed Original ResearchConceptsChemo-resistant diseaseOvarian cancerMolecular profilingOptimal cytoreductive surgeryRecurrent ovarian cancerEpithelial ovarian cancerLong non-coding RNA expressionLong-term survivalAbsence of improvementCancer stem cellsStem cell markersAdjuvant chemotherapyCytoreductive surgeryNon-coding RNA expressionCancer 5Gynecologic tumorsMEDLINE searchNew agentsMolecular mediatorsTerm survivalCancerCell markersDiseaseRNA expressionChromosomal aberrations
2010
High-grade, chemotherapy-resistant ovarian carcinomas overexpress epithelial cell adhesion molecule (EpCAM) and are highly sensitive to immunotherapy with MT201, a fully human monoclonal anti-EpCAM antibody
Richter CE, Cocco E, Bellone S, Silasi DA, Rüttinger D, Azodi M, Schwartz PE, Rutherford TJ, Pecorelli S, Santin AD. High-grade, chemotherapy-resistant ovarian carcinomas overexpress epithelial cell adhesion molecule (EpCAM) and are highly sensitive to immunotherapy with MT201, a fully human monoclonal anti-EpCAM antibody. American Journal Of Obstetrics And Gynecology 2010, 203: 582.e1-582.e7. PMID: 20870202, PMCID: PMC2993821, DOI: 10.1016/j.ajog.2010.07.041.Peer-Reviewed Original ResearchMeSH KeywordsAntibodies, MonoclonalAntibodies, Monoclonal, HumanizedAntigens, NeoplasmAntineoplastic AgentsBiomarkers, TumorCell Adhesion MoleculesCell Line, TumorDrug Resistance, NeoplasmFemaleFlow CytometryHumansImmunotherapyNeoplasm StagingOvarian NeoplasmsReverse Transcriptase Polymerase Chain ReactionRNA, MessengerSensitivity and SpecificityConceptsAntibody-dependent cell-mediated cytotoxicityComplement-dependent cytotoxicityReal-time polymerase chain reactionEpithelial cell adhesion moleculePolymerase chain reactionOvarian carcinomaInterleukin-2Cell adhesion moleculeFlow cytometryHighest messenger RNA expressionCell linesAdhesion moleculesCell-mediated cytotoxicityOvarian cancer cell linesEffective treatment optionChromium release assaysChain reactionMessenger RNA expressionCancer cell linesOvarian diseaseTreatment optionsOvarian cancerEpCAM expressionAnti-EpCAM antibodyRNA expression