2012
Neoadjuvant chemotherapy (NACT) is an effective way of managing elderly women with advanced stage ovarian cancer (FIGO Stage IIIC and IV)
Glasgow MA, Yu H, Rutherford TJ, Azodi M, Silasi D, Santin AD, Schwartz PE. Neoadjuvant chemotherapy (NACT) is an effective way of managing elderly women with advanced stage ovarian cancer (FIGO Stage IIIC and IV). Journal Of Surgical Oncology 2012, 107: 195-200. PMID: 22648987, DOI: 10.1002/jso.23171.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgedAged, 80 and overAntineoplastic AgentsAntineoplastic Combined Chemotherapy ProtocolsCarboplatinCarcinoma, Ovarian EpithelialChemotherapy, AdjuvantCohort StudiesDrug Administration ScheduleFemaleHumansNeoadjuvant TherapyNeoplasm StagingNeoplasms, Glandular and EpithelialOvarian NeoplasmsPaclitaxelRetrospective StudiesSurvival AnalysisTreatment OutcomeConceptsEpithelial ovarian cancerAdvanced stage ovarian cancerUpfront cytoreductive surgeryNeoadjuvant chemotherapyStage ovarian cancerCytoreductive surgeryOvarian cancerNACT patientsAge 70Stage IV epithelial ovarian cancerAdvanced epithelial ovarian cancerImproved progression-free survivalRetrospective cohort studyShorter ICU stayStage IV diseaseProgression-free survivalLess blood lossSmall bowel resectionOverall survival analysisICU staySame chemotherapyUpfront surgeryMacroscopic diseasePerioperative morbidityStage IIIC
1994
Follow-up after Primary Therapy: Management of the Symptomatic Patient—Surgery
Pecorelli S, Sartori E, Santin A. Follow-up after Primary Therapy: Management of the Symptomatic Patient—Surgery. Gynecologic Oncology 1994, 55: s138-s142. PMID: 7835798, DOI: 10.1006/gyno.1994.1353.Peer-Reviewed Original ResearchConceptsSecondary surgeryStage IIICCisplatin chemotherapyStage INegative second-look surgeryMacroscopic residual tumorNegative second lookSecond-line chemotherapyEvidence of diseaseResidual tumor volumeSecond-look surgeryImportant prognostic parameterBowel obstructionPelvic recurrencePrimary surgeryPrimary therapyMost patientsPalliative roleResidual tumorPatients surgeryPrognostic parametersDefinitive procedureDegree of differentiationVisible tumorTumor volume