2021
A phase 2 evaluation of pembrolizumab for recurrent Lynch‐like versus sporadic endometrial cancers with microsatellite instability
Bellone S, Roque DM, Siegel ER, Buza N, Hui P, Bonazzoli E, Guglielmi A, Zammataro L, Nagarkatti N, Zaidi S, Lee J, Silasi D, Huang GS, Andikyan V, Damast S, Clark M, Azodi M, Schwartz PE, Tymon‐Rosario J, Harold JA, Mauricio D, Zeybek B, Menderes G, Altwerger G, Ratner E, Alexandrov LB, Iwasaki A, Kong Y, Song E, Dong W, Elvin JA, Choi J, Santin AD. A phase 2 evaluation of pembrolizumab for recurrent Lynch‐like versus sporadic endometrial cancers with microsatellite instability. Cancer 2021, 128: 1206-1218. PMID: 34875107, PMCID: PMC9465822, DOI: 10.1002/cncr.34025.Peer-Reviewed Original ResearchConceptsObjective response rateImmune checkpoint inhibitorsProgression-free survivalEndometrial cancerWhole-exome sequencingSporadic endometrial cancerOverall survivalEnd pointPhase 2 pilot studyPrimary end pointSecondary end pointsTumor mutation burdenPhase 2 evaluationLarger confirmatory studiesAntigen processing/presentationProcessing/presentationCheckpoint inhibitorsSurgical resectionICI resistanceDMMR patientsPrognostic significanceDMMR tumorsMechanisms of resistanceLocal treatmentSporadic MSI
2007
Low-grade Fibromyxoid Sarcoma Presenting Clinically as a Primary Ovarian Neoplasm
Winfield HL, De Las Casas LE, Greenfield WW, Santin AD, McKenney JK. Low-grade Fibromyxoid Sarcoma Presenting Clinically as a Primary Ovarian Neoplasm. International Journal Of Gynecological Pathology 2007, 26: 173-176. PMID: 17413985, DOI: 10.1097/01.pgp.0000228145.36807.43.Peer-Reviewed Original ResearchConceptsLow-grade fibromyxoid sarcomaFibromyxoid sarcomaMesenchymal neoplasmsLeft-sided pelvic massDisease 11 monthsLeft ovarian massPrimary ovarian neoplasmsSecondary ovarian involvementMiddle-aged patientsBland spindle cell proliferationLeft hypogastric arteryMalignant mesenchymal neoplasmDeep soft tissuesSpindle cell proliferationRetroperitoneal sarcomaAbdominal painUrinary frequencyHypogastric arteryOvarian involvementSurgical resectionOvarian neoplasmsLeft ureterOvarian massesPelvic massFleshy mass